Recombinant Mouse cAMP-dependent protein kinase catalytic subunit alpha (Prkaca)

1. The cooperativity mechanism of Pkaca critically depends on the presence of water in two distinct, buried hydration sites. PMID: 29581285
2. Study validates the DNAJB1-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin. PMID: 29162699
3. Protein kinase A signaling explains vasopressin-mediated regulation of membrane trafficking and gene transcription. PMID: 28973931
4. Data suggest that the Girvan-Newman algorithm-based community maps of the kinase domain of cAMP-dependent protein kinase A (PKA) allow for a molecular explanation for the role of protein conformational entropy in its catalytic cycle. PMID: 28115705
5. Acute versus chronic exposure to high fat diet leads to distinct regulation of PKA. PMID: 28420713
6. Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling. PMID: 29038164
7. HIF1a transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation PMID: 27245613
8. Generation of the Dnajb1-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma. PMID: 28923495
9. Data indicate a subpopulation of the CaV1.2 channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes. PMID: 28119464
10. S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Cav1.2 and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade. PMID: 28119465
11. study identifies a new role of Dual-AKAP1 in regulating mitochondrial trafficking through Miro-2, and supports a model in which PINK1 and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity PMID: 28556983
12. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit) PMID: 28661131
13. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing. PMID: 27720745
14. this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor DNA methylation resulting in macrophage maturation PMID: 27353657
15. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK signaling cascade. PMID: 27156838
16. These data indicate that LPA increases CCN2 expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 expression PMID: 26743816
17. PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase. PMID: 26387949
18. Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics. PMID: 26618408
19. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone. PMID: 26488807
20. Lin28a protects against DCM through PKA/ROCK2 dependent pathway. PMID: 26626075
21. Findings show that cAMP acts via protein kinase A (PKA) to regulate multiple aspects of mitochondrial function and structure. PMID: 26203188
22. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors. PMID: 25933021
23. Data suggest that investigation of cAMP-dependent protein kinase A (PKA) and its signaling in D2 receptor-expressing indirect pathway medium-sized spiny neurons (iMSNs) would better understand the mechanisms underlying psychiatric disorders. PMID: 26305972
24. This study investigates the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations. PMID: 25275314
25. Our results provide evidence that cSrc is activated downstream of PKA and that inhibition of its activity blocks the capacitation-induced hyperpolarization of the sperm plasma membrane . PMID: 26060254
26. Upon ligand and pseudosubstrate binding, the hydrogen bond networks undergo extensive reorganization, revealing that the open-to-closed transitions require global rearrangements of the internal forces that stabilize the enzyme's fold. PMID: 26030372
27. Collectively, our studies highlighted that the CuB-induced actin aggregation and cofilin-actin rod formation was mediated via the Ga13/RhoA/PKA/VASP pathway. PMID: 24691407
28. Angiotensin II activates PKA and CaMKII via NOX2, which results in disturbed sodium and calcium currents (via PKA) and enhanced diastolic sarcoplasmic reticulum Calcium leakage. PMID: 25073061
29. protein kinase A and perilipin 5 interact to regulate cardiac lipolysis PMID: 25418045
30. Data indicate that Ppif protein cyclophilin D (CypD)-dependent protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signaling is responsible for amyloid beta (Abeta)-induced synaptic injury. PMID: 23507145
31. The findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration. PMID: 24905167
32. A dominant-negative Rad mutation causes arrhythmogenesis via PKA-mediated phosphorylation of RYR2 activity in the heart. PMID: 25193703
33. PKA turnover by the REGgamma-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. PMID: 24560667
34. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PMID: 24643070
35. nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1) PMID: 24556414
36. Data indicate mutation of the beta1 adrenergic receptor (beta1AR) promotes sustained agonist-induced cAMP activity, protein kinase A (PKA) phosphorylation, and cardiac myocyte contraction response. PMID: 24713698
37. Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5. PMID: 24828496
38. Data indicate that high protein kinase A (PKA) activity correlated negatively with migration velocity. PMID: 24842369
39. The dynamic mitochondrial-nuclear shuttling of FKBP51 regulated by PKA may be key in fine-tuning the transcriptional control of glucocorticoid receptor target genes required for the acquisition of adipocyte phenotype. PMID: 24101724
40. protein kinase A (PKA) inhibits potassium currents activated by protein kinase C (PKC) in freshly isolated aortic myocytes. PMID: 24086441
41. Studied Ssanghwa-tang alpha-MSH-induced melanogensis and its mechanisms of action in murine B16F10 melanoma cells. Ssanghwa-tang efficiently inhibited c-AMP-induced melanin synthesis in B16F10 cells via suppression of PKA and p38 MAPK signaling pathways. PMID: 23981281
42. These data imply that the protein kinase A and mTOR signaling cascades are important for the development of follicular thyroid carcinogenesis and may suggest new targets for therapeutic intervention. PMID: 24512487
43. PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. PMID: 24260568
44. Chondrogenesis induced by PTH in mesenchymal progenitor cells is mediated by Runx1, which involves the activation of PKA. PMID: 24058535
45. The new transcript variant encoding Calpha3 isoform has N-terminus that differs from Calpha1 and Calpha2 isoforms. PMID: 23456795
46. Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses. PMID: 23965992
47. Data indicate that TRPV4 activity and TRPV4 trafficking are under discrete but synergistic control of PKC- and PKA-dependent pathways. PMID: 23709216
48. A PKA-mediated signaling pathway mediates GnRH activation of CREB at low-pulse frequencies, playing a significant role in the decoding of the hypothalamic GnRH signal to result in frequency-dependent FSHbeta activation. PMID: 23393127
49. Data show that in skeletal muscle cells, oleic acid induces cAMP/PKA and SIRT1 Ser-434 phosphorylation and activity, causing PGC1alpha deacetylation and increased fatty acid oxidation. PMID: 23329830
50. Use constitutively active PKA catalytic subunit to show that PKA/CREB signaling may be a very early regulator of endothelial and hematopoietic cell differentiation. PMID: 22267325

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KEGG: mmu:18747

STRING: 10090.ENSMUSP00000005606

UniGene: Mm.19111