Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial

Code CSB-YP011930HU
Product Type Recombinant Protein
Size US$2959
Uniprot No. P23458
Relevance Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Janus kinase 1 Short name: JAK-1
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Research Area Cancer
Source Yeast
Gene Names JAK1
Protein Names Recommended name: Tyrosine-protein kinase JAK1 EC= 2.7.10.2 Alternative name(s): Janus kinase 1 Short name= JAK-1
Expression Region 850-1154aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 36.9kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway
Subcellular Location Endomembrane system, Peripheral membrane protein
Protein Families Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Database Links

HGNC: 6190

OMIM: 147795

KEGG: hsa:3716

STRING: 9606.ENSP00000343204

UniGene: Hs.207538

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Necroptosis
Signaling pathways regulating pluripotency of stem cells
NOD-like receptor signaling pathway
Osteoclast differentiation
Th1 and Th2 cell differentiation
Th17 cell differentiation

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