IL18, or interleukin 18, is a cytokine encoded by the IL18 gene in the human body and is a member of the IL-1 family.IL18 is expressed in a variety of cell types, including T cells, NK cells, and dendritic cells. Its mechanism of action involves binding to the IL18 receptor, which consists of an α-chain and a β-chain, where the α-chain is responsible for ligand binding and the β-chain mediates signaling.IL18 activates downstream signaling pathways through binding to its receptor, such as through the JAK/STAT pathway, which in turn affects cell proliferation, differentiation, and effector functions.
The biological significance of IL18 is mainly reflected in its role as an immunomodulatory factor involved in inflammation and immune response process. It induces T cells to produce interferon-γ (IFN-γ), promotes the activation of NK cells and other immune cells, as well as stimulates the production of cytokines such as tumor necrosis factor-α (TNF-α), IL-1β, etc. IL18 plays an important role in promoting the Th1-type immune response and is closely related to the development of a variety of inflammatory diseases, tumors, and autoimmune diseases. For example, IL18 expression levels are elevated in certain autoimmune diseases and may serve as a marker of disease activity. In addition, the maturation process of IL18 involves a non-classical inflammatory vesicle pathway, in which activation of caspase-4/5 cleaves the precursor IL18, releasing its mature form for biological function.
Recombinant Human Interleukin-18 (IL18) (CSB-EP614514HUd7)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL18 Antibody (CSB-PA614514YA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA614514YA01HU at dilution of 1:20
Human Interleukin 18,IL-18 ELISA KIT (CSB-E07450h)
Validated Data
Code: CSB-E07450h
Size: 48T/ 96T
Sensitivity: 7.8 pg/mL
Detection Range: 31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following IL18 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL18 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011608GA01HU | IL18 Antibody | Human, Rat | ELISA,WB,IHC,IF |
CSB-PA614514YA01HU | IL18 Antibody | Human | ELISA, IHC |
CSB-PA614514YD01HU | IL18 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA614514YC01HU | IL18 Antibody, FITC conjugated | Human | |
CSB-PA614514YB01HU | IL18 Antibody, HRP conjugated | Human | ELISA |
CSB-PA08377A0Rb | IL18 Antibody | Human | ELISA |
CSB-PA08377B0Rb | IL18 Antibody, HRP conjugated | Human | ELISA |
CSB-PA08377C0Rb | IL18 Antibody, FITC conjugated | Human | |
CSB-PA08377D0Rb | IL18 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA081015 | IL18 Antibody | Human | ELISA,WB,IHC |
CSB-PA634259 | IL18 Antibody | Human | ELISA,WB,IHC |
CSB-RA614514MA1HU | IL18 Recombinant Monoclonal Antibody | Human | ELISA, FC |
IL18 Antibodies for Dog
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA895937LA01DO | IL18 Antibody | Dog | ELISA |
IL18 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011608XA01RA | Il18 Antibody | Rattus norvegicus (Rat) | ELISA, WB (ensure identification of antigen) |
CSB-PA176194ZA01RA | Il18 Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
IL18 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011608ZA01MO | Il18 Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
IL18 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP011608RA CSB-EP011608RA CSB-BP011608RA CSB-MP011608RA CSB-EP011608RA-B |
Recombinant Rat Interleukin-18 (Il18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP176194r | Recombinant Rat Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP011608PI CSB-EP011608PI CSB-BP011608PI CSB-MP011608PI CSB-EP011608PI-B |
Recombinant Pig Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Capra hircus (Goat)
Code | Product Name | Source |
---|---|---|
CSB-YP672507GO CSB-EP672507GO CSB-BP672507GO CSB-MP672507GO CSB-EP672507GO-B |
Recombinant Goat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Boselaphus tragocamelus (Nilgai)
Code | Product Name | Source |
---|---|---|
CSB-YP689269BUN CSB-EP689269BUN CSB-BP689269BUN CSB-MP689269BUN CSB-EP689269BUN-B |
Recombinant Boselaphus tragocamelus Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP819130CH CSB-EP819130CH CSB-BP819130CH CSB-MP819130CH CSB-EP819130CH-B |
Recombinant Chicken Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP850184CA CSB-EP850184CA CSB-BP850184CA CSB-MP850184CA CSB-EP850184CA-B |
Recombinant Cat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP866143BO CSB-EP866143BO CSB-BP866143BO CSB-MP866143BO CSB-EP866143BO-B |
Recombinant Bovine Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP895012HO CSB-EP895012HO CSB-BP895012HO CSB-MP895012HO CSB-EP895012HO-B |
Recombinant Horse Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP895937DO CSB-BP895937DO CSB-MP895937DO CSB-EP895937DO-B |
Recombinant Dog Interleukin-18 (IL18) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP895937DO | Recombinant Dog Interleukin-18 (IL18) | E.coli |
IL18 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP614514HU | Recombinant Human Interleukin-18 (IL18) | Yeast |
CSB-EP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | E.coli |
CSB-YP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | Yeast |
CSB-AP004651HU | Recombinant Human Interleukin-18 (IL18) (Active) | Mammalian cell |
CSB-EP614514HUd7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
CSB-EP614514HUc7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
CSB-EP614514HU CSB-EP614514HU-B |
Recombinant Human Interleukin-18 (IL18) | E.coli In Vivo Biotinylation in E.coli |
CSB-MP614514HU-WD | Recombinant Human Interleukin-18 (IL18) (Active) | Mammalian cell |
IL18 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP011608MO | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
CSB-YP011608MOb0 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
CSB-YP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
CSB-EP011608MO | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
CSB-EP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
IL18 ELISA Kit for Bos taurus (Bovine)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011608BO | Bovine Interleukin-18(IL18) ELISA kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Gallus gallus (Chicken)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10070Ch | Chicken Interleukin 18,IL-18 ELISA KIT | serum, plasma, tissue Homogenates | 1.95 pg/mL |
IL18 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09848c | Dog Interleukin 18,IL-18 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 3.12 pg/mL |
IL18 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04609m | Mouse Interleukin 18,IL-18 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.39 pg/mL |
IL18 ELISA Kit for Sus scrofa (Pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E06781p | Pig Interleukin 18,IL-18 ELISA Kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04610r | Rat Interleukin 18,IL-18 Elisa Kit | serum, plasma, cell culture supernates | 0.039 ng/mL |
IL18 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07450h | Human Interleukin 18,IL-18 ELISA KIT | serum, plasma, urine, tissue homogenates | 7.8 pg/mL |