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| Product Type | Recombinant Protein |
| Uniprot No. | Q96P20 |
| Abbreviation | NLRP3 |
| Species | Homo sapiens (Human) |
| Gene Names | NLRP3 |
| Protein Names | Recommended name: NACHT, LRR and PYD domains-containing protein 3 Alternative name(s): Angiotensin/vasopressin receptor AII/AVP-like Caterpiller protein 1.1 Short name= CLR1.1 Cold autoinflammatory syndrome 1 protein Cryopyrin |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 UTR splice patterns are biologically valid. |
| HGNC | 16400 |
| RGD | 1308314 |
| MGI | 2653833 |
| Function | As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion |
| Involvement in disease | Familial cold autoinflammatory syndrome 1 (FCAS1); Muckle-Wells syndrome (MWS); Chronic infantile neurologic cutaneous and articular syndrome (CINCA) |
| Subcellular Location | Cytoplasm, cytosol, Inflammasome, Endoplasmic reticulum, Secreted, Nucleus |
| Protein Families | NLRP family |
| Tissue Specificity | Predominantly expressed in macrophages. Also expressed in dendritic cells, B- and T-cells (at protein level) (PubMed:11786556) (PubMed:17164409). Expressed in LPS-treated granulocytes, but not in resting cells (at protein level) (PubMed:17164409). Express |
| Database Links |
HGNC: 16400 OMIM: 120100 KEGG: hsa:114548 STRING: 9606.ENSP00000337383 UniGene: Hs.159483 |
| Pathway |
Lipids and Inflammation
in Atherogenesis
Necroptosis Inflammasome Signaling NOD-like receptor signaling pathway |
| Product Name | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3) ,partial,Yeast |
| Code | CSB-YP822275HU |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3) ,partial,E.coli |
| Code | CSB-EP822275HU |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3) ,partial,Baculovirus |
| Code | CSB-BP822275HU |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3) ,partial,Mammalian cell |
| Code | CSB-MP822275HU |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
NLRP3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005618 | NLRP3 Antibody | Human | WB,ELISA |
| CSB-PA084492 | NLRP3 Antibody | Human | ELISA,IHC |
| CSB-PA993403 | NLRP3 Antibody | Human | ELISA,WB |
NLRP3 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA209407 | NLRP3 Antibody | Human,Mouse,Rat | ELISA,IHC |
NLRP3 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA015871LA01HU | NLRP3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA015871LB01HU | NLRP3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA015871LC01HU | NLRP3 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA015871LD01HU | NLRP3 Antibody, Biotin conjugated | Human | ELISA |
NLRP3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP822275HU(A4M) | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3) | E.coli |
| CSB-EP822275HU1 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3(NLRP3),partial | E.coli |
NLRP3 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E15885h | Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3/C1orf7/CIAS1/NALP3/PYPAF1) ELISA kit | serum, cell culture supernates, cerebrospinal fluid (CSF) | 0.039 ng/mL |
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Species: Homo sapiens (Human)
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Species: Homo sapiens (Human)
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Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Serum amyloid P-component(APCS)
Express system: E.coli
Species: Homo sapiens (Human)
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