Recombinant Human Interleukin-18 (IL18)

Code CSB-EP614514HU(A4)
Size US$2228
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names IL18
Uniprot No. Q14116
Research Area Immunology
Alternative Names Iboctadekin; IFN gamma inducing factor; IFN-gamma-inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL-1 gamma; IL-18; IL1 gamma; IL18; IL18 protein; IL18_HUMAN; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interferon gamma-inducing factor; Interleukin 1 gamma; Interleukin 18 (interferon-gamma-inducing factor); Interleukin 18; Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-193aa
Target Protein Sequence MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 22.3kDa
Protein Length Full Length
Tag Info Tag-Free
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Gene References into Functions
  1. The results of the linkage disequilibrium test showed that the -137G/C and -607G/T sites had no linkage disequilibrium in the present study. PMID: 29926984
  2. SNPs associated with genetically determined high activity of TLR5 among patients with CD and genetically determined high IL-12 and IL-18 levels among patients with UC. PMID: 28139755
  3. The adipose tissue IL-18R/IL-18 expression is enhanced in obesity which associates with proinflammatory gene signature and insulin resistance in these individuals. PMID: 28508444
  4. Our study implied that elevated IL-18 expression and downregulation of GAS5 in serums might contribute to insulin resistance in polycystic ovary syndrome patients. PMID: 29648472
  5. Studied serum level of interleukin 18 (IL18) in HIV and Hepatitis C (HCV) coinfection and monoinfection. Found shown that IL-18 is increased in HIV/HCV coinfection when compared with monoinfection and that this increase is likely due to additive sensing of both viruses. PMID: 27927859
  6. not associated with obesity in this study PMID: 28634744
  7. multiple myeloma patients with IL-18 (rs16944) TT had the highest hemoglobin concentration PMID: 30211233
  8. These results suggest that increased IL-18 secretion from larger numbers of neutrophils elicits mechanical hyperalgesia. PMID: 29353540
  9. The results of this study suggests that IL-18 rs187238 and rs1946518 SNPs may be the cause of the AA susceptibility. PMID: 29349811
  10. Studied association of single nucleotide polymorphisms of interleukin-18 (IL 18) and lower extremity deep venous thrombosis in a Chinese population. PMID: 29105174
  11. PI3K is a signal linker between L-selectin and PSGL-1 in IL-18 transcriptional activation at the promoter level. PMID: 29218606
  12. IL-18 is a susceptibility gene for the disease in southern Chinese children. PMID: 30059753
  13. Postoperative serum Cystatin C, IL-18 and Uric acid after 24h were significantly associated with acute kidney injury PMID: 29627485
  14. IL-18 is elevated in polycystic ovary syndrome patients, even in lean ones, and is correlated with insulin resistance and atherosclerotic cardiovascular risk PMID: 29105530
  15. HuR plays an important role in the progression of esophageal carcinoma by targeting IL-18. PMID: 28231690
  16. The IL18 promoter SNP, rs1946518, is a potential risk factor of periodontitis among young Japanese women. PMID: 29129846
  17. The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of gestational diabetes mellitus as well as with BMI in pregnant women. PMID: 28580570
  18. This is the first study to demonstrate that higher pre-treatment IL-18 is associated with HBeAg seroconversion in patients with HIV/HBV co-infection after 48 weeks of HBV cART, which suggests a role for the inflammasome in a favorable response to treatment. PMID: 28195558
  19. Polymorphisms in the IL-18 gene are associated with viral load in Hepatitis B virus . PMID: 30045250
  20. higher level of IL-18 was observed in the monocyte supernatant of the extremely preterm group during late-onset sepsis PMID: 29042061
  21. Increased production of IL-18 in the gut-associated lymphoid tissue and peripheral blood of HIV infected patients. PMID: 29672590
  22. this review discusses IL-18 biological properties and role in disease pathogenesis PMID: 29247988
  23. IL-18 mRNA expression was increased significantly in chronic myeloid leukemia patients PMID: 29097263
  24. these results suggest that the HIV-induced IL-18 plays a role in increased intestinal permeability and microbial translocation observed in HIV-infected individuals. PMID: 29601578
  25. IL-18 gene variants may serve as important biomarkers in predicting the occurrence of nasopharyngeal carcinoma in Asian population. PMID: 29185028
  26. The association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). PMID: 28000712
  27. These findings indicate that the IL-18 rs1946518 SNP in the donor liver is a risk factor for developing bacterial infection after liver transplantation. PMID: 29061223
  28. Serum levels of IL-18 in nephropathic patient significantly rise and Serum levels of IL-18 might be a predictor factor of progression of diabetic nephropathy. PMID: 27663212
  29. A higher IL-18 immunostaining in stroma of IBC and LABC was observed in comparison with tumor cells, but stromal immunoexpression was similar between IBC and LABC. PMID: 28766916
  30. IL-18 was increased in lung myeloid cells in severe chronic obstructive pulmonary disease. PMID: 28830544
  31. a large proportion blood basophils from patients with asthma express IL-18 and IL-18BP. mast cells and basophils are implicated in the pathogenesis of asthma via an IL-18-related mechanism. PMID: 29505668
  32. On PICU day 1, interleukin-18 predicted acute kidney injury with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin and liver fatty acid binding protein predicted acute kidney injury with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher. Interleukin-18 and liver fatty acid binding protein on day 1 predicted prolonged acute kidney injury. PMID: 28430754
  33. Data show that tumor-derived IL-18 induced PD-1 expression on NK cells and is associated with poor prognosis in triple-negative breast cancer. PMID: 28415798
  34. IL-23, alone and in combination with IL-18 and sRAGE, identified bacterial meningitis with excellent accuracy. Following validation, these markers could aid clinicians in diagnosis of bacterial meningitis and decision-making regarding prolongation of antibiotic therapy PMID: 29394248
  35. cardiac IL-18 and circulating IL-18 are involved in the pathogenesis of Fabry cardiomyopathy and left ventricular hypertrophy. PMID: 27888626
  36. Erdr1 is negatively expressed relative to Il-18 in psoriatic lesional skin. PMID: 26990875
  37. rs187238 was not associated with T1D in the Euro-Brazilian population. PMID: 28973736
  38. IL-18 (mRNA) in skeletal muscle appears to be involved in the regulation of intramuscular lipid metabolism and hypertriglyceridemia PMID: 29342149
  39. The evidence for influenza A virus activation via an indirect, IL-18-dependent mechanism indicates that MAIT cells are protective in influenza, and also possibly in any human disease process in which inflammation and IL-18 production occur. PMID: 27543331
  40. The development of urticaria, asthma, dermatitis, rhinitis, and eosinophilic disorders all have demonstrated correlations to increased IL-18 levels either in the tissue or systemically. IL-18 represents a novel site of immune regulation in not only allergic conditions, but also autoimmune diseases and other instances of aberrant immune functioning. PMID: 27496752
  41. Results suggest that a common functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibility to stress-related depression and anxiety through effects on threat-related amygdala function, a risk pathway specific to women. PMID: 27430614
  42. human platelets contain transcripts for the IL-18 gene. They synthesize the cytokine de novo, process and release it upon activation. PMID: 27914933
  43. abnormal IL-18 expression is induced by genital infection and induces damage to male reproductive capacity, thereby causing male infertility PMID: 26856767
  44. IL-18 level was found to be significantly elevated in CAD patients compared with control individuals PMID: 28059484
  45. The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 and IL-18BP, were elevated in the patients with primary Sjogren's syndrome. PMID: 28057714
  46. an imbalance in the production of IL-18 and its antagonist (an increase in the production of IL-18 with a decrease, no increase or an insufficient increase in the production of IL-18BP) has been described in many chronic inflammatory diseases in humans. PMID: 26898120
  47. among systemic sclerosis patients in China, dyspnea was significantly associated with IL-18 -607C/A genotype frequency PMID: 27098064
  48. We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index. PMID: 27313119
  49. Serum IL-18 levels are significantly elevated in depressive patients. PMID: 27455146
  50. IL-18 cooperates with IL-15 to promote group 3 innate lymphoid cell (ILC3) proliferation and IL-22 production; describe an IL-18-induced, NF-kappaB-mediated mechanism that regulates IL-22 in ILC3s; at steady-state, IL-18 produced by dendritic cells mediates IL-22 production by ILC3s to help maintain normal tissue integrity PMID: 28842466
  51. IL-18 alleles, -656T (rs1946519) and -607A (rs1946518), are associated with dust mite-sensitive allergic rhinitis in Thai population. PMID: 28692122
  52. IL-18 SNPs were associated with pulmonary tuberculosis with co-morbid diabetes in patients and their household contacts. PMID: 28652186
  53. this study shows il-18 restores the phosphoantigen response of Vgamma9Vdelta2+ T cells from HIV-positive individuals on antiretroviral therapy PMID: 28342224
  54. IL-18, IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma. PMID: 28395725
  55. Patients with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic IL18. PMID: 27965258
  56. Genetic polymorphisms within the FUCA2 and IL18 gene regions are also associated with diastolic function in SCD, likely by affecting expression levels of the genes PMID: 27636371
  57. rs187238, rs360719, and rs549908 in IL-18 are associated with reduced risk of atrial fibrillation in Chinese patients. PMID: 28526653
  58. The IL-18-607A/C polymorphism may not contribute directly to the susceptibility to schizophrenia. This polymorphism is associated with clinical psychopathology of schizophrenia patients. Interaction of increased serum level of IL-18 and the IL-18-607A/C polymorphism affects the clinical psychopathological symptoms PMID: 26974498
  59. Genetic variation in IL-18 is associated with IL-18 production in response to HIV and HCV infection, and may explain variability in the inflammatory outcomes of chronic viral infections. PMID: 28300059
  60. IL18-607C>A and IL18-137G>C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression. PMID: 27001087
  61. Patients with subclinical synovitis in rheumatoid arthritis had undetectable/very low levels of Il-18. PMID: 25123522
  62. High serum IL18 expression is associated with Insulin Resistance. PMID: 27362289
  63. The author recently reported that gamma radiation highly increased IL-1beta, IL-18 and IL-33 expression in mouse thymus, spleen and/or bone marrow cells; also circulating IL-18 can be used as a radiation biomarker to track radiation injury in mice, minipigs, and nonhuman primates. This mini-review focuses on the role of IL-18 in response to gamma radiation-induced injury. [review] PMID: 27356067
  64. These results suggested that 25-HC promoted ADC cell migration and invasion in an LXR-dependent manner in the monoculture system but that in the coculture system, the 25-HC-induced IL-1beta secretion enhanced the effect of 25-HC in an LXR-independent manner. PMID: 28167281
  65. Low IL18 expression is associated with malignant melanoma. PMID: 27810076
  66. Suggest that the IL18 gene may have a significant relationship with triglyceride and LDL cholesterol levels in peripheral arterial disease patients. PMID: 26438531
  67. Study demonstrates that the expression of the NLRP3-caspase-1-IL-18 axis is highly expressed in the peripheral blood mononuclear cells of patients with bullous pemphigoid (BP), and correlated with disease activity, suggesting its involvement in the pathogenesis and progression of BP. PMID: 27174093
  68. Serum IL-18 levels were significantly higher in patients with IL-18-137 GG and IL-18-607 CC genotypes before renal transplantation. The influence of these polymorphisms on oxidative stress has not been observed. PMID: 26983036
  69. Furthermore, the correlation between the IL-18 -137G/C polymorphism and HCC-related HBV infection is a risk factor for vascular invasion and has a synergistic effect that can further enhance HCC prognosis. PMID: 27429592
  70. IL-18 is associated with inflammatory activity in gout, as well as with IL-6 levels. PMID: 27219123
  71. Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001 PMID: 27121382
  72. IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients. PMID: 28246425
  73. L-18 -607C/A gene promoter polymorphism is a major genetic factor for determining individual susceptibility to MS. PMID: 27177146
  74. Study showed that adipokine leptin triggered macrophage- related cytokine IL-18 production, possibly contributing to tumor progression in breast cancer cells. PMID: 27082857
  75. Results provide evidence for IL18-607C/A variation related to the pathogenesis of non-small cell lung cancer in the Chinese population studied. PMID: 28002583
  76. findings resolve a long-standing contradiction regarding a tumor-suppressive role for IL18 in established hepatocellular carcinoma and provide a mechanistic explanation for the complex relationship between its expression pattern and hepatocellular carcinoma prognosis PMID: 26893476
  77. IL-18 -372C/G did not contribute to the risk of glioma development in the co-dominant, dominant, and recessive models. Therefore, the IL-18 -607C/A polymorphism was significantly correlated with the risk of Coronary artery disease development. PMID: 27813570
  78. The IL-18 -607C/A and -137G/C polymorphisms do not influence susceptibility to acute pancreatitis in the Chinese patient cohort. PMID: 27706625
  79. both ETA and ETB receptor expression in the renal cortex were significantly attenuated by ovariectomy, and this reduction was not evident in OVX+E2 rats. SIGNIFICANCE: These data suggest that ovarian hormones regulate ET receptor expression and may contribute to sex differences in cardiovascular and renal health. PMID: 27693669
  80. The expression levels of the TNF-alpha, IL-18 and cTnI and the expression levels of the miR-1 and miR-146b could be used to predict viral myocarditis among children. PMID: 27997912
  81. Significant associations were detected between the IL-18 rs187238(G/C) polymorphism and chronic leukemia. The CC genotype may be associated with the risk of CLL. There were no significant associations between the IL-18 rs61667799(G/T), rs5744227(C/G), or rs5744228(A/G) polymorphisms and CLL or CML. PMID: 26376814
  82. Older T2DM patients carrying the C allele of IL-18 G(-137)C polymorphism have a significantly increased risk of CVD. PMID: 27741477
  83. Data suggest that nonlinear resistance training or aerobic interval training for 12 weeks produces no significant changes in serum levels of omentin-1 and interleukin-18 in obese men; however, during a 4-week detraining period, omentin-1 decreases significantly and IL-18 increases significantly. PMID: 27636349
  84. This study aims at investigating whether TNFA -308 G/A and IL18 -137 G/C and -607 C/A polymorphisms are associated with susceptibility to HPV infection/progression to high-grade squamous intraepithelial lesion. PMID: 26079218
  85. The results of this study suggested no significant association between the -607 C/A polymorphism and AD susceptibility when stratified by ethnicity. PMID: 26897018
  86. Kaplan-Meier analysis evidenced a weak effect of IL-18-137G/C genotypes on graft survival after kidney transplantation. PMID: 27109946
  87. The IL-18 -137 G/C polymorphism was significantly associated with an increased risk of recurrent pregnancy loss under a recessive genetic model. For the -607C/A mutation, no association was found under any genetic models. PMID: 26346467
  88. IL-18 is associated with insulin resistance and other cardiovascular risk factors; the CC genotype of the rs1834481 SNP of the IL-18 gene was significantly associated with lower levels of IL-18; the GG genotype of the rs7559479 SNP was associated with significant higher levels of IL-18 PMID: 26205090
  89. Meta-analysis showed that the -607A/C, -920C/T, and -105A/C polymorphisms in IL-18 were significantly associated with increased rheumatoid arthritis risk. However, the -137C/G polymorphism was not associated with rheumatoid arthritis risk under any genetic model. PMID: 26909913
  90. review summarizes the biology of the IL-18/IL-18BP/IL-18R system and its role in the host defense against infections PMID: 26885772
  91. IL-18 seems to be important indicator and predictor of cardiovascular death in two-year follow-up among non-diabetic patients suffering from CKD, with history of AMI in the previous year. PMID: 26669254
  92. IL-18 is an important predictor of mortality in humans with both severe sepsis and septic shock, independent of IL-1beta PMID: 26683353
  93. we report on the first-time detection of in-situ expression of activated IL-18 in the human brain in sALS patients. PMID: 26804591
  94. This study demonstrated that IL-18 is dysregulated in autism spectrum disorders patients. PMID: 26728085
  95. increased susceptibility to thyroid cancer in subjects with TT genotype at position -656 G/T of the promoter PMID: 26041375
  96. Evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. [review] PMID: 26690141
  97. the -607 C/A polymorphism in the IL-18 gene may be associated with susceptibility to esophageal cancer. PMID: 26681034
  98. IL-18 and IL-18R polymorphisms may contribute to the development and lymph node metastasis of PTC. PMID: 26600055
  99. IL-18 -137G/C polymorphism contributed to TB susceptibility in Chinese Han population. PMID: 26474654
  100. levels of IL-18, but not those of IL-18BP or sIL-18R1 are higher in primary Sjogren's syndrome patients than those in controls. PMID: 25736367

Show More

Hide All

Subcellular Location Secreted
Protein Families IL-1 family
Database Links

HGNC: 5986

OMIM: 600953

KEGG: hsa:3606

STRING: 9606.ENSP00000280357

UniGene: Hs.83077

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2020 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1