ADCY9 Antibody

Code CSB-PA178331
Size US$297
Image
  • Western blot analysis of extracts from HuvEc cells, using ADCY9 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using ADCY9 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADCY9 Polyclonal antibody
Uniprot No. O60503
Target Names ADCY9
Alternative Names ADCY 9 antibody; ADCY9 antibody; ADCY9_HUMAN antibody; Adenylate cyclase 9 antibody; Adenylate cyclase type 9 antibody; Adenylate cyclase type IX antibody; Adenylyl cyclase 9 antibody; ATP pyrophosphate lyase 9 antibody; ATP pyrophosphate-lyase 9 antibody; KIAA0520 antibody; Type IX adenylyl cyclase antibody; Type IX ATP pyrophosphate lyase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from N-terminal of Human ADCY9.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors
Gene References into Functions
  1. ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS and mRNA expression of ADCY9 were correlated to colon cancer TNM staging. PMID: 29292367
  2. polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers PMID: 28076799
  3. The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene. PMID: 25583994
  4. The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported. PMID: 24722286
  5. Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b. PMID: 24269684
  6. in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. PMID: 22778270
  7. The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells. PMID: 11299302
  8. A case-control study using Ile772Met and a repeat (TTTA)n showed no significant association with mood disorders in Japan. PMID: 11840511
  9. associated with bipolar disorder using pedigree linkage disequilibrium PMID: 12082561
  10. blocking glycosylation of AC9 significantly attenuates Galpha(s) stimulation. PMID: 14996950

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).
Database Links

HGNC: 240

OMIM: 603302

KEGG: hsa:115

STRING: 9606.ENSP00000294016

UniGene: Hs.391860

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