Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)

1. A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies. PMID: 28967377
2. Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures. PMID: 28942967
3. identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding groove. PMID: 28842480
4. Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 region of the hippocampus. PMID: 27911714
5. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. PMID: 27307045
6. CN-A and nephrin were clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome. PMID: 27009276
7. that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis PMID: 26812016
8. for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT occurs via a phagosomal TLR9-dependent and Bruton's tyrosine kinase-dependent signalling pathway that is independent of MyD88 PMID: 25637383
9. Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope. PMID: 24954618
10. Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB. PMID: 25720963
11. Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 gene transcription. PMID: 25122797
12. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization. PMID: 24672054
13. These findings therefore provide initial support for the novel mechanistic hypothesis that oxidation-induced global and/or local conformational changes within calcineurin PMID: 25286016
14. PKCepsilon may negatively regulate adverse myocardial remodeling by cooperating with calcineurin to downregulate fibrosis and induce transcription of cardioprotective wound healing genes, including COX-2 PMID: 24298017
15. Mutations on the hydrophobic face of Calcineurin distal helix disrupt the structure gained upon CaM binding. PMID: 24191726
16. Bile-induced NF-kappaB activation and acinar cell injury are mediated by calcineurin. PMID: 23744075
17. Dephosphorylation of Aly1 by calcineurin serves as a regulatory switch to promote Aly1-mediated trafficking to the vacuole. PMID: 23824189
18. lower expression of PPP3CA and PPP3CB genes in atrium myocardium can be related to expressed postinfarction LV remodeling. PMID: 23888774
19. PPP3CA down-regulation is associated with hepatocellular carcinoma infected with hepatitis C virus. PMID: 23317196
20. suggest that CaMKII and calcineurin provide a switch-like mechanism that controls Ca-dependent LIMK1, SSH1L and cofilin activation, and subsequently actin cytoskeletal reorganization PMID: 22270398
21. Present findings indicate that downregulation of hemoxygenase-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factor NRF2. PMID: 22739212
22. Alterations in calcineurin signaling in the caudate nucleus contribute to the pathogenesis of schizophrenia. PMID: 22285318
23. NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy PMID: 22688515
24. calcineurin crystal of trypsin-resistant catalytic domain belonged to the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 161.6, b = 87.4, c = 112.0 A PMID: 22691791
25. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
26. Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer. PMID: 22506312
27. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
28. The authors demonstrate that the regulatory domain within calcineurin is unstructured and that it folds upon binding calmodulin, ousting the autoinhibitory domain from the catalytic site. PMID: 22100452
29. High calcineurin A alpha protein is associated with bone metastasis in small-cell lung cancer. PMID: 21785830
30. The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes. PMID: 21233773
31. Findings demonstrate that CaN functions as a critical signaling molecule during Th cell activation, regulating Bcl-10 phosphorylation and NF-kappaB activation. PMID: 21674474
32. calcineurin has a role in the heart and in cardiac disease PMID: 19879877
33. two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses) PMID: 20700529
34. data underscore the importance of calcineurin gene in the molecular mechanism of addiction and Alzheimer's diseases PMID: 20590401
35. CN mediates the Ang II-induced aldosterone synthesis through up-regulation of the CYP11B2 transcription. PMID: 20413672
36. Data show that in patients with CHF, calpain upregulation was associated with an increase in cleavage of cain/cabin1 and the activation of CaN. PMID: 20514436
37. Data suggest an association between polymorphisms in PPP3CA, PPP3R1 and PPP3R2 and baseline levels or trainability of endurance phenotype traits. PMID: 20107831
38. PP2B is an important target of the aberrant acinar cell Ca(2+) rise associated with pathological protease activation and pancreatitis. PMID: 20501444
39. Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379146
40. CnAalpha, was significantly overexpressed in lung cancer tissues with bone metastasis as compared to tumors with non-bone metastases. PMID: 20422345
41. The functional differences conferred upon CaN by the alpha or beta catalytic subunit isoforms suggest that the alpha:beta and CaN:substrate ratios may determine the levels of CaN phosphatase activity toward specific substrates. PMID: 12135494
42. involvement of PKA and PPP2B in the regulation of NF-kappaB in human monocytes PMID: 12586544
43. there is a 13-amino acid region within CN that is essential for the interaction with NFAT and with two other CN-binding proteins, AKAP79 and Cabin-1 PMID: 15671033
44. The activation of calcineurin by calpain I in the brain of patients with Alzheimer's disease is reported. PMID: 16150694
45. These results indicate that calcineurin mediates acetylcholinesterase expression during apoptosis. PMID: 17320203
46. activation of calcineurin is required for lytic granule exocytosis but it is not the sole Ca2+-dependent step PMID: 17478429
47. analysis of the secondary structure of calcineurin regulatory region and conformational change induced by calcium/calmodulin binding PMID: 18296442
48. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128
49. Study demonstrates that all CaN isoforms display the same cytoplasmic subcellular distribution and are expressed in each tested cell line, differences in substrate specificities may determine specific physiological functions of the distinct isoforms. PMID: 19154138
50. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. PMID: 19285944

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HGNC: 9314

OMIM: 114105

KEGG: hsa:5530

STRING: 9606.ENSP00000378323

UniGene: Hs.435512