Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Plcg1), partial

1. results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation. PMID: 28004780
2. Findings provide evidence that PLCgamma1 is critical for synaptic function and plasticity and that the loss of PLCgamma1 from the forebrain results in manic-like behavior. PMID: 28138157
3. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
4. our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development. PMID: 27759161
5. Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation. PMID: 27913297
6. study shows that PLCgamma1 controls osteoclast numbers via a CSF-1-dependent DAG/beta-catenin/cyclinD1 pathway. PMID: 27941021
7. this study shows that PLC-gamma1 contributes to protective activity of LAT activity in vivo PMID: 28063403
8. PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review] PMID: 26588873
9. FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1. PMID: 26687682
10. platelet activation through GPVI and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2. PMID: 25793864
11. foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation PMID: 25758716
12. EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase. PMID: 24687958
13. Hypoxia up-regulates PLC-gamma1 and causes intracellular calcium release in pulmonary arterial smooth muscle cells. PMID: 23204067
14. Genetic analysis shows that disease progression and ERK signaling are dependent on RasGRP1 in mutant LAT-Y136F mice. PMID: 23209318
15. These data indicate that PLC-gamma1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-gamma1. PMID: 22390417
16. parkin interacts with PLCgamma1, affecting PLCgamma1 steady state protein levels in human and murine models with manipulated parkin function and expression levels PMID: 18671761
17. The authors found that LKB1 was directly phosphorylated by Lck at tyrosine residues 36, 261, and 365 and predominately interacted with LAT and PLCgamma1 following T cell receptor stimulation. PMID: 21487392
18. propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCgamma1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis PMID: 21242968
19. Phosphatidylinositol-specific phospholipase C (PLC)-gamma was identified as a partner of the Spry1 and Spry2 proteins. PMID: 20719962
20. PLCgamma1 is essential for T cell development, activation, and tolerance PMID: 20123962
21. Data show that endothelial cells can be instructed to engage a phospholipase Cgamma-dependent intrinsic destabilization pathway that results in the production of soluble regression factors such as autotaxin and lysophosphatidic acid. PMID: 20231358
22. We conclude that TrkB-dependent activation of PLCgamma1 signaling is an important molecular mechanism of limbic epileptogenesis PMID: 20445044
23. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity PMID: 11886851
24. Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway. PMID: 11916959
25. Phospholipase C-gamma1 is required for cell survival in oxidative stress by protein kinase C. PMID: 11931670
26. Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts PMID: 11934646
27. PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion PMID: 11973363
28. EGF-inducible direct association of PLC-gamma1 with c-Cbl in vivo that is mediated by the SH3 domain of PLC-gamma1. PMID: 12061819
29. PLC gamma 1 status could greatly influence the post-DNA damage cellular response to ionizing radiation PMID: 12149210
30. PLCgamma1 is present from E13 to E18 but drops off precipitously to negligible levels on the day of birth and thereafter in submandibular gland PMID: 12761849
31. investigated host-cell signalling events mediated by phospholipase C gamma in enterocytes upon interaction with anaerobically grown Salmonella typhimurium PMID: 12909648
32. PLC gamma-dependent component of Fc epsilon RI-mediated calcium flux leading to degranulation of mast cells is independent of PI 3-kinase PMID: 13129935
33. requirement for PLC-gamma(1) in antigen receptor induced Ca(++) signaling PMID: 14687726
34. Tyr-783 phosphorylation of of phospholipase C-gamma 1 is not sufficient for enzyme activation PMID: 15161916
35. possibility that the C-terminal tyrosine 438 of the CCK2 receptor associates with the SH2 domains of phospholipase C gamma1 was examined PMID: 15196926
36. Epo-R, TRPC2, PLCgamma, and IP(3)R interact to form a signaling complex. PMID: 15329338
37. SHP-2 has a role in regulating IL-1-induced Ca2+ flux and ERK activation via phosphorylation of PLCgamma1 PMID: 15563458
38. The SH2 domains of PLC-gamma1 were required for maximal adhesion on fibronectin. PMID: 15657076
39. PLCgamma1 in cell motility, functioning as a mediator of both growth factor and integrin-initiated signals PMID: 15944397
40. a novel adapter function in erythropoietin signaling PMID: 15953601
41. PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions. PMID: 17015722
42. Plcg1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation. PMID: 17531443
43. The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1. PMID: 17562871
44. Plcg1 signalling regulates lipopolysaccharide-induced Ptgs2 protein expression in cardiomyocytes. PMID: 17655858
45. PLCgamma1 signalling induces cardiac TNF-alpha expression and myocardial dysfunction during LPS stimulation. PMID: 18079103
46. Neuronal surface sialylation and fucosylation are regulated via PLCgamma by L1, modulating neurite outgrowth, cell survival and migration. PMID: 19048108
47. Nephrin Tyr-1204 phosphorylation triggers the Ca(2+) response in a PLC-gamma1-dependent fashion. PMID: 19179337
48. Results suggest a negative regulatory role for PLC-gamma1 in cell aggregation by controlling the secretion of fibronectin into the media and its assembly into fibrils. PMID: 19379731
49. VEGFR2-PLCgamma1 signal relay gives rise to the unique function of VEGFR2, thus enabling endothelial differentiation from vascular progenitors. PMID: 19706681
50. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. PMID: 19717566

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KEGG: mmu:18803

STRING: 10090.ENSMUSP00000099404

UniGene: Mm.44463