A small but important guy--miRNA
A small but important guy--miRNAIn 1989, Victor Ambros discovered that the gene lin-4 controls the development of C. elegans larvae by inhibiting the lin-14 gene. However, he thought the gene lin-4 expressed a regulatory protein that inhibited the expr...
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Prostate cancer cells release a protein that promotes self-growth
Prostate cancer cells release a protein that promotes self-growthRecently, a study called 'Membrane insertion and secretion of Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma' has been published in the Scientific Reports. The...
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A protein can provide clues for the treatment of graft versus host disease
A protein can provide clues for the treatment of graft versus host diseaseWhen an immunodeficient person receives an implant containing immunocompetent cells (bone marrow, thymus, etc.), it usually causes immunological damage to the cells in this person but not the graft. This phenomenon is ca...
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Why are you drunk?
Why are you drunk?Wine is an essential drink for gatherings or feasts, but some people fall for a cup, and some people are not drunk for a thousand cups. Andre the Giant, a Frenchman, his record was to drink 120 to 150 bottles of beer...
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Discovery of therapeutic targets for melanoma
Discovery of therapeutic targets for melanomaA study led by a professor of dermatology at Boston University School of Medicine Herbert Mescon has shown that they have identified a biomarker and a possible new treatment for melanoma. These findings were published in...
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Proteins associated with cancer growth can promote fatal lung disease
Proteins associated with cancer growth can promote fatal lung diseaseIdiopathic pulmonary fibrosis (IPF) is a disease with unknown causes, which causes lung scarring and stiffness. As time goes by, scars will worsen and stiffness will make breathing more difficult. Ultimately, the lungs m...
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Immunotherapy to treat cancer
Immunotherapy to treat cancerCancer is the second leading cause of death in the world, with an estimated 9.6 million people worldwide dying of cancer in 2018. Globally, about one in six deaths are due to cancer. The number of people who die from c...
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A newly found mouse model for the research of human gastric cancer
A newly found mouse model for the research of human gastric cancerMice play an important role in cancer research, but like all other animal models of human disease, mice have their limitations. Especially for gastric cancer, mice have always been considered to be poor subjects because ...
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Brain stem cells age faster in patients with multiple sclerosis
Brain stem cells age faster in patients with multiple sclerosisA study led by UConn Health has shown that the brain stem cells of the most severe multiple sclerosis patients appear to be much older than the actual age. Premature aging cells have a different role in the brain than no...
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Epidemic Dengue Fever in Southeast Asia
Epidemic Dengue Fever in Southeast AsiaWhat is the number one killer in the world? Is this a war? Is it a traffic accident? Or is it a tsunami? No, these are not! It is a disease, especially a plague, which has claimed many lives. A plague in history caused n...
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Discovery of potential new markers of invasive prostate cancer
Discovery of potential new markers of invasive prostate cancerThe prostate is a sexual secretory gland with both internal and external secretory functions, located between the bladder and the urogenital ridge. The prostate secretes prostatic fluid, which is the main component of se...
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The balance of two enzymes is related to pancreatic cancer survival
The balance of two enzymes is related to pancreatic cancer survivalThe pancreas is deep in our upper abdomen, which is an inconspicuous organ. Although it is small, it is very important to human. The pancreas produces digestive enzymes that help digest foods especially fats, and it also...
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Precisely targeted liposomes inhibit the metastasis of triple-negative breast cancer in mice
Precisely targeted liposomes inhibit the metastasis of triple-negative breast cancer in miceResearchers at the Boston Children's Hospital teamed up with bioengineers at the City College of New York (CCNY), found in a mouse model of triple-negative breast cancer, dual targets with existing chemotherapy drugs tar...
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Cordycepin may provide new therapies for osteoarthritis
Cordycepin may provide new therapies for osteoarthritisA new study suggests that a substance in a fungus that infects caterpillars can provide new therapeutic hopes for patients with osteoarthritis. In 1951, Cunningham of Germany purified in Cordyceps militaris ...
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Why do some brain tumors response to immunotherapy?
Why do some brain tumors response to immunotherapy? Glioblastoma is a malignant and invasive brain tumor. Patients usually have surgical removal of the tumor as much as possible, followed by radiation and chemotherapy. However, the prognosis of glioblastoma is very severe...
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Immunotherapy can effectively treat patients with recurrent glioblastoma
Immunotherapy can effectively treat patients with recurrent glioblastomaIn recent years, immunotherapy has become increasingly popular in the treatment of cancer, a method of killing cancer cells using the body's own immune system. Among them, immunotherapeutics have been shown to be helpful...
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The discovery of mitochondrial to nuclear messenger protein
The discovery of mitochondrial to nuclear messenger proteinResearchers have identified a protein, G-protein pathway inhibitor 2, also known as GPS2, which moves from the mitochondria of cells to the nucleus in response to stress and fat cell differentiation. Although proteins wi...
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Enzyme USP15 regulates DNA homologous recombination repair and cancer cells response to PARP inhibitors
Enzyme USP15 regulates DNA homologous recombination repair and cancer cells response to PARP inhibitorsResearchers at George Washington University's (GW) cancer center have found that the enzyme USP15 may lead to new treatments for breast and pancreatic cancer. Their findings are published in Nature Communications. ...
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Skin repair may eliminate chronic diseases associated with inflammatory aging
Skin repair may eliminate chronic diseases associated with inflammatory agingThe skin covers the whole body and is the largest organ of the human body. It mainly plays the role of protecting the body, perspiration, feeling cold and heat. The skin has two barrier functions: on the one hand, it pre...
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Lack of key proteins may lead to rapid and severe bone loss
Lack of key proteins may lead to rapid and severe bone lossA study published in the Journal of Dental Research has indicated that the lack of proteins essential for controlling inflammation could lead to rapid and severe bone loss. This is the first study to test the effect of t...
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An existing drug has been found to be potential molecular prosthesis for lacking lung protein in cystic fibrosis therapy
An existing drug has been found to be potential molecular prosthesis for lacking lung protein in cystic fibrosis therapyCystic fibrosis (CF) is a common genetic disorder. It is mainly characterized by dysfunction of endocrine and exocrine glands, hyperplasia of mucous glands, thick secretion, and elevated sodium chloride content in sweat....
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Researchers have developed a new molecule that can stop the progression of heart failure
Researchers have developed a new molecule that can stop the progression of heart failureHeart failure occurs when the heart is unable to pump enough blood and oxygen to support the body's other organs due to its systolic and (or) diastolic functions are impaired. Heart failure is a serious disease. But it d...
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An enzyme has been found to play a key role in the proliferation and resistance to therapies of breast cancer
An enzyme has been found to play a key role in the proliferation and resistance to therapies of breast cancerBasal-like breast cancer, short for BLBC, is a subtype of triple negative breast cancer (TNBC), which is the most malignant and aggressive type in breast cancer. Most studies currently support that the typical BLBC immun...
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A pregnant protein could treat geriatric diseases
A pregnant protein could treat geriatric diseasesRecent research conducted by Dr. Amy Wyatt from Flinders University in South Australia has shown that a protein occurred during pregnancy could prevent and treat a series of diseases associated with age, such as Alzheime...
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How does celastrol make the brain sensitive to leptin?
How does celastrol make the brain sensitive to leptin?Although medicine has been improving, no effective drugs for treating obesity have been found. The discovery of leptin 20 years ago brought hope to the treatment of obesity. Leptin acts on the metabolism-regulating cente...
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A protein could be a boimaker in the blood test for early-stage liver disease
A protein could be a boimaker in the blood test for early-stage liver disease Nonalcoholic fatty liver disease (NAFLD) is a condition that affects the liver in the people who do not drink or consume a little alcohol. As the name suggests, NAFLD is characterized by excess storage of fat in liver ce...
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Preventing brain tumors from repairing themselves by blocking a protein
Preventing brain tumors from repairing themselves by blocking a proteinGlioblastoma multiform (GBM) is a rare and highly invasive brain tumor. The tumor is located under the cortex and grows infiltrated. It often attacks several lobes and deep structures and can spread to the contralateral ...
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Trapping pathological proteins that cause many neurodegenerative disorders
Trapping pathological proteins that cause many neurodegenerative disordersTDP-43, short for trans-activation response DNA-binding protein 43, is a versatile DNA and RNA binding protein that functions in intracellular RNA transcription, alternative splicing, and regulation of mRNA stability. RN...
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The possible role for FOXP1 protein in the control of autoimmune diseases has been identified
The possible role for FOXP1 protein in the control of autoimmune diseases has been identifiedResearchers at the Russian Academy of Sciences' Institute of Bioorganic Chemistry (IBCh RAS) and Memorial Sloan Kettering Cancer Center have created a genetic model to help understand how the body inhibits autoimmune and...
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Inhibiting oncogenic proteins can prevent scleroderma fibrosis
Inhibiting oncogenic proteins can prevent scleroderma fibrosisScleroderma is an autoimmune disease of connective tissue, which is characterized by hard and thickened skin, spontaneous scabs, and sometimes in other organs of the body. And it may also cause vascular disease and varyi...
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Researchers have discovered the mechanism of how diabetes causes muscle loss
Researchers have discovered the mechanism of how diabetes causes muscle lossDiabetes is a metabolic disease characterized by hyperglycemia. Due to long-lasting hyperglycemia, diabetes causes chronic damage and dysfunction to various tissues, especially eyes, kidney, heart, blood vessels and nerv...
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A novel checkpoint protein provides a new strategy for cancer immune therapy
A novel checkpoint protein provides a new strategy for cancer immune therapyA study published in the journal Cell characterized a new checkpoint protein on the immune system cells is active in tumors. And the researchers from an international team of Vanderbilt successfully blocked it in combina...
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How do blood vessels protect the brain during inflammation?
How do blood vessels protect the brain during inflammation?Recently, researchers at the University of British Columbia have found how blood vessels protect the brain during inflammation. This finding may lead to new treatments for neurodegenrative diseases such as stroke, multip...
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Can a nerve injury induce amyotrophic lateral sclerosis?
Can a nerve injury induce amyotrophic lateral sclerosis?What is amyotrophic lateral sclerosis?Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Motor neu...
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Gene therapy can durably reverse congenital deafness in mice
Gene therapy can durably reverse congenital deafness in miceCongenital deafness is deafness that is already present after birth and is classified into hereditary and non-hereditary. Nonsyndromic in hereditary deafness accounts for about 80%. Most patients with non-syndromic conge...
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Discover new deadly factors against melanoma in mice
Discover new deadly factors against melanoma in miceMelanoma is a common skin tumor caused by abnormal hyperplasia of melanocytes, which is extremely malignant and accounts for a large part of skin tumor deaths. It occurs mostly on the skin or near the mucous membrane of ...
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Discovery of a protein that causes racial differences in prostate cancer
Discovery of a protein that causes racial differences in prostate cancer The prostate is a male-specific gonad. The prostate is as big as a chestnut, with its bottom facing up to the bladder and the sharp point pointing downwards to the urogenital ridge. It secretes prostatic fluid, which is ...
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The core of Alzheimer's disease is
The core of Alzheimer's disease is "lack of cleanness" in the brain cellsAs all we know, Alzheimer's disease (AD) is the common neurodegenerative disease, which is mainly characterized by failure of memory. And there has been no cure for AD so far. It is one of the global health concerns. The...
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How do neuroactive steroids suppress inflammatory signals in the immune system and brain?
How do neuroactive steroids suppress inflammatory signals in the immune system and brain?A study published in Nature Scientific Reports, in collaboration with UNC medical school and the University of Maryland, have shown how the neurosteroid allopregnanolone blocks the activation of pro-inflammatory proteins...
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How does sleep affect cardiovascular diseases?
How does sleep affect cardiovascular diseases?About one-third of one's lifespan is spent on sleep. When we sleep, our brain and body can get rest, recuperation and recovery. However, when our sleep is not enough or we suffer from sleep disorders, various diseases wi...
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The unexpected discovery about rheumatoid arthritis offers a novel therapy for joint inflammation
The unexpected discovery about rheumatoid arthritis offers a novel therapy for joint inflammationRheumatoid arthritis (RA) is an autoimmune disease in which the body's immune system mistakenly attacks the joints. The immune system normally protects its health by attacking foreign substances like bacteria and viruses...
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The proteins released by fat after exercise can improve glucose
The proteins released by fat after exercise can improve glucose As we all know, exercise make us stronger and healthier. But do you learn how exercise helps us healthy on a molecular level?  Researchers at Joslin Diabetes Center answered the question in a study that...
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The protein YTHDF1 enhances the anti-tumor response
The protein YTHDF1 enhances the anti-tumor responseOne reason that cancer cells can thrive is that they are able to escape from your immune system. Immunotherapy is a type of biological therapy that helps your immune system fight cancer. The immune system plays an import...
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APOE protein has been found to be a central regulator
APOE protein has been found to be a central regulator Apolipoprotein E is abbreviated APOE. APOE is a type of lipoprotein (a protein connected to a fat). Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are ...
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FGL2 protein -- a potentially effective target for glioblastoma
FGL2 protein -- a potentially effective target for glioblastomaResearchers at the University of Texas MD Anderson Cancer Center have found an immune regulator that seems to modulate the progression of glioblastoma by switching off immune surveillance. It predicted an underlying new ...
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What you eat could affect your brain and memory
What you eat could affect your brain and memoryAs the saying goes, ''you are what you eat''. It implies that a person's psychological, emotional, and physical health is determined by the food the person eats. Good food can shape the body and character, and instead, b...
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Discovery on defective
Discovery on defective "brakes" that interferes with myocardial contraction and relaxation Hypertrophic cardiomyopathy, also known as HCM, is the most common genetic cardiac disease in which the heart muscle in the ventricles becomes thickened without any obvious cause. It is caused by one or more gene mutatio...
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A study reveals the Cdk5 gene causes the differences between female and male mice in fear   memory
A study reveals the Cdk5 gene causes the differences between female and male mice in fear memoryFear is an emotional experience generated by a huge psychological shock or threat, which is a negative emotion. It is a double-edged sword. It is both protective and destructive. Fear endows humans with the ability to ad...
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A protein has been found to promote small artery grow to the damaged heart tissue in mice
A protein has been found to promote small artery grow to the damaged heart tissue in miceHeart disease, the main cause of heart attacks, is the world's biggest killer. In 2015, an estimated 17.3 million people died from heart disease and the number is expected to exceed 23.6 million by 2030. Recent...
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Multiple sclerosis-helping cells to repair themselves
Multiple sclerosis-helping cells to repair themselvesMultiple sclerosis, also known as MS, is a potentially disabling disease that affects the brain and spinal cord. Around 400,000 people are living with MS in the United States and approximately 2.1 million individuals hav...
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