Recombinant Rat Inositol 1,4,5-trisphosphate receptor type 3 (Itpr3), partial

1. An age-related decline in IP3R3 expression and NPY signaling underlie age-related homeostatic changes and olfactory dysfunction. PMID: 25482245
2. It regulates calcium transients in neonatal rat ventricular myocytes.(37-46) PMID: 25242084
3. Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3R3. PMID: 24469450
4. A phosphomimetic mutation at T-930 of the rat Ins(1,4,5)P 3 receptor results in decreased Ins(1,4,5)P 3-dependent Ca ( 2+) release and lowers the Ins(1,4,5)P 3 binding affinity of the receptor. PMID: 22878752
5. Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine signaling pathway that involves CFTR, apical release of ATP, stimulation of apical nucleotide receptors, and then activation of apical, type III InsP3Rs. PMID: 17916355
6. After apoptosis induction calcium permeability of the nuclear calcium store vesicles increases via IP(3) receptor translocation to nucleus. PMID: 21302308
7. Sulfhydryl redox modification can regulate various aspects of intracellular Ca2+ signaling, including quantal Ca2+ release, by tuning ligand sensitivities of InsP3R channels. PMID: 20643058
8. findings show that repeated exposure to amphetamine causes sensitization of IP3 receptors in ventral tegmental area dopamine neurons, resulting in an enhancement of mGluR-dependent NMDA receptor LTP PMID: 20463231
9. regulation of type 3 inositol trisphosphate receptors by cytosolic calcium PMID: 11875073
10. the injurious effects of Ca2+i in traumatic central nervous system (CNS) white matter injury appear to be mediated both by RyRs and through IP3Rs calcium-induced calcium release receptors (CICRs) PMID: 11939501
11. analysis of binding affinity of inositol 1,4,5-trisphosphate (IP(3)) receptors from cerebellum to adenophostin A PMID: 12088506
12. Expression of the rat type-3 IP3R in IP3R-KO chicken cells rescued agonist-dependent intracellular Ca2+ release & Ba2+ influx. PMID: 12198155
13. inositol 1,4,5-trisphosphate (IP(3)) receptor is selectively phosphorylated by cGMP-dependent protein kinase in intact smooth muscle resulting in inhibition of IP(3)-dependent Ca(2+) release PMID: 12529267
14. in taste buds, a large subset of type II cells and a small subset of type III cells display IP(3)R3 immunoreactivity within their cytoplasm PMID: 14681927
15. IP3-dependent conformational change in the IP3R, not endoplasmic reticulum Ca2+ pool release, triggers agonist induced CA2+ entry. PMID: 14983008
16. Overexpression of RACK1 or depletion of RACK1 by interference RNA markedly augments or diminishes Ca2+ release. PMID: 14983009
17. strong evidence that IP3Rs are required for BCR (B-cell receptor)-mediated Ca2+ entry in DT40 cells PMID: 15175012
18. Data show that phosphorylation of 1,4,5-trisphosphate receptor (IP(3)R)1 by protein kinase C was about eight times stronger than that of IP(3)R3 under identical conditions. PMID: 15184066
19. The 3 phosphorylation sites of IP3R, all of shich are located close to a putative surface-exposed peptide loop, are described. PMID: 16107208
20. the finding that interactions between protein 4.1N and the 1,4,5-trisphosphate receptor vary among cell types may provide an additional, tissue-specific mechanism to shape the pattern of Ca2+ waves. PMID: 16122796
21. Data show that IP3R3-mediated Ca2+ mobilization is unaffected by phosphorylation of S916, S934, and S1832, and suggest that modification of Ca2+ flux may not be the primary effect of IP3R3 phosphorylation by PKA. PMID: 17257671
22. These results suggest the existence of a negative feedback mechanism involving two components of the Ca2+ signalling cascade, whereby activated PKC dampens IP3R-3 activity. PMID: 17320950
23. Transient upregulation of postsynaptic IP3 receptor-gated calcium signaling constitutes a novel form of short-term synaptic plasticity. PMID: 18434513
24. the mechanism responsible for augmenting InsP(3)R-1 channel activity following phosphorylation PMID: 18535093
25. findings show that changes in cellular oxidation/reduction balance during hypoxia increase cytosolic NAD(P)H, and that this triggers the release of Ca2+ from the endoplasmic reticulum via activation of IP3 receptors PMID: 19217932
26. we determined the interaction between zonisamide and inositol-1,4,5-triphosphate receptor (IP3R) on exocytosis of neurotransmitters in rat frontal cortex. PMID: 19429061

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KEGG: rno:25679

STRING: 10116.ENSRNOP00000011516

UniGene: Rn.11242