Recombinant Chicken G1/S-specific cyclin-D1 (CCND1)

Code CSB-YP004811CH
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Source Yeast
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Code CSB-EP004811CH
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Source E.coli
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Code CSB-EP004811CH-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004811CH
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Source Baculovirus
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Code CSB-MP004811CH
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CCND1
Uniprot No.
Alternative Names
CCND1G1/S-specific cyclin-D1
Species
Gallus gallus (Chicken)
Expression Region
1-292
Target Protein Sequence
MEHQLQCCEV ETIRRAYLDA NLLNDRVLQT MLKAEETCSP SVSYFKCVQK EILPYMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS FEPLKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLTKMPL AEDTKQIIRK HAQTFVALCA TDVKFISNPP SMIAAGSVVA AVQGLHLGNT NTFLSYQCLT HFLSQVIKCD PDCLRACQEQ IESLLESSLR QAQQHNVSSE TKTVEDEADL SCTPTDVRDV NI
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Gene References into Functions
  1. motoneuron progenitors in the embryonic spinal cord persistently express Cyclin D1 during the initial phase of differentiation, while down-regulating Cyclin D2 PMID: 21709239
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Cyclin family, Cyclin D subfamily
Database Links
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