Code | CSB-RA002791A401phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
IF | 1:20-1:200 |
CUSABIO designed the vector clones for the expression of a recombinant BRAF antibody in mammalian cells. The vector clones were obtained by inserting the BRAF antibody heavy and light chains into the plasma vectors. The recombinant BRAF antibody was purified from the culture medium through affinity-chromatography. It can be used to detect BRAF protein from Human in the ELISA, WB, IF.
Anti-phospho-specific T401 BRAF antibody can recognize the BRAF protein phosphorylated at T401 residue. BRAF is a core component of the RAS-RAF-MEK-ERK signaling cascade that is involved in the control of various cell activities including cell proliferation, survival, differentiation, and migration. Phosphorylation of BRAF at T401 by activated ERK contributes to the RAF dimerization. Studies have shown that the calcineurin target reside on BRAF is T401, a site of negative feedback phosphorylation by ERK1/2. Phosphorylated BRAF at T401 and S419 residues are somatically mutated in tumors.
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