ADCY9 Antibody

Code CSB-PA178331
Size US$297
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  • Western blot analysis of extracts from HuvEc cells, using ADCY9 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using ADCY9 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADCY9 Polyclonal antibody
Uniprot No.
Target Names
ADCY9
Alternative Names
ADCY 9 antibody; ADCY9 antibody; ADCY9_HUMAN antibody; Adenylate cyclase 9 antibody; Adenylate cyclase type 9 antibody; Adenylate cyclase type IX antibody; Adenylyl cyclase 9 antibody; ATP pyrophosphate lyase 9 antibody; ATP pyrophosphate-lyase 9 antibody; KIAA0520 antibody; Type IX adenylyl cyclase antibody; Type IX ATP pyrophosphate lyase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from N-terminal of Human ADCY9.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors.
Gene References into Functions
  1. ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS and mRNA expression of ADCY9 were correlated to colon cancer TNM staging. PMID: 29292367
  2. polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers PMID: 28076799
  3. The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene. PMID: 25583994
  4. The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported. PMID: 24722286
  5. Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b. PMID: 24269684
  6. in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. PMID: 22778270
  7. The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells. PMID: 11299302
  8. A case-control study using Ile772Met and a repeat (TTTA)n showed no significant association with mood disorders in Japan. PMID: 11840511
  9. associated with bipolar disorder using pedigree linkage disequilibrium PMID: 12082561
  10. blocking glycosylation of AC9 significantly attenuates Galpha(s) stimulation. PMID: 14996950

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity
Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta. Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.
Database Links

HGNC: 240

OMIM: 603302

KEGG: hsa:115

STRING: 9606.ENSP00000294016

UniGene: Hs.391860

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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