Code | CSB-RA008836A253phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The synthesized DNA sequence corresponding to the phospho-FOXO3 (S253) monoclonal antibody was cloned into the plasmid and then transfected into the cell line for expression. The product was purified through the affinity-chromatography method and obtained the phospho-FOXO3 (S253) recombinant monoclonal antibody. This FOXO3-pS253 recombinant antibody is a rabbit IgG and has been tested in scientific applications, including ELISA, WB, and IHC. It can be used to detect the human FOXO3 phosphorylated at Ser253 residue.
FOXO3 is a transcription factor that controls a variety of physiological processes such as cell cycle arrest, apoptosis, oxidative stress response, and energy consumption. Various post-translational modifications, such as acetylation, ubiquitination, and phosphorylation, regulate FOXO3. AKT phosphorylates FOXO3 at T32 and S253, forming 14-3-3 binding sites, which modulates FOXO3 transcriptional activity and localization.
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