Recombinant Mouse Protein c-Fos (Fos)

1. our data suggested that purpurogallin inhibits osteoclast differentiation via downregulation of c-Fos and NFATc1 PMID: 29463002
2. Both cyclic AMP responsive element binding protein (CREB)-dependent transcription and CPEB4-promoted translation support c-FOS expression early postnatal olfactory bulbs but disengage in adult olfactory bulbs PMID: 29166615
3. We demonstrate that overexpression of Gfi1b, c-Fos, and Gata2, previously reported to transdifferentiate fibroblasts into hematopoietic progenitors in vitro, can induce long-term HSC formation in vivo. PMID: 28943250
4. these data demonstrated that wedelolactone facilitated osteoblastogenesis through Wnt/GSK3beta/beta-catenin signaling pathway and suppressed RANKL-induced osteoclastogenesis through NF-kappaB/c-fos/NFATc1 pathway. PMID: 27558652
5. The data of this study suggest that Fos expression during simple associative learning labels ensembles activated generally by arousal rather than specifically by a particular sensory cue. PMID: 28331016
6. The specific expression of this long MEX3C isoform in oocytes and its ability to enhance FOS mRNA nuclear export and stability all suggest that MEX3C(659AA) is an RNA-binding protein that preserves maternal FOS mRNA in oocytes. PMID: 27053362
7. we performed cotransfections of AP-1 expression plasmids with different mouse Gja1 promoter/luciferase reporter constructs within TM3 Leydig and TM4 Sertoli cells.We showed that a functional cooperation between cJun and cFos activates Gja1 expression and requires an AP-1 DNA regulatory element located between -132 and -26 bp PMID: 28903063
8. hypergravity down-regulated c-fos expression transiently via ROCK/Rho-GTP and PI3K signaling. PMID: 28953959
9. These findings suggested that the photoreceptor c-Fos controls blood vessel growth into the normally avascular photoreceptor layer through the inflammatory signal-induced STAT3/VEGFA pathway. PMID: 28465464
10. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias. PMID: 28319094
11. the protein and RNA levels of RANKLinduced cFos and nuclear factor of activated T-cell cytoplasmic 1 were suppressed by centipedegrass extract (CGE). These results indicated that CGE may serve as a useful drug in the prevention of bone loss. PMID: 27035226
12. Fos and phosphorylation of extracellular signal-regulated kinases (ERK) were used to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine. PMID: 27270268
13. this study shows that the inhibitory effect of tatrinan O on osteoclast formation is via decreasing the expression of NFATc1 and c-Fos PMID: 26971224
14. The study quantified monosodium glutamate (MSG)--evoked brain activity, as measured by c-Fos, in the nucleus of the solitary tract (nTS). The number and pattern of c-Fos neurons in the nTS of animals that were water-restricted and received a constant infusion of MSG via intraoral cannula most closely mimicked animals that consumed MSG from a bottle. PMID: 26762887
15. these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis PMID: 26627060
16. Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element. PMID: 26259236
17. this is the first report implicating M-CSF/DGKzeta/DAG axis as a critical regulator of bone homeostasis via its actions on OC differentiation and c-Fos expression. PMID: 25891971
18. An intriguing finding was that S1P induced c-Fos-inhibited CCL5 directly and also indirectly through inhibition of the IFN-beta amplification loop PMID: 26246404
19. These results suggest that c-Fos is involved in the normal development of Neural Stem Progenitor Cells PMID: 26143639
20. Mechanistically, mTOR plays a crucial role in c-fos expression, thereby modulating NFkappaB binding to promoters of IL-12 and IL-10. PMID: 26122641
21. cFOS plays a cell-specific role at multiple levels of the hypothalamic-pituitary-gonadal axis, affecting gonadotropes but not thyrotropes in the pituitary, and kisspeptin neurons but not GnRH neurons in the hypothalamus. PMID: 25958044
22. These results suggest that TGF-beta regulates RANKL-induced osteoclastogenesis through reciprocal cooperation between Smad2/3 and c-Fos. PMID: 25431176
23. measured gene expression of Fos, Per1 and Sgk1 45 min after exposure to brief cold swim stress in male and female mice; stress induced a stronger increase in Fos and Per1 expression in females than males PMID: 25459888
24. Transcriptional activity of early genes involved in memory process, such as FBJ osteosarcoma oncogene (Fos) is increased in the hippocampus of hypercholesterolemic LDL receptor knockout mice. PMID: 25797218
25. Spontaneous seizures in Kcna1-null mice activate Fos expression in select limbic circuits PMID: 26112121
26. c-Fos expression in the dorsal hippocampus of Gria1-/- mice PMID: 25446922
27. This study finding of a correlation between SERT and c-FOS protein expression affected by PS, together with related mRNAs. PMID: 25102410
28. Results show a difference in Fos expression in the hippocampus between B6 and D2 mice after 1 flurothyl-induced seizure PMID: 25524858
29. Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation. PMID: 25173565
30. Data suggest that p38 MAP kinase regulates c-fos/cellular oncogene fos mRNA stability/decay by affecting state of phosphorylation of Elavl1/HuR (Hu antigen R). PMID: 25588078
31. c-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). PMID: 25208928
32. Pik3cd inactivation leads to extracellular matrix degradation in vessels and promotes aneurysm development by inducing macrophage migration and upregulating the activator protein-1/MMP-12 pathway in macrophages. PMID: 25503990
33. The results of this study conclude that fosGFP expression discriminates between single- and multi-whisker receptive field layer 2 pyramidal neurons. PMID: 25453844
34. Data suggest that c-Fos (not c-Jun) regulates phospholipid synthesis in cell nucleus; c-Fos localizes to nucleus and modulates genetic transcription through activation of Pip5k1 (phosphatidylinositol-4-monophosphate 5-kinase). PMID: 24819416
35. the distinct requirement of NF-kappaB for mouse and human c-fos regulation PMID: 24386331
36. The expression of the c-fos gene increased the most among phencyclidine-dependent differentially expressed genes between WT and GluN2D knockout out mice. PMID: 24330819
37. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PMID: 23967313
38. analysis of the temporal pattern in cfos activation in cortical and brainstem areas implicated in the control of appetite and body weight regulation PMID: 24424063
39. Using transgenic mice overexpressing the AP-1 inhibitor JDP2, a central role of AP-1 in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated. PMID: 23612584
40. Orientation within a high magnetic field determines swimming direction and c-Fos induction in brain stem vestibular nuclei. PMID: 23720133
41. c-Fos transcriptionally controls mmp10 and s100a7a15 expression in keratinocytes, subsequently leading to CD4 T-cell recruitment to the skin, thereby promoting epidermal hyperplasia that is likely induced by CD4 T-cell-derived IL-22 PMID: 24029918
42. the restructuring of muscarinic receptor mRNA correlations reveals an additional mechanism for adaptation to the c-fos gene knockout PMID: 23395867
43. The inhibitory effect of inflammation and tensile strain on osteogenicity is associated with the upregulation in c-fos expression. PMID: 23727355
44. this study examined c-Fos expression induced by repeated maternal separation andsingle time maternal separation in pre-weaned mice, with the aim of determining whether newborn animals become desensitised to repeated maternal absence. I PMID: 22913644
45. the role of GnRH in the regulation of gonadotropin gene expression is seen by highlighting the role of c-Fos posttranslational modification that may cause higher levels of FSH during the time of low GnRH pulse frequency to stimulate follicular growth. PMID: 23275456
46. c-Fos and polo-like kinase 2 induction is impaired in the limbic system of fear-conditioned alpha-synuclein transgenic mice PMID: 23209687
47. Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis. PMID: 23340137
48. ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-kappaB and induction of c-Fos and NFATc1. PMID: 23246654
49. Data suggest that miR-181a attenuates ox-LDL-stimulated immune inflammation responses by targeting c-Fos in dendritic cells. PMID: 22956783
50. hypothalamic c-Fos activation is regulated by daily scheduled high fat meals in mice PMID: 22815954

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KEGG: mmu:14281

STRING: 10090.ENSMUSP00000021674

UniGene: Mm.246513