Recombinant Human Lymphotoxin-alpha protein(LTA) (Active)

1. The LTA were significantly increased in SZ patients, but no significant difference in the mRNA levels of LTA was observed between SZ patients and NC subjects. PMID: 28476335
2. There are independent and additive interactions between LTalpha +252 G/G genotype, chronic viral hepatitis, and habits of substance use on risk of hepatocellular carcinoma. PMID: 28738973
3. Independent and additive interaction between polymorphisms of TNFalpha -308 and lymphotoxin alpha +252 on risk of hepatocellular carcinoma related to hepatitis B has been reported. PMID: 28865603
4. The C allele for rs1042522 in p53 was genetically associated with a higher risk for RD but not for PVR in this cohort. This is the first association study attempting replication of PVR-associated risk alleles in a nonwhite population. PMID: 28106707
5. The results of this study showed that neither -252 G/A nor -804 C/A polymorphism of the LTA gene was found to be associated with overall stroke as well as any subtype of IS excluding SVD in North Indian population. PMID: 26707826
6. this study found an association between the single nucleotide polymorphism LTA +252 with the development of sepsis in Colombian patients PMID: 27592234
7. Fequencies of polymorphic allele and genotypes for the lymphotoxin-alpha gene, position +252 (rs909253), in Brazilian women with preeclampsia PMID: 26561241
8. The allelic frequencies of LTA SNPs were found to be significantly associated with the risk of oral cancer and precancerous lesions PMID: 27312561
9. rs909253 in LTA was identified to be significantly associated with ankylosing spondylitis susceptibility in this study population, but no significant association was found between ankylosing spondylitis risk and LTA rs2239704 or rs2229094 PMID: 28489756
10. study showed that heterozygous variant (AG) genotype of TNF-beta was associated with persistent primary immune thrombocytopenia, when compared with controls PMID: 26761582
11. a positive correlation of HLA-DRB1*12 and a negative correlation of HLA-DRB1*13 with younger patientsTNFb4 allele's negative association with older patients displaying higher PSA levels, higher GS and positive surrounding tissue involvement; positive association of TNFb5 allele for both older and younger patients PMID: 27102235
12. the present study suggests LTa +252G as a risk alleles for disease susceptibility associated with higher serum levels of LTa and concomitant discrete clinical features among Indian systemic lupus erythematosus patients in India PMID: 27838362
13. this study shows that TNF-b is elevated in wound exudates of patients with hidradenitis suppurativa PMID: 27819528
14. LTA -804C/A gene polymorphism is not found to be associated with the susceptibility of ischemic stroke in both Asian as well as in Caucasian population. PMID: 27411794
15. After multivariable analysis TNF-alpha polymorphism showed no consistent association with leukemia. CONCLUSIONS: This meta-analysis suggests that the LT-alpha +252 AA polymorphism is associated with the risk of leukemia PMID: 27647233
16. Tumor Necrosis Factor and Lymphotoxin in Regulation of Intestinal Inflammation. PMID: 27914457
17. joint effects of these CRP, TNF-alpha, and LTA risk alleles with physical inactivity in elders were observed, suggesting that physical activity may modulate effects of genotypes on handgrip strength. PMID: 27056089
18. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes PMID: 26821796
19. Polymorphism +252 LT gene did not show any significant association with COPD. PMID: 26932696
20. TNFB+252G/A was associated with presence of immune thrombocytopenia. PMID: 26076780
21. LTalpha plays a role in malignant angiogenesis and disease progression in Cutaneous T cell lymphoma and may serve as a therapeutic target in this disease. PMID: 25915535
22. LTA polymorphism is associated with genetic susceptibility of systemic lupus in Asians, but not in rheumatoid arthritis. PMID: 25931031
23. Studied the association between immuno-modulatory gene polymorphisms (including LTA) and risk for nasal NK/T-cell lymphoma in a Chinese population. Found The LTA +252 GA + AA genotypes were associated with increased risk for NK/T-cell lymphoma. PMID: 26108796
24. TNF-beta NcoI polymorphism, by itself, was not associated with increased stroke susceptibility. But the homozygous genotype for the allele TNFB2 was associated with higher expression of classical inflammatory and metabolic markers of stroke. PMID: 25063351
25. These results support an association between ANKK1 and LTA genetic markers and vulnerability to schizophrenia and show the potential influence of just one copy of the mutant C or G allele in the Egyptian population. PMID: 26114114
26. Studied six SNP loci: (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays. PMID: 26554163
27. TNF-alpha (-308G/A), TNF-beta (+252A/G) and IL-10 (-1082G/A, -819C/T and -592C/A) polymorphisms are associated with the susceptibility of oral lichen planus. PMID: 26221924
28. Elite controllers of HIV infection present marginal zone-like B-cell populations which IL-10 and LT-alpha expression profiles may favour homeostasis of immune responses and lymphoid microenvironments. PMID: 25003989
29. Biotin-pulldown assay showed that HuR specifically interacts with the 3'-untranslated region (3'-UTR) of the LTalpha mRNA PMID: 25980610
30. The AA genotype of LT-alpha + 252 was significantly associated with shortened overall or leukemia-free survival in patients with myelodysplastic syndrome with excess blasts. PMID: 23931336
31. MTHFR, TGFbeta1, and TNFB polymorphisms are not significantly associated with the risk of osteoporosis in rheumatoid arthritis. PMID: 25981594
32. statistical evidence for the interactions between 1) TNF/LTA SNP rs2229094 and depression symptoms for average pain intensity and duration and 2) IL1B two SNP diplotype and kinesiophobia for average shoulder pain intensity PMID: 24598699
33. The TNFB2/B2 genotype of TNF-beta NcoI polymorphism was associated with increased inflammatory and metabolic markers and this association was different according to sex of MS patients. PMID: 25173940
34. Review/Meta-analysis: Suggest lymphotoxin-alpha +252A/G gene polymorphism is a risk factor for NHL in North Americans, and this polymorphism may contribute to diffuse large B cell lymphoma susceptibility. PMID: 24610621
35. Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction PMID: 25735143
36. The findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF-beta region may modulate risk of migraine in the population of Asian ancestry. PMID: 24959879
37. Studies indicate that tumor necrosis factors TNF-alpha/TNF-beta and their receptor TNFR1 and TNFR2 play a regulatory role of different immune cells. PMID: 24896334
38. This indicates an association between polymorphism of the TNF-beta gene and post-operative sepsis, suggesting the TNFB2/B2 genotype as a high-risk factor for the development of sepsis after elective surgery. PMID: 24796628
39. IL-6-174 SNP is rare or not seen in the Han population in Guangzhou, so SNP at this locus cannot be selected for disease association analysis. PMID: 25140780
40. Our findings suggest that Hodgkin and Reed Sternberg cell-derived LTalpha is an important mediator that contributes to T cell recruitment into lesional lymph nodes in Hodgkin lymphoma. PMID: 25139349
41. TNFB2 allele was associated with the presence of multiple sclerosis independently of HLA-DRB1 in white patients and the TNFB2/B2 genotype was associated with increased TNF-alpha levels in white and brown patients. PMID: 24696164
42. TNFB +252A/G and exon 3 C/A polymorphisms are associated with vitiligo susceptibility PMID: 24312346
43. A significant association was detected between LT-alpha +249A/G and increased risk of diabetes, in particular for young-onset patients PMID: 24233435
44. TNF and LTA genetic polymorphisms contribute to SLE susceptibility in the Egyptian population and are associated with disease characteristics. PMID: 24420856
45. Polymorphisms of the LTA gene can probably be used with other genetic markers together to identify individuals at high susceptibility to myocardial infarction. PMID: 24642747
46. These results suggest for the first time that TNF-beta is involved in microenvironment inflammation in chondrocytes during rheumatoid arthritis PMID: 24283517
47. our meta-analyses suggested that the LTA rs1041981, rs2239704 and rs2229094 polymorphisms contributed to the increased risk of cancers. PMID: 24349304
48. This study provides evidence for rs1799724 at the LTA/TNFalpha locus as a susceptibility factor for idiopathic achalasia. PMID: 24259423
49. TNF-alpha -308 A/G and LT-alpha +252 A/G polymorphisms are associated with susceptibility to sarcoidosis in an European population.[META-ANALYSIS] PMID: 24197700
50. The TNF-beta gene A252G polymorphism might be a potential risk factor for the development of sarcoidosis. (Meta-analysis) PMID: 24244632
51. lymphotoxin alpha +252G>A polymorphism may influence susceptibility to T-cell lymphoma. PMID: 24035239
52. Our meta-analyses established a significant association of LTA rs909253 with cancer risk among multiple populations including North Americans, Asians, and Europeans. PMID: 24136744
53. Recipient TNFbeta gene polymorphisms may be useful in predicting pneumonia in kidney transplantation. PMID: 23953530
54. Single nucleotide polymorphism rs2239704 in the 5' UTR of the LTA gene was associated with increased risks of cervical cancer. PMID: 23824834
55. Greater concentrations of sCD40L and TNF-B at sites of stenosis suggest that these cytokines play a role in the pathogenesis of symptomatic SFA disease. PMID: 23299818
56. The B2B2 genotype of NcoI TNFbeta polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis. PMID: 23834030
57. single nucleotide polymorphisms in lymphotoxin alpha and TNF-alpha are not associated with migraine. PMID: 24054031
58. The results of the study strongly support a link between TNF-beta polymorphisms and vitiligo in Saudi patients. PMID: 23884763
59. The polymorphism of LTA rs1800683G>A contributes to non-Hodgkin's lymphoma prognosis. PMID: 23840460
60. lymphotoxin-alpha C804A polymorphism may have a role in decreasing mortality associated with statin treatment in patients with acute myocardial infarction PMID: 23398946
61. present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection PMID: 22748850
62. [review] Current findings in this review regarding epigenetic regulation of cytokine genes important in innate and adaptive immune responses focus on the TNF/lymphotoxin locus and T helper cell differentiation into Th1, Th2, and Th17 lineages. PMID: 23683942
63. Association between the lymphotoxin-alpha gene polymorphism and chagasic cardiopathy. PMID: 23289732
64. The frequency of the single-base change polymorphic variants identified in lymphotoxin alpha (LTA) (+252 G/A) in patients with type 2 diabetes was investigated PMID: 23550407
65. TNF-beta +252 A>G polymorphism is positively associated with susceptibility to cancer. However, this study also suggests that more studies should be conducted to further confirm the associations between this variant and specific types of cancers. PMID: 23377953
66. Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata. PMID: 22897480
67. Studies indicate roles for Lymphotoxin-alpha (LTalpha) and lymphotoxin-beta receptor (LTbetaR) pathway in innate and adaptive immune responses to microorganisms. PMID: 23524463
68. This meta-analysis suggested that the 252A/G polymorphism in the lymphotoxin-alpha gene is a risk factor for asthma in adults and atopic populations. [meta-analysis] PMID: 22882567
69. The high affinity associated with LT-(TNFR1)1 is due to the interaction between the CRD4 domain with LT. PMID: 22568977
70. OR revealed statistically significant risk for CHD with respect to IFN-gamma +874 T allele, whereas OR for TNF-beta +252 A/G showed three fold risk in homozygous condition though not significant. No such trend could be observed for TNF-alpha -308 G/A polymorphism. PMID: 23159874
71. the present study did not support a role for the tested LTA variants in migraine, investigation of other variants within the LTA gene is still warranted. PMID: 23051989
72. Lymphotoxin-alpha 252A>G polymorphism is not associated with breast cancer. PMID: 22901152
73. No lymphotoxin-alpha SNP association was found with respect to sepsis susceptibility. PMID: 22507624
74. Data indicate that the biologic activity of pateclizumab on the lymphotoxin alpha (LTalpha) pathway. PMID: 22225620
75. Results do not support a major role of LTA gene polymorphism at position 252 in the susceptibility to systemic lupus erythematosus in Portuguese Caucasian patients. PMID: 21544635
76. single nucleotide polymorphisms within the PTGS2 and LTA inflammatory markers were associated with pain and quality of life in a large sample of long term lung cancer survivors PMID: 22464751
77. In vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease. PMID: 22427961
78. Lymphotoxin alpha +252A/G polymorphism was not associated with visceral leishamaniasis. PMID: 22311026
79. In this study, the significantly higher frequency of the TNF-beta NcoI A/A genotype and the local TNF expression indicate that the pro-inflammatory cytokine TNF plays a role in the development of Barrett's Esophagus and Esophageal adenocarcinoma. PMID: 22243485
80. The contribution of polymorphisms, such as MAOA T941G, MTHFR C677T, and TNF-beta G252A, were more important than personality traits in the pathogenesis of migraine, a multifactorial disorder. PMID: 22193458
81. A strong association was found between several single nucleotide polymorphisms in the LTA/LTB/TNFalpha locus and Sjogren syndrome. PMID: 22294627
82. TNFalpha/LTalpha high-producer haplotypes were significantly higher in Non Hodgkin lymphoma patients and conferred increased risk of non-Hodgkin lymphoma. PMID: 22177457
83. Single-nucleotide polymorphisms in LTA is associated with chronic kidney disease in Type 2 diabetes. PMID: 21765051
84. LTA +252G allele is associated with increased risk for the presence of gastric cancer in a Helicobacter pylori infection positive subgroup. PMID: 21793721
85. Comparative analysis by group did not show a significant difference in the frequency of the alleles and genotypes between KD with CA vs. KD without CA vs. controls, for both TNF -308 and LTA +252 PMID: 22100609
86. No overall association was seen between TNFbeta gene variants and migraine. PMID: 22001640
87. The lymphotoxin-alpha 252 A>G polymorphism highlights a possible common genetic predisposition to rheumatoid arthritis and dyslipidemia. PMID: 21459939
88. A haplotype-based association of four lymphotoxin-alpha gene polymorphisms is found with the risk of coronary artery disease in Han Chinese. PMID: 21628868
89. The NFB +252A>G polymorphism was not (p = 0.6) associated with risk of asthma in the children in Egyptian population. PMID: 21271873
90. The LTA +252 A/G polymorphism is associated with both susceptibility to and mortality from sepsis. PMID: 21366408
91. TNF-beta SNPs did not appear to be a contributing factor influencing the morbidity of the patients with acute respiratory distress syndrome after operation for esophageal carcinoma. PMID: 19958618
92. TNF-beta +252GG genotype was found more frequent in Turkish breast cancer patients than controls. PMID: 21323572
93. These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD. PMID: 20548340
94. TNF-alpha and -beta polymorphisms are strongly associated with breast cancer in the Dravidian but not in the Indo-European group PMID: 20878356
95. Genetic polymorphisms of tumor necrosis factor-alpha and lymphotoxin-alpha in Chinese patients with non-Hodgkin lymphoma. PMID: 20957367
96. Lymphotoxin-alpha polymorphism may be associated with ankylosing apondylitis in Ningxia population. PMID: 21482522
97. The allele TNF beta*1 of the TNF gene is overrepresented in Polish patients with Lofgren syndrome. PMID: 21319595
98. The present data show a difference in the association of variations in ALR2, iNOS and TNFB genes with diabgetic retinopathy, when compared to our previous reports. PMID: 21067489
99. The strong association found in the rs2229094(T-->C) of the LTA gene may indicate an important role of this polymorphism in the development of proliferative vitreoretinopathy (PVR) PMID: 20663564
100. A allele of TNF-alpha (-308) and TNF-ss (+252) was associated with a 1.76-fold increased risk of DCM compared with G allele (OR PMID: 20491592

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HGNC: 6709

OMIM: 153440

KEGG: hsa:4049

STRING: 9606.ENSP00000403495

UniGene: Hs.36