Study deepens understanding of pulmonary fibrosis
Study deepens understanding of pulmonary fibrosisA new study (PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production) in Science Translational Medicine has shown that existing drugs may be repurposed to treat...
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A preventive strategy for diabetes
A preventive strategy for diabetesDiabetes is a pandemic of major public health importance. Many factors have been found to increase the risk of diabetes. Among them, obesity is the most significant risk factor for type 2 diabetes and other metabolic con...
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Novel therapy may benefit some patients with triple-negative breast cancer
Novel therapy may benefit some patients with triple-negative breast cancerBreast cancer is one of the most common invasive cancers in women. There are many types of breast cancer. Among them, triple-negative breast cancer is relatively hard to treat. Triple-negative breast cancer defined as ca...
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Exercise improves muscle function by enhancing autophagy
Exercise improves muscle function by enhancing autophagyIf conditions permit, regular exercise is recommended to help you stay healthy. Now a new study provides further proof of how exercise benefits your body. Described in Scientific Reports, a paper (Exercise p...
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How does cancer get so much energy to support rapid growth?
How does cancer get so much energy to support rapid growth?Cancer is characterized by uncontrolled cell growth and proliferation. To support such rapid growth, cancer needs a larger amount of energy. The major source of energy for cells is glucose. Cancer consumes so much glucos...
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Study shows how inflammation is regulated by the biological clock
Study shows how inflammation is regulated by the biological clockFindings of a new study would have implications for the treatment of inflammatory disorders. The study, entitled "Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2," is published in PNAS. ...
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Dietary fiber has neurological benefits
Dietary fiber has neurological benefitsDuring aging, microglia -- a type of neuronal support cells occurring in the central nervous system that functions primarily as immune cells -- become inflamed and hypersensitive to signals from the peripheral immune sys...
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Nanoparticle-based gene therapy shows promise in treating prostate cancer
Nanoparticle-based gene therapy shows promise in treating prostate cancerMany anti-cancer drugs work by targeting the proteins or pathways that are overactive. A new study now tries an alternative way: targeting those that are lost in cancer. Tumor suppressors are a group of gene...
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The hormone cortisol is involved in AML
The hormone cortisol is involved in AMLDescribed in the journal "Cellular & Molecular Immunology", a study (Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression) has shown that an important huma...
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Malaria protein helps diagnose cancer
Malaria protein helps diagnose cancerCancer is a hot research topic, as it's responsible for large number deaths each year. A cancer diagnosis is often considered a death sentence. But in fact, there are many strategies to help people with cancer live longe...
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Understanding of pathogen-host interactions assists development of anti-TB drugs
Understanding of pathogen-host interactions assists development of anti-TB drugsA new study identifies novel interactions between the bacterium Mycobacterium tuberculosis (Mtb) and host cells. The study (An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiv...
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Why do some people with Alzheimer's signs do not develop dementia?
Why do some people with Alzheimer's signs do not develop dementia? Why do some individuals with hallmarks of Alzheimer's disease do not show disease symptoms? Now, researchers from the University of Texas Medical Branch and Oregon Health and Science University have found the answer to t...
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A chaperone protein could be targeted to treat Parkinson's disease, study finds
A chaperone protein could be targeted to treat Parkinson's disease, study findsA study led by researchers from the University of Alabama at Birmingham has shown that a chaperone protein, named 14-3-3, would be the key to understanding the pathogenesis of Parkinson's disease and developing therapeut...
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Splicing alterations in CPEB4 may correlate with autism
Splicing alterations in CPEB4 may correlate with autismAutism, or autism spectrum disorder (ASD), is a heritable disorder. In addition to genetic factors, environmental factors are also very important during its development. Up to now, a large number of genes have been found...
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New research may reduce the need for liver transplants
New research may reduce the need for liver transplantsA multinational team has found that suppressing a process called senescence can restore the regenerative ability of injured liver, preventing death from liver damage. The liver is an important organ. Its mai...
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Potential therapeutic for low platelets
Potential therapeutic for low plateletsPlatelets, a specific type of blood cell, are very important to our health. When we bleed, the platelets in our bodies exert their clotting function and stop bleeding. However, some people suffering from thrombocytopenia...
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SMURF1 protein may be the key to cocaine relapse
SMURF1 protein may be the key to cocaine relapseDrug abuse is a big social problem. It affects not only the drug users themselves, but also their families and other people. For example, certain infectious diseases are more prevalent among drug users, and drug users ar...
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Scientists identified a genetic cause of pachygyria
Scientists identified a genetic cause of pachygyriaA new research has identified a mutation in a gene called CTNNA2 that is responsible for pachygyria, a severe developmental brain disorder. The finding provides insights into molecular processes that control brain develo...
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Zc3h8 overexpression contributes to breast cancer
Zc3h8 overexpression contributes to breast cancerResearchers from Villanova University have found a gene implicated in breast cancer. The discovery would extend our understanding of the life-threatening disease. Prof. Janice Knepper at Villanova University has been ...
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Scientists find a way to make paralyzed mice walk again!
Scientists find a way to make paralyzed mice walk again!Every year, a number of people become paralyzed for various reasons such as a traffic accident. They have an eager desire of regaining the ability of movement. Now, scientists have found a way to make paraly...
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A new class of drugs effectively fights cancer without causing side effects
A new class of drugs effectively fights cancer without causing side effectsDescribed in Nature, a study has found a new class of anti-cancer drugs that puts cancer cells to 'sleep'. Unlike conventional chemotherapy and radiotherapy, these new drugs do not cause DNA damage and related side effec...
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A well-studied protein may overcome cocaine relapse
A well-studied protein may overcome cocaine relapseIt's extremely hard to overcome drug addiction. Scientists in this field have been long seeking for ways to prevent drug relapse. Now, a new study published in Addiction Biology has shown that a common prote...
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Polycystic ovary syndrome may increase the rates of autism in your children
Polycystic ovary syndrome may increase the rates of autism in your childrenResearchers from the University of Cambridge and Yale University School of Public Health have shown that polycystic ovary syndrome, a hormonal condition that occurs in approximately 5 to 10 percent of women of reproducti...
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Targeting YAP unleashes immune system to attack cancer
Targeting YAP unleashes immune system to attack cancerA new research, carried out by an international team, has unraveled that blocking a known protein may unleash the immune system to attack cancer and improve the efficacy of immunotherapies. Regulatory T cell...
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Novel peptide-based vaccine shows strong protection against influenza
Novel peptide-based vaccine shows strong protection against influenzaThe flu, or called influenza, is a widespread, highly contagious disease caused by influenza viruses. Despite the presence of flu vaccines, about 291,000 to 646,000 people die of the disease annually, according to the Wo...
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Researchers find a non-human primate model of Batten disease
Researchers find a non-human primate model of Batten diseaseBatten disease, also known as neuronal ceroid lipofuscinosis (NCL), is an extremely rare and fatal neurodegenerative disorder that impairs many basic bodily functions.  Affected children often die of the disease at ...
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Study reveals IL-12 confers protection against childhood malaria
Study reveals IL-12 confers protection against childhood malariaA new study led by Curtin University has demonstrated that a protein called IL-12 helps combat malaria in newborns. Malaria is a serious disease caused by parasites that are mainly transmitted by mosquitoes....
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LRRK2 overactivity is a cause of Parkinson's disease
LRRK2 overactivity is a cause of Parkinson's diseaseNew research has shown that a gene previously shown to associate with a small proportion of Parkinson's disease (PD) cases may actually account for most cases of the disease. PD is a disease that primarily o...
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Blood test predicts whether patients with prostate cancer would benefit from ARS inhibitors
Blood test predicts whether patients with prostate cancer would benefit from ARS inhibitors Scientists have shown that a blood test is capable of predicting treatment response in suffers of advanced prostate cancer, according to a new study (Assessment of the Validity of Nuclear-Localized Androgen Receptor Spli...
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Physical exercise increases the likelihood of successful aging
Physical exercise increases the likelihood of successful agingHave you ever think about what it would be when you get older? When you get old, you don't seem to have to work and have lots of free time to do what you want to do. Sounds pretty good, doesn't it? But aging often means ...
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Restoration of mitochondrial function diminishes aging symptoms in mice
Restoration of mitochondrial function diminishes aging symptoms in miceTurning on a mutated gene responsible for mitochondrial dysfunction led to wrinkled skin and hair loss in mice, and these aging symptoms were reversed by turning off this gene. This is the finding of a mouse study by car...
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Allergic reactions may confer protection against skin cancer
Allergic reactions may confer protection against skin cancerMany people experience allergic reactions, ranging from mild to severe. For example, mango allergies commonly occur on the skin around the mouth, which trigger itching and burning; peanut allergies can trigger skin rashe...
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Why do men recover faster from the flu than women?
Why do men recover faster from the flu than women?There are differences in physiology between women and man. One example is that men generally recover faster from the flu than women. Now, a new study provides insights into this sex difference. Described in ...
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A particular muscarinic receptor could be targeted to improve multiple sclerosis
A particular muscarinic receptor could be targeted to improve multiple sclerosisA new research has identified a drug target for multiple sclerosis (MS), the most widespread disabling neurological condition among young adults. Published in The Journal of Neuroscience, the research (Muscarinic rece...
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Metabolites of omega-3 fatty acids exhibit anti-tumor effect in bone cancer
Metabolites of omega-3 fatty acids exhibit anti-tumor effect in bone cancerIn a paper (Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides) published in the Journal of Medicinal Chemistry, researchers from the University of Illinois report that products of omega-3 fatty acid metaboli...
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Antisense oligonucleotides may be an efficacious therapy for ALS
Antisense oligonucleotides may be an efficacious therapy for ALSAmyotrophic lateral sclerosis (ALS) is a debilitating disease that affects neurons in the central nervous system, impairing the function of voluntary muscles. Over time, patients with ALS become less able to chew, walk, ...
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Fat appears to be the only macronutrient that causes obesity
Fat appears to be the only macronutrient that causes obesityObesity is an increasingly important problem worldwide. Numerous efforts have been made to uncover the mechanisms underlying energy intake, storage, and expenditure in the body. Such studies would help develop more effec...
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An explanation for nonresponse to checkpoint inhibitors in some cancer patients
An explanation for nonresponse to checkpoint inhibitors in some cancer patientsA research has uncovered that some tumor cells co-express two checkpoint proteins, and this co-expression may explain why checkpoint inhibitors fail to work in some cancer patients. Our bodies' immune system...
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Only some people can benefit from a Mediterranean diet
Only some people can benefit from a Mediterranean dietEating a Mediterranean diet is known to have many health benefits. Now a new study has provided novel evidence to support the health benefits of a Mediterranean diet. The study, carried out researchers at IRCCS Istituto ...
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Vitamin D may have no significant effects against brain disorders
Vitamin D may have no significant effects against brain disordersWhen it comes to vitamin D, many people know that it has a lot of health benefits, such as promoting the absorption of calcium. Recent studies have suggested that vitamin D has a neuroprotective role and tha...
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CD271 may serve as a diagnostic and prognostic marker for a subgroup of brain tumor
CD271 may serve as a diagnostic and prognostic marker for a subgroup of brain tumorA study, carried out researchers from the University of Manitoba, Ottawa Hospital Research Institute, Hospital for Sick Children, Kansas University Medical Center, and the  University of Calgary, has uncovered a dia...
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A breakthrough in HIV prevention
A breakthrough in HIV preventionA research published in The Lancet has demonstrated the great potential of new HIV-1 vaccine regimens to prevent HIV-1 infection. The research represents a breakthrough in HIV prevention but more investigation is require...
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Research finds a way to reverse pathology that causes dementia
Research finds a way to reverse pathology that causes dementiaYou may not be unfamiliar with the problem of population aging. Population aging is both a social problem and an economic problem. It refers to a process in which the median age in the population of a region is increasin...
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Solvents confer risk for multiple sclerosis
Solvents confer risk for multiple sclerosisExposure to solvents such as paint and varnish may increase the risk of developing a disabling disease of the central nervous system, especially when people carry risk genes. This is the discovery of a new study (Organic...
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CMV improves immunity in old mice, study finds
CMV improves immunity in old mice, study findsWhy are the elderly more likely to get infectious diseases compared with the young? The reason lies in our immune systems. As people age, the immune system becomes less effective in multiple ways. Firstly, the immune sys...
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C6orf106 identified as an inhibitor of antiviral response
C6orf106 identified as an inhibitor of antiviral responseCSIRO scientists in Australia have discovered that the C6orf106 gene (simply known as C6) inhibits the innate antiviral response. The discovery would have intriguing implications for antiviral immunity, autoimmune disord...
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TRAF7 variants linked to human development disorder
TRAF7 variants linked to human development disorderA new study has identified a link between mutations in the TRAF7 gene and a multisystem disorder. In addition, there might also be an association between TRAF7 and other diseases such as cancer and RASopathy. ...
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TWIK2 channel mediates inflammation, study finds
TWIK2 channel mediates inflammation, study findsNovel way to control inflammation A new study has identified a potential target for anti-inflammatory therapies. The study was carried out by scientists from the University of Illinois College of Medicine and St. Jude...
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Effect of ARID1A on transcription and tumorigenesis identified
Effect of ARID1A on transcription and tumorigenesis identifiedScientists from The Wistar Institute and the University of Pennsylvania have gained new insights into the role of the tumor suppressor ARID1A in transcription and tumorigenesis. Described in the journal Cell Reports, the...
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Two herpesviruses found to contribute to Alzheimer's disease
Two herpesviruses found to contribute to Alzheimer's diseaseA large number of diseases have been identified to affect humans. Progress in medicine has greatly improved the treatment of many diseases. For example, tuberculosis or TB once killed one out of every seven people in som...
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