Code | CSB-EP011930HU |
MSDS | |
Size | US$306 |
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The region for expressing recombinant Human JAK1 contains amino acids 850-1154. This JAK1 protein is expected to have a theoretical molecular weight of 38.9 kDa. The JAK1 protein was expressed in e.coli. The JAK1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant JAK1 protein during the following stages.
Human tyrosine-protein kinase JAK1 is a crucial enzyme involved in signal transduction and cellular responses to cytokines. As a member of the JAK family, JAK1 plays a key role in transducing signals from various cytokine receptors, including those for interleukins and interferons. Upon ligand binding to its respective receptor, JAK1 becomes activated, leading to the phosphorylation of downstream signaling molecules, particularly signal transducers and activators of transcription (STATs). This activation cascade regulates gene expression and modulates immune responses, hematopoiesis, and other physiological processes. Dysregulation of JAK1 has been linked to several diseases, making it a potential therapeutic target, especially in the context of autoimmune disorders and certain cancers.There are currently no reviews for this product.
I am interested in several of your recombinant proteins. Can you please provide some informations:
For CSB-EP011930HU (all expression systems):
a.Sequence
b.Tag type
c.Tag position
d.Sizes and formats
e.Is the protein provided soluble in solution?
f.Is the protein purified from bacterial inclusion bodies are you supplied refolded or still in urea?
g.I want to use this protein for conjugation purposes and need it supplied in an amine free buffer (so not Tris). Can you supply this protein in one of the buffers at my request: phosphate, carbonate, or borate? Would there be an extra charge?