TYK2

TYK2, tyrosine kinase 2, alias JTk1, IMD35.TYK2 is a non-receptor tyrosine kinase, one of the members of the Janus kinase (JAK) family, which is encoded by its own gene in human cells. Its mechanism of action is mainly to participate in the signaling of a variety of cytokines through its kinase activity, especially closely related to the signaling of cytokines such as IL-12, IL-23, and type I interferon, etc. TYK2 activates the downstream JAK-STAT signaling pathway by binding to the receptor of these cytokines, thus regulating the proliferation, differentiation, and effector functions of the immune cells.TYK2 is of biological significance is very broad, and it plays a key role in immune response, cell proliferation, differentiation, and tumorigenesis, etc. Abnormal function of TYK2 has been associated with a variety of diseases, including psoriasis, inflammatory bowel disease, systemic lupus erythematosus, and other autoimmune diseases. As a result, TYK2 has become a popular target for drug development, and in particular, variant inhibitors targeting its regulatory structural domains, such as deucravacitinib, have shown promising efficacy and safety in the treatment of psoriasis. Such variant inhibitors achieve precise inhibition of TYK2 by binding to its unique structural domain, reducing the adverse effects of other JAK family members and providing new ideas and approaches for the treatment of related immune-mediated diseases.