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The anti-CD44 antibody is a CD44-specific recombinant monoclonal antibody. This CD44 antibody was extracted from the tissue culture supernatant (TCS), which was used to develop cell lines with human CD44 monoclonal antibody gene-vectors. It was purified using affinity chromatography. It's a rabbit IgG. It is also reactive with human samples for ELISA, WB, and IHC testing.
Because of its diverse structure and distribution in bodily tissues, CD44 has a wide range of functions, including cellular adhesion, hyaluronate degradation, lymphocyte activation, lymph node homing, myelopoiesis, lymphopoiesis, angiogenesis, and cytokine release. In many types of malignancies, CD44 has been chosen as a surrogate marker for cancer stem cells (CSCs). CD44 promotes tumor invasion and metastasis by assisting tumor cells in adherence to endothelium and fibronectin-rich matrices.
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