SIRPB1 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA021335MA1HU
Size	US$210
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Image	The Binding Activity of Human SIRPB1 with Anti-SIRPB1 recombinant antibody Activity: Measured by its binding ability in a functional ELISA.Immobilized Human SIRPB1(CSB-MP021335HUd7) at 2 μg/mL can bind anti-SIRPB1 recombinant antibody.The EC50 is 0.9675-1.114 ng/mL. The Binding Activity of Human SIRPB1 with Anti-SIRPB1 recombinant antibody Activity: SIRPB1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SIRPB1(CSB-MP021335HUd7) with an affinity constant of 0.245 nM as detected by MetaSPR Assay (WeSPRTM 200).
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O00241

Target Names

SIRPB1

Alternative Names

Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b), SIRPB1

Species Reactivity

Human

Immunogen

Recombinant Human SIRPB1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

14H12

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, SPR

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:10000

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

Gene References into Functions

SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner. PMID: 25039969
SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. PMID: 19893026
SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration PMID: 16081415
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Detected in monocytes and dendritic cells.

Database Links

HGNC: 15928

OMIM: 603889

UniGene: Hs.664861

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Osteoclast differentiation Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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