Recombinant Human Adenylate cyclase type 9(ADCY9) ,partial

Code CSB-YP001345HU
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Source Yeast
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Code CSB-EP001345HU
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Source E.coli
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Code CSB-EP001345HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001345HU
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Source Baculovirus
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Code CSB-MP001345HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ADCY9
Uniprot No. O60503
Alternative Names ADCY 9; ADCY9; ADCY9_HUMAN; Adenylate cyclase 9; Adenylate cyclase type 9; Adenylate cyclase type IX; Adenylyl cyclase 9; ATP pyrophosphate lyase 9; ATP pyrophosphate-lyase 9; KIAA0520; Type IX adenylyl cyclase; Type IX ATP pyrophosphate lyase
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors
Gene References into Functions
  1. ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS and mRNA expression of ADCY9 were correlated to colon cancer TNM staging. PMID: 29292367
  2. polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers PMID: 28076799
  3. The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene. PMID: 25583994
  4. The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported. PMID: 24722286
  5. Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b. PMID: 24269684
  6. in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. PMID: 22778270
  7. The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells. PMID: 11299302
  8. A case-control study using Ile772Met and a repeat (TTTA)n showed no significant association with mood disorders in Japan. PMID: 11840511
  9. associated with bipolar disorder using pedigree linkage disequilibrium PMID: 12082561
  10. blocking glycosylation of AC9 significantly attenuates Galpha(s) stimulation. PMID: 14996950

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).
Database Links

HGNC: 240

OMIM: 603302

KEGG: hsa:115

STRING: 9606.ENSP00000294016

UniGene: Hs.391860

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