Code | CSB-YP822275HU |
Size | Pls inquire other sizes |
Source | Yeast |
Code | CSB-EP822275HU |
Size | Pls inquire other sizes |
Source | E.coli |
Code | CSB-EP822275HU-B |
Size | Pls inquire other sizes |
Source | E.coli |
Conjugate | Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. |
Code | CSB-BP822275HU |
Size | Pls inquire other sizes |
Source | Baculovirus |
Code | CSB-MP822275HU |
Size | Pls inquire other sizes |
Source | Mammalian cell |
Purity | >85% (SDS-PAGE) |
Target Names | NLRP3 |
Uniprot No. | Q96P20 |
Species | Homo sapiens (Human) |
Protein Length | Partial |
Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Form | Lyophilized powder |
Buffer before Lyophilization | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Troubleshooting and FAQs |
Protein FAQs |
Storage Condition | Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Shelf Life | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
Lead Time | Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet | Please contact us to get it. |
Still Have Questions? | Start a Chat |
Function | As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion |
Involvement in disease | Familial cold autoinflammatory syndrome 1 (FCAS1); Muckle-Wells syndrome (MWS); Chronic infantile neurologic cutaneous and articular syndrome (CINCA) |
Subcellular Location | Cytoplasm, cytosol, Inflammasome, Endoplasmic reticulum, Secreted, Nucleus |
Protein Families | NLRP family |
Tissue Specificity | Predominantly expressed in macrophages. Also expressed in dendritic cells, B- and T-cells (at protein level) (PubMed:11786556) (PubMed:17164409). Expressed in LPS-treated granulocytes, but not in resting cells (at protein level) (PubMed:17164409). Express |
Database Links |
HGNC: 16400 OMIM: 120100 KEGG: hsa:114548 STRING: 9606.ENSP00000337383 UniGene: Hs.159483 |
Recombinant Escherichia coli UDP-3-O-acyl-N-acetylglucosamine deacetylase(lpxC)
Express system: E.coli
Species: Escherichia coli (strain K12)
Recombinant Human Translation initiation factor eIF-2B subunit beta(EIF2B2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human CCAAT/enhancer-binding protein gamma(CEBPG)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Pulmonary surfactant-associated protein B(SFTPB)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Dog Matrix metalloproteinase-9(MMP9)
Express system: Yeast
Species: Canis lupus familiaris (Dog) (Canis familiaris)
Tel: 301-363-4651
Email: support@cusabio.com
Distributors Worldwide