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The recombinant Human FGF2 is a yeast-expressed (143-288aa) protein with N-terminal 6xHis tag. The purity is 90%+ measured by SDS-PAGE. The highly developed genetic system, ease of use, reduced time input, and costs have made Pichia Pastoris an attractive organism for the expression and production of recombinant proteins. So we choose the Yeast system to express this recombinant FGF2 protein, which is able to carry specifically designed plasmids, and the plasmid used consists of restriction sites that can be used to insert the gene sequence of interest. Transformation of yeasts with the plasmid produces the desired protein and can be appropriately scaled up.FGF2, a potent mitogen for fibroblasts, exerts multiple functions in tissue development and repair via interactions with FGFR1-3. The involvement of FGF2 in cell proliferation, differentiation, migration, and apoptosis in airway structural cells contributes to epithelial repair, ASMCs hyperplasia, and vascular remodeling. Since FGF2 plays important role in angiogenesis, extracellular matrix regulation, cell differentiation, and inflammatory responses, it is thus related to the development, progression, and pathogenesis of tumors. Studies have shown that FGF2 mediates cell migration and invasion in breast cancer, pancreatic cancer, astrocytes, and gliomas.
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