Recombinant Mouse Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Ppp3ca)

1. calcineurin is a key regulator of Wnt5a-induced AQP2 activation without affecting intracellular cAMP level and PKA activity. PMID: 27892464
2. these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells PMID: 27301880
3. the CaN-Nfat pathway regulates development and function of IFN-gamma-producing gammadelta T cells. PMID: 28062573
4. the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment. PMID: 27171192
5. Calcineurin inhibitor tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin at the slit diaphragm. PMID: 27009276
6. global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity PMID: 26411342
7. Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy. PMID: 26031702
8. Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression PMID: 26029823
9. Data indicate that calcineurin (CnAalpha-/- or CnAbeta-/-) is required for pathological but not compensatory renal hypertrophy. PMID: 25287476
10. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin activity in HEK293T cells PMID: 25193101
11. Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. PMID: 24838101
12. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization. PMID: 24672054
13. Data indicate that reduction in connexin43 (Cx43) and sodium channel NaV1.5 expression coincided with overexpression of transgene calcineurin A (CnA) and hypertrophy development and preceded significant presence of fibrosis. PMID: 24498049
14. Calcineurin regulates Nirr1 expression in a cell-autonomous, neural activity-dependent manner. PMID: 24291696
15. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. PMID: 24526353
16. Defects in renal development and function persist in adult calcineurin A subunit alpha -/- mice including a significant decrease in glomerular filtration rate and an increase in blood urea nitrogen levels. PMID: 23638102
17. In calcineurin knock-out mice, an impairment of synaptic vesicle release was found in prefrontal cortex. PMID: 23825400
18. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
19. Calcineurin is essential for gonadotropin-releasing hormone-induced expression of TORC1 and Nur77. PMID: 21986493
20. These data suggest that Gq stimulates CN and promotes podocyte apoptosis both in vitro and in vivo. PMID: 21622531
21. Results indicate that myospryn functions as a novel inhibitor of the calcineurin signaling pathway in skeletal muscle. PMID: 21427212
22. Inhibition by IL-2 occurred via a natural killer cell-independent component of the calcineurin pathway, and CD94/NKG2A induction was markedly enhanced in the presence of calcineurin blockers PMID: 21540458
23. calcineurin has a role in digestion and protein trafficking PMID: 21435446
24. Normal, opposing circadian oscillations in calcineurin-dependent activities and phosphorylation of proteins that regulate contractility are disrupted in heart failure. PMID: 21233454
25. in response to transverse aortic constriction, time-dependent changes in Akt/GSK3beta and calcineurin/NFAT signalling occur with varying amplitudes that structure the progression towards HF as a 3-stage process. PMID: 21076497
26. identification of Cryab as a downstream effector of calcineurin-related protection against myocardial apoptosis PMID: 20937869
27. Calcineurin protects the heart in a murine model of dilated cardiomyopathy PMID: 19854199
28. calcineurin has a role in the heart and in cardiac disease PMID: 19879877
29. calcineurin activation in skeletal muscle increases mitochondrial oxidative function and energy substrate storage, which contributes to enhanced endurance exercise performance PMID: 19861587
30. Plasma renin concentrations were not different in wild-type, calcineurin A-alpha, or A-beta knockout mice. PMID: 19907416
31. calcineurin Aalpha activity is required for the normal differentiation and survival of epidermal cells PMID: 19626032
32. Calcineurin Aalpha is important for mature T cell function, but has a limited role in thymocyte development. PMID: 11981809
33. a trimeric-interaction among calcineurin, FKBP12, and RyR is important for the regulation of the RyR channel activity and may play an important role in the Ca(2+) signaling of muscle contraction and relaxation PMID: 12414688
34. calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli PMID: 15082723
35. absence of CnA-alpha but not CnA-beta leads to a defect in normal maturation of the NZ and glomeruli, alterations in the cell cycle, and impaired kidney function PMID: 15509543
36. CnAalpha is required for normal intracellular trafficking of AQP2 and loss of calcineurin protein or activity disrupts AQP2 function. PMID: 16735444
37. Increased calcineurin activity may confer functional benefits to dystrophic skeletal muscles. PMID: 16793906
38. Calcineurin A (CnA) alpha (-/-) mice display renal hypoplasia associated with the ectopic expression of p27. PMID: 17072859
39. calcineurin activation can confer structural and functional benefits to regenerating skeletal muscles, which may be mediated in part by differential expression of myoregulatory factors PMID: 17475677
40. Calcineurin acts as a signal to up-regulate the fast-oxidative MyHC2a gene and to down-regulate the faster MyHC2x and MyHC2b genes in a manner that appears to be NFAT-independent. PMID: 17587059
41. PPP3ca was highly expressed during the stages of the seminiferous epithelium most sensitive to low doses of cadmium chloride. PMID: 17785681
42. Cholecystokinin activates NFATs in a calcineurin-dependent manner, both in vitro and in vivo. PMID: 17978097
43. a decrease in fiber cross-sectional area, normalized force was lower in fast- and slow-twitch muscles of mdx ppp3ca knockout than mdx mice PMID: 18199592
44. Haploinsufficiency of calcineurin A-alpha causes upregulation of TGF-beta which contributes to chronic inflammation and formation of tertiary lymphoid organs. PMID: 19129256
45. Data suggest that the regulation of cytoglobin transcription by calcineurin-dependent transcription factors suggests that cytoglobin may have a functional role in calcium-dependent events accompanying cardiac remodeling. PMID: 19203999

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KEGG: mmu:19055

STRING: 10090.ENSMUSP00000053101

UniGene: Mm.331389