Recombinant Rat Vascular cell adhesion protein 1(Vcam1)

Code CSB-CF025809RA(A4)
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Vcam1
Uniprot No. P29534
Alternative Names Vcam1; Vcam-1; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD antigen CD106
Species Rattus norvegicus (Rat)
Expression Region 25-739
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Gene References into Functions
  1. Western blotting analyses validated the fact that miR-142-5p inhibited the expression of VCAM-1 protein. Bone marrow-derived mesenchymal stem cells (BMMSCs) transfected with miR-142-5p showed a significantly decreased migration ability in a Transwell migration assay. PMID: 29789783
  2. Panax notoginseng saponins and Ginsenoside protect aorta form atherosclerosis via Rb1 via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. PMID: 27620662
  3. Berberine exhibited renoprotective effects in diabetic nephropathy (DN), and the underlying molecular mechanisms may be associated with changes in the levels and regulation of beta-arrestin 1/2 expression, as well as intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels in the kidney. PMID: 26531813
  4. The combination of DC vaccination and antiangionesis inhibited the rats with malignant glioma by stimulating immune response, supressing the expression of angiogenesis-related proteins VEGF, VCAM, and ICAM-1 PMID: 27072237
  5. VCAM1 was strikingly increased in neurons after intracerebral hemorrhage. PMID: 25868755
  6. Activation of Wnt/beta-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs. PMID: 26351298
  7. Adjuvant-induced arthritis was not associated with a change in VCAM1 levels. PMID: 25708190
  8. Expression of E-selectin and CAMs was also modified in an age- and ischemia/reperfusion-dependent manner. PMID: 25182537
  9. Upregulation of the adhesion molecules VCAM-1, ICAM-1, and E-selectin. PMID: 24289084
  10. It is reasonable to conclude that PDGFBB significantly enhanced the expression of VCAM-1 in BM-MSCs, which facilitated the migration of BM-MSCs towards PDGFBB. PMID: 24100802
  11. These findings suggested that glioma-induced change in VCAM-1 expression of bone marrow stem cells may play an important role in their tropism towards glioma. PMID: 22562815
  12. Pretreatment of LPS-stimulated vascular endothelial cells with berberine dose-dependently decreased the number of adhered leukocytes and VCAM-1 expression at both RNA and protein levels. PMID: 23058024
  13. results indicate that endothelin-1 stimulates arterial VCAM-1 expression through p38MAPK-dependent activation of neutral sphingomyelinases PMID: 22627111
  14. Clerodendron glandulosum.Coleb leaf extract attenuates in vitro macrophage differentiation and expression of VCAM-1 and P-selectin in thoracic aorta of atherogenic diet fed rats. PMID: 21961520
  15. A cholesterol diet does not play a role in the expression f VCAM-1 in the rat aorta. PMID: 22351665
  16. VCAM1 is expressed at different levels in the various organs of rats after anaphylactic shock. The change of VCAM-1 is the most obvious in lungs. PMID: 21604443
  17. Report specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation. PMID: 22195873
  18. black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expressions through blockage of NF-kappaB and JNK activation in intestinal epithelial cells PMID: 21184129
  19. The expression of ICAM-1 and VCAM-1 was significantly decreased in the kidney of spontaneously hypertensive rats treated with Cordceps Sinensis. PMID: 20197615
  20. Tanshinone IIA treatment leads to downregulation of ICAM-1 and VCAM-1 protein expression in brain microvascular endothelial cells. PMID: 20687137
  21. Isoflurane, sevoflurane and desflurane down-regulated the expression of VCAM-1 in a dose-dependent manner. PMID: 20936719
  22. Data indicates single-walled carbon nanotube exposure induces oxidative stress, thereby altering ICAM-1 and VCAM-1 expression. PMID: 21121367
  23. Puerarin inhibits the expression of VCAM and P-selectin in the aorta of diabetic rats. PMID: 18095572
  24. Fenofibrate can effectively prevent atherosclerosis by restoring NO concentration and down-regulating VCAM-1 expression. PMID: 18159007
  25. Gene expressions of LOX-1 and VCAM-1 were higher in the aortic arch of HIV-1transgenic rats (Tg); the level of sICAM-1 was elevated in the HIV-1Tg rats but the ICAM-1 gene expression profile did not show any differences. PMID: 19997643
  26. VCAM-1(+) immunoreactivity indicate an important role of choroid plexus in the induction of acute experimental autoimmune encephalomyelitis PMID: 19922364
  27. Integrin alpha2beta1 on rat myeloma cells modulates interaction of alpha4beta1 integrin with vascular cell adhesion molecule-1 but not fibronectin. PMID: 12160302
  28. During experimental allergic encephalomyelitis, a strong activation of spinal perivascular macrophages is observed accompanied by a consistently increased expression of VCAM-1. PMID: 12196270
  29. iNOS and VCAM-1 are induced by angiotensin II in a pathway that involves p38 MAPK PMID: 15001568
  30. Results are consistent with a role for the integrin alpha4beta1--vascular cell adhesion molecule-1 interaction in extension of sympathetic axons into the myocardium. PMID: 15366013
  31. Suppression of the expression levels of VCAM-1 is associated with the amelioration of chronic rejection by various drugs, suggesting that these molecules are important key molecules in chronic rejection. PMID: 15919506
  32. clusters of VCAM-1(+) immunoreactive cells localized in the choroid plexus epithelium and hypothalamo-hypophyses portal vessel system indicate an inflammation in acute autoimmune encephalitis PMID: 17064783
  33. These results suggest that P2Y2R activation in salivary gland cells increases the EGFR-dependent expression of VCAM-1 and the binding of lymphocytes. PMID: 17599409
  34. candidate genes for salt-sensitive hypertension in the SHRSP, including Edg1 and Vcam1, which are differentially expressed and lie on common and functionally important pathways. PMID: 17938382
  35. Thromboxane receptor upregulates IL-1beta-induced vascular cell adhesion molecule 1 (VCAM-1) expression by enhancing the activation of c-Jun N-terminal kinase (JNK) pathway PMID: 18032781
  36. the expression of VCAM-1 protein was upregulated in cerebral and common carotid arteries of simulated microgravity rats, and the upregulation of VCAM-1 may contribute to impaired endothelium-dependent relaxation in simulated microgravity rat vasculature PMID: 18221587
  37. VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery. PMID: 19958991

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Database Links

KEGG: rno:25361

STRING: 10116.ENSRNOP00000019377

UniGene: Rn.11267


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