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CUSABIO cloned PTEN antibody-coding genes into plasma vectors and then transfected these vector clones into mammalian cells using a lipid-based transfection reagent. Following transient expression, the recombinant antibodies against PTEN were harvested and characterized. The recombinant PTEN antibody was purified by affinity-chromatography from the culture medium. It can be used to detect PTEN protein from Human in the ELISA, WB.
PTEN is a protein-coding gene that encodes Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN. Disorders associated with PTEN include Cowden syndrome 1 and macrocephaly/autism syndrome. Its related pathways include metabolism and T cell receptor and co-stimulatory signaling. According to some studies, PTEN may have the following characteristics.
PTEN may inhibit tumor cell growth by antagonizing protein tyrosine kinases, and may regulate tumor cell invasion and metastasis through interactions at focal adhesions. PTEN is frequently disrupted in a variety of sporadic tumors and is targeted by germline mutations in patients with cancer susceptibility syndromes. The mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation of noncoding RNAs, post-translational modifications, and protein-protein interactions, are altered in cancer.
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