Novel gene targets for cancer metastasis
Novel gene targets for cancer metastasisCancer has always been a hot spot in the field of medical research. What makes cancer so difficult to treat? Cancer metastasis, which refers to the movement of cancer cells from their original location to other parts of ...
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Stress may result in autoimmune diseases
Stress may result in autoimmune diseasesA large body of evidence supports the influence of stress on human health. In a novel study described in the Journal of the American Medical Association, researchers headed by Dr. Huan Song of the University of Iceland r...
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Inhibition of AMPK might be a strategy for treating deadly brain cancer
Inhibition of AMPK might be a strategy for treating deadly brain cancerAMPK, an enzyme thought to be a tumor suppressor, may actually promote brain tumor growth. This is the discovery of a new study (AMP kinase promotes glioblastoma bioenergetics and tumor growth) published this week in the...
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Women staying up late may be at elevated risk of depression
Women staying up late may be at elevated risk of depressionThe health benefits of going to bed early at night and rising early in morning are emphasized now and then. Now a new study provides further evidence for this. Published in the Journal of Psychiatric Research, a study...
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Who are vulnerable to the flu?
Who are vulnerable to the flu?Influenza, more commonly known as the flu, is an extremely widespread disease that is caused by the flu virus. Populations with weakened immune systems, including children and the elderly, are vulnerable to the flu, part...
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Bacterial composition in the vagina may influence the risk of cervical cancer
Bacterial composition in the vagina may influence the risk of cervical cancerIt has been known for a while that long-term infection with HPV, especially with high-risk strains, may increase a woman's chance of developing cervical cancer, the second most common female-specific cancer after breast ...
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Does hunger make you angry?
Does hunger make you angry?Do you know the meaning of the word 'hangry'? It's blameless if you don't know because it was only recently that the Oxford Dictionary included this word. This word is a combination of two words, 'hunger' and 'anger', an...
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Zileuton improves tauopathy in mice
Zileuton improves tauopathy in miceInsufficient knowledge of mechanisms underlying dementia has hindered the development of effective therapies. A recent study provides new clues to the disease and may inform new treatments. The study, carried out by Temp...
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Study brings hope for patients with solid tumors
Study brings hope for patients with solid tumorsOur bodies have an immune system to prevent or fight against illnesses and infections. The immune system is critical for us to keep health. Individuals with a weakened immune system are more susceptible to illnesses and ...
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A natural antibody prevents atherosclerosis in mice
A natural antibody prevents atherosclerosis in micePhospholipids, which are a class of lipids, are the primary building blocks of cellular membranes and membranes surrounding organelles. They possess multiple functions, such as forming permeability barrier, providing a s...
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Type 1 diabetes leads to cognitive decline in the long-term
Type 1 diabetes leads to cognitive decline in the long-termDiabetes, cancer, autoimmune diseases, and many other complex conditions have increasingly become the focus of attention. Some diseases are referred to as 'complex conditions' because their etiology involves various fact...
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The culprit of brain tumor identified
The culprit of brain tumor identifiedA research study has identified the culprit of the most frequent primary brain tumor, glioblastoma multiforme. Carried out by researchers from Virginia Commonwealth University (VCU) and the University of California, the ...
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People with monogenic obesity would benefit from an appetite-controlling drug
People with monogenic obesity would benefit from an appetite-controlling drugAt a very young age, some people already become overweight or obese. In addition to lifestyle factors such as high-calorie diets and lack of physical activities, an individual’s genetic makeup also affects the risk of ...
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A mechanism by which APOE4 confers risk to Alzheimer's
A mechanism by which APOE4 confers risk to Alzheimer'sIn humans, there are different versions of the APOE gene, including APOE2, APOE3, and APOE4. Everyone has two copies of it, meaning that you may have E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, or E4/E4. It has been established t...
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Triclosan found to negatively affect colonic inflammation
Triclosan found to negatively affect colonic inflammationA team consisting of scientists at the University of Massachusetts, the University of Wisconsin-Madison, University of California, Harvard Medical School, Northwestern University in the USA, Xi’an Jiaotong University, ...
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Adenovirus reprogrammed to target αvβ6 may treat ovarian cancer
Adenovirus reprogrammed to target αvβ6 may treat ovarian cancerA new study brings hope for selectively targeting cancer cells by using a reprogrammed virus. The full paper (Ad5NULL-A20-a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ova...
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Role of non-coding RNA in prostate cancer progression
Role of non-coding RNA in prostate cancer progressionDr. Arul Chinnaiyan, professor of urology and director of the Michigan Center for Translational Pathology, and his team have recently discovered that a non-coding RNA called ARLNC1 could play a role in the progression of...
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Exercise may reduce C-reactive protein and improve prognosis in breast cancer patients
Exercise may reduce C-reactive protein and improve prognosis in breast cancer patientsModerate to vigorous exercise has been shown to modulate the concentrations of an indicator of inflammation -- C-reactive protein -- in patients with breast cancer, according to a paper titled "Changes in physical activi...
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Short-term fasting improves the health of your intestines
Short-term fasting improves the health of your intestinesA study conducted by MIT researchers has demonstrated that the reduced regenerative capacity of intestinal stem cells due to age might be restored by fasting. This discovery points out a strategy for enhancing intestinal...
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Platinum-based chemotherapy could improve survival in pancreatic cancer, study finds
Platinum-based chemotherapy could improve survival in pancreatic cancer, study findsAccording to a study published in the Journal of the American College of Surgeons, some of the patients with pancreatic cancer would benefit from platinum-based chemotherapy. The study was carried out by researchers...
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WAY-316606 may treat hair loss
WAY-316606 may treat hair lossA study described in PLoS Biology found that an experimental drug for osteoporosis, called WAY-316606, can significantly stimulate human hair follicles. The discovery highlights the need for further investigation into th...
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Fermentable fiber in the diet helps combat the flu
Fermentable fiber in the diet helps combat the fluHealth experts emphasize the importance of increasing fiber in your diet. Dietary fiber, unlike other food components that will be broken down and absorbed by your body, is not digested much but instead passes relatively...
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Scientists have now gained new insights into a cancer-causing virus.
Scientists have now gained new insights into a cancer-causing virus.A virus, called human T-cell leukemia virus type 1 (HTLV-1), is known to contribute to leukemia and lymphoma. HTLV-1 is a retrovirus, and like another retrovirus HIV, it also affects T cells, which are vital cells in the...
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Premeal consumption of low-fat yogurt improves postprandial metabolism and reduces inflammation markers
Premeal consumption of low-fat yogurt improves postprandial metabolism and reduces inflammation markersIn a study published in Journal of Nutrition, researchers at the University of Connecticut report that eating low-fat yogurt before meal can reduce inflammation after meal and markers of endotoxin exposure in healthy pre...
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CDK5 inhibition suppresses glioma stem cell self-renewal
CDK5 inhibition suppresses glioma stem cell self-renewalGlioblastoma is a fast-growing, aggressive type of tumor that grows from the supportive tissue of the brain. Prognosis of the disease is very poor that even with optimal therapy, survival is usually only about 12 to 15 m...
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Research shows urea cycle enzymes are repressed in kidney cancer
Research shows urea cycle enzymes are repressed in kidney cancerNew research by the University of Pennsylvania now provides insights into the biology of kidney cancer. Existing therapies only benefit some of the patients with kidney cancer. The new research may lead to novel therapeu...
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Inhibition of chloride transport may treat fragile X syndrome
Inhibition of chloride transport may treat fragile X syndromeA new study carried out by researchers from Northwestern University Feinberg School of Medicine and David Geffen School of Medicine at UCLA has now provided a novel way to combat autism. Fragile X syndrome (FXS) is a ...
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A type of immune cells promote metastasis in ovarian cancer
A type of immune cells promote metastasis in ovarian cancerOvarian cancer is often diagnosed at the advanced stages, such as when the tumor has already spread to other parts through the peritoneal cavity. This contributes to poor prognosis in ovarian cancer. If there are ways to...
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ELK-1 suggested as a druggable target for depression
ELK-1 suggested as a druggable target for depressionDepression is a mood problem and is one of the most common causes of disability. People with depression lose interest in things that they previously love and often experience many negative emotions such as sadness and lo...
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Gut bacteria may affect progression of NAFLD via modulating inflammation
Gut bacteria may affect progression of NAFLD via modulating inflammationIt seems unbelievable that the human body contains more microorganisms than human cells. But it's true. It was once estimated that there are about 100 trillion bacterial cells and 10 trillion human cells in our bodies. T...
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Blocking glucose transport by inhibiting Glut1 is a promising way to treat psoriasis
Blocking glucose transport by inhibiting Glut1 is a promising way to treat psoriasisNew research from UT Southwestern Medical Center has identified a novel way to combat the inflammatory skin disease psoriasis. Described in the journal Nature Medicine, the study (Differential glucose requir...
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New clues to the cause of hair graying
New clues to the cause of hair grayingWhen the human body is challenged by a severe disease, infection, or other types of stress, the hair may turn gray. But why this occurs remains a mystery. New research finds that the reason may lie in the im...
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Cambinol inhibits the spread of tau
Cambinol inhibits the spread of tauAlzheimer's disease (AD) is a tauopathy (any neurodegenerative disease that involves pathological aggregation of tau protein). The presence of neurofibrillary tangles that consist primarily of the protein tau in the brai...
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Living near to a major road increases children's risk of asthma
Living near to a major road increases children's risk of asthmaA growing number of people in some developed countries including the USA develop a long-term illness called asthma, which predominantly affects the airways of the lungs and triggers difficulty breathing. It'...
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NAT10 inhibition offers therapeutic opportunities for premature aging and normal aging
NAT10 inhibition offers therapeutic opportunities for premature aging and normal agingHutchinson-Gilford Progeria Syndrome (HGPS) is a merciless illness; Most of the patients with HGPS die before the age of 13. These deaths usually result from atherosclerosis and related complications, including heart att...
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A class of anti-cancer drugs shows promise in treating TB
A class of anti-cancer drugs shows promise in treating TBTuberculosis (TB), a contagious illness caused by a bacterium called Mycobacterium TB (Mtb), is still one of the top killers among mankind, ranking above HIV/AIDS, despite the remarkable advance in prevention, diagnosis,...
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NLRP3 inflammasome contributes to diabetic eye disease
NLRP3 inflammasome contributes to diabetic eye diseaseA study carried out by researchers from the University of Missouri, Columbia, USA, has identified novel strategies to deal with eye problems resulting from diabetes. Without appropriate treatment, the metabo...
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Why does intensive exercise reduce appetite?
Why does intensive exercise reduce appetite?Have you ever noticed the phenomenon that your appetite is poor within hours after intense workouts? Now a new scientific research reveals the reason underlying this phenomenon. When engaged in intense exerc...
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Acyclic retinoid suppresses MYCN to inhibit HCC
Acyclic retinoid suppresses MYCN to inhibit HCCA study, conducted by researchers from RIKEN Center for Life Science Technologies, Kanazawa University, Tottori University, Nagoya University, KOWA Co. Ltd, The Jikei University School of Medicine, Tokyo Medical and Dent...
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Lowering acrolein inhibits progression of Parkinson's disease in rats
Lowering acrolein inhibits progression of Parkinson's disease in ratsResearchers from Purdue University have implicated a molecule called acrolein in the pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease (AD), which affect...
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Vitamin D deficiency might confer risk of diabetes
Vitamin D deficiency might confer risk of diabetesOur bodies need many important nutrients to function properly. Vitamin D is one of such nutrients. Vitamin D can be synthesized in the body in response to sun exposure. So it is not an essential dietary factor. ...
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Study provides insights into amplification of the genetic risk for rheumatoid arthritis upon exposure to environmental pollutants
Study provides insights into amplification of the genetic risk for rheumatoid arthritis upon exposure to environmental pollutantsA new study now sheds light on why exposure to environmental pollutants can amplify the genetic risk for rheumatoid arthritis (RA), the most common type of autoimmune arthritis. Published ahead of print Apri...
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How does HIV evade anti-viral immunity?
How does HIV evade anti-viral immunity? Researchers from Trinity College Dublin in Ireland and University of Oxford in the United Kingdom have identified a mechanism by which HIV evades anti-viral immune responses. Viral illnesses can be hard to d...
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Research suggests a protective role of large SOD1 fibrils in ALS
Research suggests a protective role of large SOD1 fibrils in ALSOn 14 March 2018, the world-famous theoretical physicist, cosmologist, author, and director of research, Stephen William Hawking, died after decades of struggling with amyotrophic lateral sclerosis (ALS), an incurable di...
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EB3 protein: a promising therapeutic target against HCMV infection
EB3 protein: a promising therapeutic target against HCMV infectionA new study now deepens our understanding of how an extremely common human virus establishes its infection and provides novel targets for anti-viral therapies. Human cytomegalovirus (HCMV), also referred to ...
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Scientists identify intestinal target cell of norovirus
Scientists identify intestinal target cell of norovirusA study, carried out by researchers from Washington University School of Medicine, the University of Illinois at Chicago College of Medicine, Harvard T. H. Chan School of Public Health, New York University School of Medi...
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A study demonstrates the efficacy of a peptide drug in AML
A study demonstrates the efficacy of a peptide drug in AMLA study, led by researchers from Albert Einstein College of Medicine and Aileron Therapeutics, has demonstrated the therapeutic potential of an investigational drug called ALRN-6924 in the life-threatening cancer acute m...
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FOXF1 protein suppresses pulmonary fibrosis
FOXF1 protein suppresses pulmonary fibrosisThe FOXF1 gene suppresses pulmonary fibrosis (scarring of the lungs), according to a study by researchers from the Perinatal Institute of Cincinnati Children's Hospital Research Foundation. Therefore, FOXF1 and related p...
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Toxicity of apolipoprotein E4 could be ameliorated
Toxicity of apolipoprotein E4 could be amelioratedA new study, led by researchers from the University of California and Gladstone Institute of Neurological Disease, has now shed light on the toxicity of apolipoprotein E4 in human neurons. Genes are one of m...
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Novel host-modulating therapy for bacterial pneumonia
Novel host-modulating therapy for bacterial pneumoniaDr. Hongbo Luo, a researcher at Harvard Medical School and Children's Hospital Boston, and co-workers have recently found a novel, effective way to treat bacterial pneumonia. Bacterial pneumonia is an inflam...
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