Code | CSB-RA260702A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The production of the ACVR2B recombinant monoclonal antibody involves a complex procedure that requires several stages. Initially, the ACVR2B monoclonal antibody is collected, and its gene sequence is determined. Following that, a vector carrying the ACVR2B monoclonal antibody gene is designed and transfected into a host cell line for culturing. During the ACVR2B monoclonal antibody synthesis, a synthesized peptide based on human ACVR2B is employed as an immunogen. The ACVR2B recombinant monoclonal antibody is then separated and purified through affinity chromatography from the cell culture supernatant. Finally, the specificity of the ACVR2B recombinant monoclonal antibody is confirmed using ELISA and IHC techniques. It only detects human ACVR2B protein.
ACVR2B is well-known for its role in the regulation of muscle growth and development. By binding to myostatin, ACVR2B inhibits the activity of skeletal muscle satellite cells, which are responsible for muscle repair and growth, leading to a decrease in muscle mass. ACVR2B is also involved in bone development and homeostasis, as it can bind to BMPs and regulate osteoblast and osteoclast activity. It has been implicated in various other physiological processes, including neural development, immune system regulation, and tumorigenesis.
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