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| Code | CSB-AP002171HU |
| Product Type | Tumor Necrosis Factor |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | P01374 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH7.4, with 0.02 % Tween-20 ,lyophilized |
| Alias | LT-alpha, Tumor necrosis factor ligand superfamily member 1 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/ml, corresponding to a specific activity of >2.0x108 IU/mg in the presence of actinomycin D. |
| Purity | >96% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L |
| Research Area | Signal Transduction |
| Source | E.coli |
| Gene Names | LTA |
| Expression Region | 35-205aa |
| Tag Info | Tag-Free |
| Mol. Weight | 18.7 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 3555974; 3001109; 3536896; 6334807; 1353024; 8499947; 10202016; 14656967; 15489334; 1451807; 1733919; 8387891; 1670638; 1671667; 12746914; 17353895 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Involvement in disease | Psoriatic arthritis (PSORAS) |
| Subcellular Location | Secreted, Membrane |
| Protein Families | Tumor necrosis factor family |
| Database Links |
HGNC: 6709 OMIM: 153440 KEGG: hsa:4049 STRING: 9606.ENSP00000403495 UniGene: Hs.36 |
| Pathway |
NF-kappa B signaling pathway
TNF signaling pathway |
LTA Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-RA013218A0HU | LTA Antibody | Human | ELISA |
LTA Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013218KA01HU | LTA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004313 | LTA Antibody | Human,Mouse,Rat,Monkey | WB,ELISA |
| CSB-PA863040 | LTA Antibody | Human | ELISA,IHC |
LTA Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP004941HU | Recombinant Human Lymphotoxin-alpha(LTA) | E.coli |
| CSB-YP013218HU CSB-EP013218HU CSB-BP013218HU CSB-MP013218HU |
Recombinant Human Lymphotoxin-alpha(LTA) | Yeast E.coli Baculovirus Mammalian cell |
LTA ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04743h | Human Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, cell culture supernates | 3.9 pg/mL |
Recombinant Human Keratin, type II cytoskeletal 6A(KRT6A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Mannan-binding lectin serine protease 1(MASP1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Microtubule-associated protein tau(Mapt)
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Human Thyroid peroxidase(TPO),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human C4b-binding protein alpha chain(C4BPA)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Keratin, type II cytoskeletal 1(KRT1)
Express system: E.coli
Species: Homo sapiens (Human)
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