FOS Research Reagents

Proto-oncogene c-Fos is a protein in humans that is encoded by FOS gene. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A.

The following FOS reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FOS Antibodies

FOS Antibodies for Homo sapiens (Human)

FOS Proteins

FOS Proteins for Gallus gallus (Chicken)

FOS Proteins for Rattus norvegicus (Rat)

FOS Proteins for Mus musculus (Mouse)

FOS Proteins for Homo sapiens (Human)

FOS Proteins for Ovis aries (Sheep)

FOS Proteins for Bos taurus (Bovine)

FOS Proteins for Sus scrofa (Pig)

FOS Proteins for Cyprinus carpio (Common carp)

FOS Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

FOS Proteins for Mesocricetus auratus (Golden hamster)

FOS Proteins for Phodopus roborovskii (Roborovski's desert hamster) (Cricetulus roborovskii)

FOS Proteins for Phodopus campbelli (Campbell's dwarf Russian hamster)

FOS Proteins for Felis catus (Cat) (Felis silvestris catus)

FOS Proteins for Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)

FOS Background

Proto-oncogene c-Fos is a protein in humans that is encoded by FOS gene [1]. As a nuclear phosphoprotein, c-Fo forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex, which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression [2]. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers [3]. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half-sites. On TGF-beta activation, c-Fo forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. c-Fos has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation, and differentiation. In growing cells, c-Fos activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A.

[1] Curran T. The c-fos proto-oncogene. In: Reddy EP, Skalka AM, Curran T (eds.). The Oncogene Handbook 1988 Elsevier, New York, pp 307–327.
[2] Chiu R, Boyle WJ, et al. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes [J]. Cell. 1998, 54 (4): 541–52.
[3] Milde-Langosch K. The Fos family of transcription factors and their role in tumourigenesis [J]. Eur. J. Cancer. 2005, 41 (16): 2449–61.

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