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LIGHT found to correlate with inflammatory skin disease
LIGHT found to correlate with inflammatory skin diseaseA team, composed of nine researchers from the La Jolla Institute for Allergy and Immunology (LJI), has found that a cytokine called LIGHT could be a therapeutic target for treatment of inflammatory skin diseases. ...
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Blockage of G-CSF in brain treats cocaine addiction in mice
Blockage of G-CSF in brain treats cocaine addiction in miceCocaine is a highly addictive drug that can cause huge harm to a person's health and well-being. The substance was first synthesized from the leaves of the coca plant in 1980. Cocaine abuse has become an important social...
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Explanation for why only some obese people are prone to diabetes
Explanation for why only some obese people are prone to diabetesThe negative health consequences of obesity have been well-established. Obesity is a major risk factor for metabolic diseases like type 2 diabetes and cardiovascular disease. Interestingly, recent evidence reveals that n...
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Upregulation of ApoE reduces immune suppression and promotes anti-cancer immune response
Upregulation of ApoE reduces immune suppression and promotes anti-cancer immune responseA team, composed of researchers from the Rockefeller University, Downstate Medical Center, Cedars-Sinai Medical Center, the University of California, Memorial Sloan Kettering Cancer Center, and Rgenix, has found an appro...
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Study provides potential way to treat inflammatory bowel disease
Study provides potential way to treat inflammatory bowel diseaseFindings of a new study by researchers from Weill Cornell Medicine in the USA would lead to novel treatments for patients with inflammatory bowel diseases. The researchers have identified a group of immune cells, known a...
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Critical cells involved in scleroderma identified
Critical cells involved in scleroderma identifiedScleroderma, a term that is often used interchangeably with systemic sclerosis, refers to an autoimmune disease that mainly affects the skin and the connective tissue. Regardless of age and gender, all people may be affe...
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New tool to assess the effect of immunotherapy
New tool to assess the effect of immunotherapyA team, led by Prof. Preet Chaudhary at the University of Southern California, has developed a new tool to test the effect of immunotherapy. The tool may also apply to other types of therapeutics and may be used to scree...
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Research finds new genetic link to severe obesity
Research finds new genetic link to severe obesityAlmost everyone knows that maintaining a healthy weight is important. To determine whether your body weight is healthy, you can calculate your body mass index (BMI), which is reported as weight in kilograms (kg) divided ...
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Leptin regulates glucose homeostasis during starvation, study finds
Leptin regulates glucose homeostasis during starvation, study findsThe brain accounts for less than 2% of the body's weight. However, even at rest, it consumes approximately 20% of the body's energy. Why does the brain have so large an energy budget? Although this question has not been ...
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Scientists identify gut bacteria that increase immunotherapy efficacy
Scientists identify gut bacteria that increase immunotherapy efficacyImmunotherapy has significantly improved cancer treatment. But less than half of patients with melanoma respond well to immunotherapy. If we can find ways to increase their response rate, it will lead to considerable imp...
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Why does drinking alcohol increase your cancer risk?
Why does drinking alcohol increase your cancer risk?Drinking too much alcohol is detrimental to your health. Nearly everyone knows it. It's estimated that 3.6 % of all cancer cases worldwide are attributable to alcohol drinking. But the molecular mechanism of how alcohol ...
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Inhibition of a host enzyme suppresses Ebola infection
Inhibition of a host enzyme suppresses Ebola infectionThe recent outbreaks of Ebola virus have attracted the world's attention. The virus can cause life-threatening illness in people, but at present, no FDA-approved vaccine or medicine is available for it. Thus, it is imper...
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Engineering antibodies in vivo fights autoimmune disorders
Engineering antibodies in vivo fights autoimmune disordersUnder normal conditions, the immune system protects the body from foreign invaders, such as viruses, bacteria, fungi, and parasites. The immune system also helps to fight cancer by detecting and destroying abnormal cells...
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Unique mechanism of cancer metastasis identified
Unique mechanism of cancer metastasis identifiedDescribed in the Proceedings of the National Academy of Sciences, a study titled "RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases" has shown that the RSK2 protein may drive the m...
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What causes postpartum depression?
What causes postpartum depression?The arrival of a new baby is an exciting and happy thing for a family. But some new mothers experience extreme sadness, hopelessness, anxiety, excessive crying, sleep problems, physical pains, eating too little or too mu...
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Reactivation of FoxO3 represents a way to treat pulmonary fibrosis
Reactivation of FoxO3 represents a way to treat pulmonary fibrosisPulmonary fibrosis, a medical condition in which the lungs get scarred over time, can cause severe breathing problems. The pathogenesis of pulmonary fibrosis has not been fully understood, hindering the development of mo...
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The drug hydralazine may have therapeutic effect against aging-related disorders, study finds
The drug hydralazine may have therapeutic effect against aging-related disorders, study findsHydralazine, a drug used to treat high blood pressure and heart failure, successfully extends healthy lifespan (about 25%) in the roundworms C. elegans by activating the NRF2/SKN-1 signaling pathway. This is...
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Different people may eat different diets in order to prevent colorectal cancer
Different people may eat different diets in order to prevent colorectal cancerA team of researchers from Centro Nacional de Investigaciones Oncológicas (CNIO) and Hospital Universitario Ramón y Cajal in Spain has found that what you eat may influence the risk of colorectal cancer. The discovery ...
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