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The GFAP recombinant monoclonal antibody is produced through a comprehensive process that includes in vitro cloning, where genes for both the heavy and light chains of the GFAP antibody are inserted into expression vectors. These recombinant vectors are subsequently transfected into host cells to enable the recombinant expression of the antibody in a cell culture setting. After expression, the GFAP recombinant monoclonal antibody is purified from the supernatant of transfected host cell lines using affinity chromatography. This purified antibody demonstrates specific reactivity with the human GFAP protein and exhibits versatility by being suitable for ELISA and FC applications.
GFAP is primarily associated with astrocyte function and is essential for the structural support, morphology, and various roles of astrocytes in the central nervous system. It contributes to the maintenance of the blood-brain barrier, ion and water homeostasis, neurotransmitter uptake, and neuroprotection. Additionally, GFAP expression increases during reactive gliosis in response to CNS injuries or diseases, where it plays a role in glial scar formation and the brain's response to damage.
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