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NRF3 (Zinc and Ring Finger 3) belongs to the RING (Really Interesting New Gene) finger protein family, characterized by its possession of a RING domain, a specific type of domain known for its E3 ubiquitin ligase activity. One of the primary functions of ZNRF3 is to regulate the stability of receptors and proteins on the cell membrane. It accomplishes this by attaching ubiquitin molecules to target proteins, marking them for degradation. This process, known as ubiquitination, is a crucial mechanism that cells use to control protein levels and signaling pathways. In the field of cancer research, ZNRF3 is associated with the regulation of the Wnt signaling pathway, which plays a pivotal role in various cancers.
Recombinant Human E3 ubiquitin-protein ligase ZNRF3(ZNRF3),partial (Active) CSB-MP890933HU
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZNRF3 at 5 μg/ml can bind Human RSPO2 (CSB-MP751021HU1(M)), the EC50 is 5.091-6.991 ng/mL.
The following ZNRF3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ZNRF3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA890933HA01HU | ZNRF3 Antibody |
Human | ELISA, IF |
| CSB-PA890933HB01HU | ZNRF3 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA890933HC01HU | ZNRF3 Antibody, FITC conjugated |
Human | |
| CSB-PA890933HD01HU | ZNRF3 Antibody, Biotin conjugated |
Human | ELISA |
ZNRF3 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA950935XA01DIL | znrf3 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
ZNRF3 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP716332MO CSB-EP716332MO CSB-BP716332MO CSB-MP716332MO CSB-EP716332MO-B |
Recombinant Mouse Zinc/RING finger protein 3 (Znrf3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ZNRF3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP890933HU-B |
Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial |
In Vivo Biotinylation in E.coli |
| CSB-EP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial |
E.coli |
| CSB-EP890933HUe1 | Recombinant Human Zinc/RING finger protein 3 (ZNRF3),Partial |
E.coli |
| CSB-BP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial |
Baculovirus |
| CSB-YP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial |
Yeast |
| CSB-MP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial (Active) |
Mammalian cell |
