| Code | CSB-PA890933HB01HU |
| Size | US$299 |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Homo sapiens (Human) ZNRF3 Polyclonal antibody |
| Uniprot No. | Q9ULT6 |
| Target Names | ZNRF3 |
| Alternative Names | ZNRF3 antibody; KIAA1133 antibody; RNF203 antibody; E3 ubiquitin-protein ligase ZNRF3 antibody; EC 2.3.2.27 antibody; RING finger protein 203 antibody; RING-type E3 ubiquitin transferase ZNRF3 antibody; Zinc/RING finger protein 3 antibody |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) |
| Immunogen Species | Homo sapiens (Human) |
| Conjugate | HRP |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
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| Gene References into Functions |
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| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Protein Families | ZNRF3 family |
| Database Links |
HGNC: 18126 OMIM: 612062 KEGG: hsa:84133 STRING: 9606.ENSP00000443824 UniGene: Hs.604200 |
