Recombinant Human Lymphotoxin-alpha protein(LTA) (Active)

Code CSB-AP002171HU
Product Type Tumor Necrosis Factor
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P01374
Image
Storage Buffer 0.2 μm filtered PBS, pH7.4, with 0.02 % Tween-20 ,lyophilized
Alias LT-alpha, Tumor necrosis factor ligand superfamily member 1
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/ml, corresponding to a specific activity of >2.0x108 IU/mg in the presence of actinomycin D.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L
Research Area Signal Transduction
Source E.Coli
Gene Names LTA
Expression Region 35-205aa
Product Info Tag-Free
Mol. Weight 18.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 3555974; 3001109; 3536896; 6334807; 1353024; 8499947; 10202016; 14656967; 15489334; 1451807; 1733919; 8387891; 1670638; 1671667; 12746914; 17353895
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Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Involvement in disease Psoriatic arthritis (PSORAS)
Subcellular location Secreted, Membrane
Pathway NF-kappa B signaling pathway
TNF signaling pathway

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