Recombinant Human Lymphotoxin-alpha protein(LTA) (Active)

In Stock
Code CSB-AP002171HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P01374
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH7.4, with 0.02 % Tween-20 ,lyophilized
Alias LT-alpha, Tumor necrosis factor ligand superfamily member 1
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/ml, corresponding to a specific activity of >2.0x108 IU/mg in the presence of actinomycin D.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L
Research Area Signal Transduction
Source E.coli
Gene Names LTA
Expression Region 35-205aa
Tag Info Tag-Free
Mol. Weight 18.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 3555974; 3001109; 3536896; 6334807; 1353024; 8499947; 10202016; 14656967; 15489334; 1451807; 1733919; 8387891; 1670638; 1671667; 12746914; 17353895
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Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Involvement in disease Psoriatic arthritis (PSORAS)
Subcellular Location Secreted, Membrane
Protein Families Tumor necrosis factor family
Database Links

HGNC: 6709

OMIM: 153440

KEGG: hsa:4049

STRING: 9606.ENSP00000403495

UniGene: Hs.36

Pathway NF-kappa B signaling pathway
TNF signaling pathway

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