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Researchers find a way to diminish leukemic stem cells
Researchers find a way to diminish leukemic stem cellsChronic myelogenous (or myeloid or myelocytic) leukemia (CML) is a type of cancer that occurs when too many myeloid cells are made in the bone marrow. CML originates from a rare population of cells, known as leukemic ste...
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Human monoclonal antibody against Dengue fights Zika in mice
Human monoclonal antibody against Dengue fights Zika in miceA team composed of researchers from Washington University School of Medicine in the USA and Imperial College in the UK has identified an anti-Dengue virus antibody that has therapeutic activity against Zika virus. ...
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Structural study reveals three-dimensional properties of a mutated breast cancer protein
Structural study reveals three-dimensional properties of a mutated breast cancer proteinBRCA1 is a tumor suppressor gene that encodes a protein called breast cancer type 1 susceptibility protein. Under normal conditions, BRCA1 takes part in DNA double-strand break repair and mismatch repair, decreasing the ...
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Study points to a new strategy for treating osteoporosis
Study points to a new strategy for treating osteoporosisA study by Zhejiang University researchers and collaborators at the University of Alabama at Birmingham could yield new treatment strategies for patients with age-associated osteoporosis. Osteoporosis is a b...
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Neuroligin-3 represents a potential therapeutic target for glioma
Neuroligin-3 represents a potential therapeutic target for gliomaAccording to a study published online 20 September 2017 in Nature, blocking the neuroligin-3 protein inhibits the growth of high-grade gliomas. The study provides a novel way to treat high-grade gliomas, the leading caus...
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Exosomes carrying microRNAs regulate insulin sensitivity
Exosomes carrying microRNAs regulate insulin sensitivityFindings of a new study appearing in the journal Cell add to the growing body of evidence that exosomes carrying microRNAs (miRNAs) play a key role in insulin resistance in diabetes. The study, led by resear...
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Inhibition of IGPR-1 represents a novel way to treat colon cancer
Inhibition of IGPR-1 represents a novel way to treat colon cancerResearchers have found a new way to inhibit the growth of colon cancer and enhance the efficacy of existing chemotherapy drugs. The study (Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer gr...
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Research reveals a role of CIC gene in cancer
Research reveals a role of CIC gene in cancerScientists at Centro Nacional de Investigaciones Oncológicas (CNIO) have demonstrated that inactivation of the CIC gene in adult mice triggers the formation of T-ALL, an aggressive form of blood cancer. CIC...
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New gene implicated in an inherited kidney disorder
New gene implicated in an inherited kidney disorderA research team has made progress in understanding the genetic basis of renal agenesis (RA), an inherited disorder characterized by the absence of one or both kidneys. The team is composed of researchers fro...
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New strategy to tackle obesity
New strategy to tackle obesityScientists at Washington University School of Medicine have found a way to turn bad fat into good fat. The discovery would lead to new preventive strategies for overweight, obesity, and related disorders like diabetes. ...
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Study sheds light on how α-syn triggers neurotoxicity in Parkinson's disease
Study sheds light on how α-syn triggers neurotoxicity in Parkinson's diseaseAlpha-synuclein (α-syn) is a protein highly expressed in the central nervous system. Parkinson's disease (PD) and several other neurodegenerative disorders involve the accumulation of α-syn in neurons in the brain. A l...
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Two cytokines involved in progressive multiple sclerosis
Two cytokines involved in progressive multiple sclerosisMultiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. The debilitating disease can cause disability. Worldwide, there are an estimated 2.3 million people affected by i...
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Resistance to gemcitabine is linked to bacteria
Resistance to gemcitabine is linked to bacteriaResearchers from the Weizmann Institute of Science have found a new mechanism of tumor resistance to chemotherapy. The study adds to the growing body of evidence that microorganisms have an impact on the effectiveness of...
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The mystery of aging
The mystery of agingLongevity is a common pursuit of humans. Various factors affect an individual's life expectancy such as gender, genetics, access to health care, diet, and physical exercise. Due to advances in science, average human life...
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New treatment for obstructive lung disease
New treatment for obstructive lung diseaseAccording to a paper appearing in the New England Journal of Medicine, an antibody therapy approved for the treatment of asthma -- mepolizumab -- can treat eosinophilic chronic obstructive pulmonary disease (COPD). ...
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Tofacitinib shows promise in curbing chronic itch
Tofacitinib shows promise in curbing chronic itchChronic itch is a common condition that affects millions of people, but its causes are poorly understood. Now, researchers from Washington University School of Medicine, University of Cincinnati College of Medicine, and ...
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Novel antibody detection strategy may improve diagnosis of type 1 diabetes
Novel antibody detection strategy may improve diagnosis of type 1 diabetesA team of researchers from Stanford University, Johns Hopkins School of Medicine, University of Florida, and South University of Science and Technology of China, has developed a novel antibody detection strategy that wou...
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Cigarette smoke induces epigenetic changes that might contribute to lung cancer
Cigarette smoke induces epigenetic changes that might contribute to lung cancerCigarette smoke is hazardous to health. One adverse effect of cigarette smoke is the increased risk of various cancers, especially lung cancer. Smokers account for 85% of all lung cancer cases. Harmful substances in ciga...
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