Code | CSB-RA443117A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
FC | 1:50-1:200 |
The SIRPA recombinant monoclonal antibody synthesis starts with the extraction of SIRPA antibody genes from B cells that are isolated from immunoreactive rabbits. These genes undergo amplification and are cloned into suitable phage vectors, which are subsequently introduced into mammalian cell lines to facilitate the production of functional antibodies. The resulting SIRPA recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography. After rigorous verification, the antibody can be used in ELISA, IHC, and FC applications to detect the human SIRPA protein.
SIRPA is a protein that regulates immune responses and phagocytosis by interacting with CD47 and other ligands. Its main function is to prevent the unnecessary phagocytosis of healthy cells while facilitating the clearance of pathogens and damaged cells by immune cells. SIRPA's role in immune regulation has implications for both normal immune function and potential therapeutic strategies for cancer and other diseases.
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