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In the production of the BAX recombinant monoclonal antibody, in vitro expression systems are utilized, entailing the cloning of BAX antibody DNA sequences from immunoreactive rabbits. The immunogen used is a synthesized peptide derived from the human BAX protein. Subsequently, the genes encoding the BAX antibodies are inserted into plasmid vectors, and these recombinant plasmid vectors are transfected into host cells to enable antibody expression. Following expression, the BAX recombinant monoclonal antibody is purified through affinity chromatography and subjected to extensive testing in ELISA, IHC, and FC applications. These tests affirm its reactivity with the human BAX protein.
BAX is a critical regulator of apoptosis, promoting programmed cell death in response to various cellular signals and stressors. Its functions are essential for tissue homeostasis, the removal of damaged or unwanted cells, and the prevention of diseases such as cancer. BAX and other Bcl-2 family members help maintain the balance between cell survival and cell death in multicellular organisms.
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