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CUSABIO produced the HSP90AA1 recombinant monoclonal antibody using DNA recombinant technology and in vitro genetic manipulation. Initially, an animal is immunized with a synthesized peptide derived from human HSP90AA1, and B cells are isolated and selected based on their reactivity. Positive B cells are further screened and undergo single clone identification. The genes encoding the light and heavy chains of the HSP90AA1 antibody are amplified using PCR and inserted into a plasmid vector to create a recombinant vector. This vector is then transfected into a host cell line for the expression of the HSP90AA1 antibody. The HSP90AA1 recombinant monoclonal antibody is purified from the cell culture supernatant using affinity chromatography. It is specifically designed to bind to both human and rat HSP90AA1 protein and is highly suitable for ELISA, WB, IHC, IF, and IP applications.
The HSP90AA1 protein is a molecular chaperone that plays a crucial role in cellular homeostasis and protein folding. In cells, the HSP90AA1 protein participates in various cellular processes, including cell cycle control, signal transduction, protein degradation, and DNA repair. It assists in maintaining the proper conformation and function of client proteins, facilitating their transport to specific subcellular compartments and protecting them from degradation. Disruption of HSP90AA1 function can have profound effects on cellular processes and has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
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