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Lowering acrolein inhibits progression of Parkinson's disease in rats
Lowering acrolein inhibits progression of Parkinson's disease in ratsResearchers from Purdue University have implicated a molecule called acrolein in the pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease (AD), which affect...
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Vitamin D deficiency might confer risk of diabetes
Vitamin D deficiency might confer risk of diabetesOur bodies need many important nutrients to function properly. Vitamin D is one of such nutrients. Vitamin D can be synthesized in the body in response to sun exposure. So it is not an essential dietary factor. ...
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Study provides insights into amplification of the genetic risk for rheumatoid arthritis upon exposure to environmental pollutants
Study provides insights into amplification of the genetic risk for rheumatoid arthritis upon exposure to environmental pollutantsA new study now sheds light on why exposure to environmental pollutants can amplify the genetic risk for rheumatoid arthritis (RA), the most common type of autoimmune arthritis. Published ahead of print Apri...
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How does HIV evade anti-viral immunity?
How does HIV evade anti-viral immunity? Researchers from Trinity College Dublin in Ireland and University of Oxford in the United Kingdom have identified a mechanism by which HIV evades anti-viral immune responses. Viral illnesses can be hard to d...
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Research suggests a protective role of large SOD1 fibrils in ALS
Research suggests a protective role of large SOD1 fibrils in ALSOn 14 March 2018, the world-famous theoretical physicist, cosmologist, author, and director of research, Stephen William Hawking, died after decades of struggling with amyotrophic lateral sclerosis (ALS), an incurable di...
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EB3 protein: a promising therapeutic target against HCMV infection
EB3 protein: a promising therapeutic target against HCMV infectionA new study now deepens our understanding of how an extremely common human virus establishes its infection and provides novel targets for anti-viral therapies. Human cytomegalovirus (HCMV), also referred to ...
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Scientists identify intestinal target cell of norovirus
Scientists identify intestinal target cell of norovirusA study, carried out by researchers from Washington University School of Medicine, the University of Illinois at Chicago College of Medicine, Harvard T. H. Chan School of Public Health, New York University School of Medi...
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A study demonstrates the efficacy of a peptide drug in AML
A study demonstrates the efficacy of a peptide drug in AMLA study, led by researchers from Albert Einstein College of Medicine and Aileron Therapeutics, has demonstrated the therapeutic potential of an investigational drug called ALRN-6924 in the life-threatening cancer acute m...
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FOXF1 protein suppresses pulmonary fibrosis
FOXF1 protein suppresses pulmonary fibrosisThe FOXF1 gene suppresses pulmonary fibrosis (scarring of the lungs), according to a study by researchers from the Perinatal Institute of Cincinnati Children's Hospital Research Foundation. Therefore, FOXF1 and related p...
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Toxicity of apolipoprotein E4 could be ameliorated
Toxicity of apolipoprotein E4 could be amelioratedA new study, led by researchers from the University of California and Gladstone Institute of Neurological Disease, has now shed light on the toxicity of apolipoprotein E4 in human neurons. Genes are one of m...
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Novel host-modulating therapy for bacterial pneumonia
Novel host-modulating therapy for bacterial pneumoniaDr. Hongbo Luo, a researcher at Harvard Medical School and Children's Hospital Boston, and co-workers have recently found a novel, effective way to treat bacterial pneumonia. Bacterial pneumonia is an inflam...
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Novel combination therapy effectively treats non-small cell lung cancer
Novel combination therapy effectively treats non-small cell lung cancerA combination of the immunotherapy nivolumab and the immunostimulatory agent ALT-803 may be an effective regimen for metastatic non-small cell lung cancer, according to a recent clinical trial. The research was carrie...
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A parasite-derived protein may treat bladder disease induced by chemotherapy
A parasite-derived protein may treat bladder disease induced by chemotherapyCarried out by researchers from Biomedical Research Institute, Stanford University School of Medicine, OneOme, King Abdulaziz City for Science and Technology, and the University of Nottingham, a new study demonstrates th...
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SAMHD1 could be targeted to control HIV infection and cancer
SAMHD1 could be targeted to control HIV infection and cancerSAMHD1, a cellular enzyme that blocks replication of HIV in host cells, is known to inhibit retroviral infection. But the role of SAMHD1 in the regulation of antiviral innate immune responses has not been well defined. A...
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Red-meat free diets correlate with lower risks of distal colon cancer in women
Red-meat free diets correlate with lower risks of distal colon cancer in womenSix researchers from the University of Leeds (Leeds for short) in the United Kingdom, including Diego Rada‐Fernandez de Jauregui, Charlotte E.L. Evans, Petra Jones, Darren C. Greenwood, Neil Hancock, and Janet E. Cade,...
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Upfront tumor sequencing improves diagnosis of Lynch syndrome
Upfront tumor sequencing improves diagnosis of Lynch syndromeColorectal cancer, one of the most frequently diagnosed cancer, is a big killer among both men and women. Lynch syndrome is the most common hereditary form of colorectal cancer, accounting for about 3% of all colorectal ...
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Itaconate is a negative regulator of inflammation
Itaconate is a negative regulator of inflammationA new study suggests that a glucose metabolite called itaconate functions as a negative regulator of macrophages (a type of immune cells). Macrophages can cause inflammation. This study reveals that itaconate is critical...
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LZK gene regulates the repair of brain injury
LZK gene regulates the repair of brain injuryAstrocytes are a type of star-shaped glial cells found in the brain and spinal cord. These cells possess multiple functions both in health and disease. Recently, biological researchers have found that switching on a spec...
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