TYK2 Antibody

Code CSB-PA025391LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA025391LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA025391LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TYK2 Polyclonal antibody
Uniprot No.
Target Names
TYK2
Alternative Names
JTK 1 antibody; JTK1 antibody; Non receptor tyrosine protein kinase 2 antibody; Non receptor tyrosine protein kinase TYK2 antibody; Non-receptor tyrosine-protein kinase TYK2 antibody; OTTHUMP00000232745 antibody; OTTHUMP00000232746 antibody; OTTHUMP00000232748 antibody; Protein Tyrosine Kinase 2 antibody; TYK 2 antibody; Tyk2 antibody; TYK2_HUMAN antibody; Tyrosine kinase 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Non-receptor tyrosine-protein kinase TYK2 protein (286-372AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TYK2 Antibody (Product code: CSB-PA025391LA01HU) is Non-conjugated. For TYK2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA025391LB01HU TYK2 Antibody, HRP conjugated ELISA
FITC CSB-PA025391LC01HU TYK2 Antibody, FITC conjugated
Biotin CSB-PA025391LD01HU TYK2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signaling. Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2. In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
Gene References into Functions
  1. New ELAVL1-TYK2 fusion gene is oncogenic in acute myeloid leukemia. PMID: 27189703
  2. TYK2 gene variants do not seem to play an important role in Chagas disease susceptibility and/or chronic Chagas cardiomyopathy PMID: 29304122
  3. TYK2 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population PMID: 28846454
  4. TYK2 activating mutants and fusion proteins were detected in patients diagnosed with leukaemic diseases suggesting that TYK2 is a potent oncogene. PMID: 26631911
  5. TYK2 genetic variants are differentially associated with common autoimmune diseases PMID: 27807284
  6. High TYK2 expression is associated with B-cell lymphoma. PMID: 28716895
  7. These data indicate that germline activating TYK2 mutations predispose to the development of ALL. PMID: 27733777
  8. TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. PMID: 28704535
  9. TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 pathway in SSc pathophysiology. PMID: 26338038
  10. Clinical genomic analysis of the current series of NF1-MPNST cases found that TYK2 is a new gene mutated in MPNST. PMID: 27875628
  11. Results demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with systemic lupus erythematous (SLE) in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians. [meta-analysis] PMID: 26980740
  12. demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population. PMID: 25744728
  13. The TYK2 promoter variant is associated with an overall risk for diabetes. PMID: 26288847
  14. Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus PMID: 26294277
  15. The majority of disease-associated mutations in JAKs map to a pseudokinase domain (JH2), demonstrating its central regulatory function. PMID: 26359499
  16. the role of TYK2 in the pathogenesis of rheumatoid arthritis PMID: 25849893
  17. present findings suggest that TYK2 regulates apoptotic and proinflammatory pathways in pancreatic beta-cells via modulation of IFNalpha signaling, subsequent increase in MHC class I protein, and modulation of chemokines such as CXCL10. PMID: 26239055
  18. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. PMID: 25762719
  19. Data indicate a chimeric fusion involving nucleophosmin NPM1 (5q35) and TYK2 kinase (19p13) that encodes an NPM1-TYK2 protein in cutaneous CD30 antigen-positve lymphoproliferative disorders. PMID: 25349176
  20. Immune cell dysfunction may contribute to enhancement and maintenance of immune inflammatory and autoimmune responses by production of pathogenic cytokines and immune complexes. The role of Tyk2 in innate and adaptive immune cells is discussed. Review. PMID: 24654603
  21. In cellular assays, SAR-20347 dose dependently (1 nM-10 muM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors. PMID: 25156366
  22. TYK2 as a novel associated locus for idiopathic inflammatory myopathies. PMID: 24812289
  23. Here, we report the 2.8-A structure of the two-domain pseudokinase-kinase module from the JAK family member TYK2 in its autoinhibited form. PMID: 24843152
  24. The crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with peptide motif from the interferon-alpha receptor chain 1 (IFNAR1) is presented. PMID: 24704786
  25. Our results indicate that the biological processes that require TYK2 catalytic function in humans are restricted to the IL-12 and IL-23 pathways. PMID: 23894201
  26. TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility. PMID: 23000200
  27. Two rare autoimmune disease-associated Tyk2 variants are catalytically impaired but signaling competent. PMID: 23359498
  28. The rs6445975 polymorphism of phox homology domain containing serine/threonine kinase and the rs2304256 polymorphism of tyrosine kinase 2 are associated with the development of systemic lupus erythematosus in Europeans PMID: 22592861
  29. The most associated variant in primary biliary cirrhosis was in chromosome 19, a low-frequency nonsynonymous single nucleotide polymorphism in TYK2. PMID: 22961000
  30. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
  31. This study demonistrated that Rs55762744 is a rare variant of modest effect on multiple sclerosis risk affecting a subset of patients. PMID: 22744673
  32. Studied the doubly tagged full-length construct, H6-FL-TYK-2-FLAG. In the presence of ATP and a peptide substrate, H6-FL-TYK-2-FLAG showed a marked lag in phosphopeptide product formation. TYK-2 KD showed no such lag. PMID: 22486643
  33. data highlight the role of TYK2 downregulation in breast cancer cell de-differentitation and initiation of regional metastasis PMID: 22116632
  34. Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2 PMID: 22046141
  35. infection of airway epithelial cells with hMPV decreased cellular level of Janus tyrosine kinase (Jak1) and tyrosine kinase 2 (Tyk2) PMID: 21949722
  36. This meta-analysis demonstrates that autoimmune and inflammatory diseases is associated with TYK2 gene rs34536443 and rs2304256 polymorphisms, but not rs280523, rs280519, rs12720270 and rs12720356. PMID: 21140222
  37. The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. PMID: 21757742
  38. Data suggest that TYK2 polymorphisms were not associated with systemic lupus erythematosus in Hong Kong Chinese, but that rs2304256 and rs12720270 may be associated with photosensitivity and discoid rash. PMID: 21196586
  39. The rs34536443 variant effect on multiple sclerosis susceptibility might be mediated by deviating T lymphocyte differentiation toward a Th2 phenotype. PMID: 21354972
  40. Tyk2 deficiency and clinical manifestations of hyper IgE syndromes (Review) PMID: 21178271
  41. Siva-1 forms a functional complex with Tyk2 and participates in the transduction of signals that inhibit B lymphocyte growth. PMID: 20727854
  42. Here, the authors report the crystal structures of TYK2, a first in class structure, and JAK3 in complex with PAN-JAK inhibitors CP-690550 and CMP-6, both of which bind in the ATP-binding cavities of both JAK isozymes. PMID: 20478313
  43. Single-nucleotide polymorphism in TYK2 gene is confirmed to be associated with multiple sclerosis. PMID: 19888296
  44. rs2304256 associated with increased risk of discoid lupus erythematosus PMID: 19758313
  45. Studies indicate that the highest T1D association was at marker rs2304256 (odds ratio (OR) = 0.86; 95%CI = 0.82-0.90) in the TYK2 gene 19p13.2See TYK2 gene at chromosome 19p13.2. PMID: 19966805
  46. Data show that Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. PMID: 12554654
  47. evidence that the small GTPases RhoA and Rac1, but not Cdc42, are directly associated with Tyk2 and PI3-K in an uPA/uPAR-dependent fashion and are necessary to mediate the uPA/uPAR-directed migration via the Tyk2/PI3-K signalling complex in human VSMC PMID: 12719789
  48. Catalytically active Tyk2 is necessary for Janus kinase 2 phosphorylation and association with the platelet-activating factor receptor. PMID: 14500680
  49. In the IFN signaling pathway leading to STAT activation, both JAK1 and TYK2 are essential, whereas NF-kappaB activation requires only TYK2. PMID: 15883164
  50. mutations in the JAK1 and Tyk2 genes may be identified as initial molecular defects in human cancers and autoimmune diseases PMID: 16239216

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Involvement in disease
Immunodeficiency 35 (IMD35)
Protein Families
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Database Links

HGNC: 12440

OMIM: 176941

KEGG: hsa:7297

STRING: 9606.ENSP00000264818

UniGene: Hs.75516

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