Product Type | Recombinant Protein |
Uniprot No. | Q5R6J5 |
Abbreviation | CCND1 |
Species | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Gene Names | CCND1 |
Protein Names | Recommended name: G1/S-specific cyclin-D1 |
Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). |
Subcellular Location | Nucleus, Cytoplasm, Membrane |
Protein Families | Cyclin family, Cyclin D subfamily |
Database Links |
KEGG: pon:100171625 STRING: 9601.ENSPPYP00000003434 UniGene: Pab.10369 |
Pathway |
Hedgehog signaling pathway
Hippo signaling pathway Jak-STAT signaling pathway p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Focal adhesion Cell cycle Cellular senescence AGE-RAGE signaling pathway in diabetic complications AMPK signaling Apelin signaling pathway FoxO signaling pathway |
Product Name | Recombinant Pongo abelii G1/S-specific cyclin-D1(CCND1),Yeast |
Code | CSB-YP728931PYX |
Size | Pls inquiry other sizes |
Source | Yeast |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAALTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NSFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI |
Expression Region | 1-295 |
Protein Description | full length protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pongo abelii G1/S-specific cyclin-D1(CCND1),E.coli |
Code | CSB-EP728931PYX |
Size | Pls inquiry other sizes |
Source | E.coli |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAALTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NSFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI |
Expression Region | 1-295 |
Protein Description | full length protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pongo abelii G1/S-specific cyclin-D1(CCND1),Baculovirus |
Code | CSB-BP728931PYX |
Size | Pls inquiry other sizes |
Source | Baculovirus |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAALTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NSFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI |
Expression Region | 1-295 |
Protein Description | full length protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pongo abelii G1/S-specific cyclin-D1(CCND1),Mammalian cell |
Code | CSB-MP728931PYX |
Size | Pls inquiry other sizes |
Source | Mammalian cell |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAALTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NSFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI |
Expression Region | 1-295 |
Protein Description | full length protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
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