Scientists have discovered a new drug targeting the related receptors in sarcomas
Scientists have discovered a new drug targeting the related receptors in sarcomasSarcomas are malignant tumors derived from mesenchymal tissue (including connective tissue and muscle), which often occurs in the skin, subcutaneous, periosteum and long bone at both ends.  Sarcomas are rare tumors,...
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Scientists give new insight to muscular dystrophy patients
Scientists give new insight to muscular dystrophy patientsFacioscapulohumeral muscular dystrophy, referred to as FSHD, is a genetic muscular disorder, which is mainly characterized by progressive weakness and atrophy of skeletal muscle. So far, more than 850,000 people worldwid...
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A hopeful drug target for treating triple negative breast cancer
A hopeful drug target for treating triple negative breast cancerIt is reported that the incidence of breast cancer in China continues to rise, ranking the first among female malignant tumors, and is still going up at the rate of one to three percent per year. Triple-negative breast c...
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A mammalian protein has been found to hold stem cells young
A mammalian protein has been found to hold stem cells youngRoyal jelly is a milky white or yellowish slurry secreted from the head gland of young worker bees after collecting pollen and honey. It is like the milk of mammals and extremely nutritious and immune function. Bees (...
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Discovery of a new inflammatory inhibitor
Discovery of a new inflammatory inhibitorInflammation is the defensive response of a living tissue with a vascular system to a damage factor, mainly manifested as redness, swelling, fever, pain, and dysfunction. Vascular responses are central to the inflammator...
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USP18 plays a dual role in the immune system causing people easier to be attacked by bacteria
USP18 plays a dual role in the immune system causing people easier to be attacked by bacteriaBacterial infection is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogens invading the blood circulation to grow and reproduce and producing toxins and other metabolites. Clinically, it ...
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A promising treatment for type II diabetes has been discovered
A promising treatment for type II diabetes has been discovered Glucose, a sugar that is the main source of energy for cells that make up muscle and other tissues. Glucose mainly comes from food and liver. In most conditions, glucose is absorbed into the blood and enters the cell wit...
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Scientists discovered a feasible drug target for treating hypertension
Scientists discovered a feasible drug target for treating hypertensionNormal blood pressure fluctuates within a certain range with the change of internal and external environment. However, hypertension is mainly characterized by the increase in systemic arterial blood pressure, which can b...
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Dnak protein has been found to promote the development of cancer
Dnak protein has been found to promote the development of cancerCancer is increasingly endangering human health, so making certain the cause of the cancer is an important prerequisite for preventive treatment. The existing research results show that the occurrence of cancer is a mult...
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ZFP64-a drug target for treating mixed lineage leukemia
ZFP64-a drug target for treating mixed lineage leukemiaLeukemia is a kind of hematopoietic stem cell malignant clone disease. Because of its high mortality, it is also called blood cancer. Mixed lineage leukemia (MLL) is a typical type of leukemia, named after the chromosoma...
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An underlying therapy may effectively cure osteoarthritis
An underlying therapy may effectively cure osteoarthritisA bone joint is an indirect connection between bone and bone. Based on the structure of bone joints, our bodies can move freely. The ends of these bones are covered with a type of tissue called cartilage, which can prote...
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What details shall we pay attention to in the western blotting experiment?
What details shall we pay attention to in the western blotting experiment?The introduction to western blotting Western blotting, also known as protein immunoblotting, is an important laboratory technique that allows for specific identification and characterization of proteins. So...
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 A DNA vaccine can reduce two toxic proteins related to Alzheimer's disease
A DNA vaccine can reduce two toxic proteins related to Alzheimer's diseaseAlzheimer's disease, also known as senile dementia, is a kind of central nervous system degeneration disease and the most common type of dementia in old age. Alzheimer's disease begins with a hidden attack and has a chro...
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A potential therapy for impeding pancreatic cancer progression
A potential therapy for impeding pancreatic cancer progressionPancreatic cancer is a highly malignant tumor in the digestive tract, which is characterized by rapid progression, early metastasis, insensitive to chemotherapy and radiotherapy. Pancreatic cancer is caused by excessivel...
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Stopping melanoma metastasis by cutting off interactions between a pair of proteins
Stopping melanoma metastasis by cutting off interactions between a pair of proteinsMelanoma is a common skin tumor which is caused by excessively proliferating of abnormal melanocytes. Melanocytes are skin cells that produce melanin, a brown pigment that gives skin color and protects the inner layer of...
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A new mechanism for controlling the main cancer regulator
A new mechanism for controlling the main cancer regulatorMutations in RAS proteins cause a variety of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a primary problem. A finding that appeared in the journal S...
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What on earth causes itching and scratching?
What on earth causes itching and scratching?Itching is a subjective sensation that causes an immediate desire to scratch. The most common symptom of skin disease is pruritus. Due to different skin diseases and individual sensitivity, the severity of pruritus can b...
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A drug is expected to combat myotubular myopathy
A drug is expected to combat myotubular myopathyMyotubular myopathy is one of the congenital muscular dystrophy, which is mainly caused by the disorder during the process of myofibril forms myotubule. The disorder results in bad myotubule, thus breaking off the develo...
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The mystery of cancer genetic problem is uncovered
The mystery of cancer genetic problem is uncoveredFor tumors, their cells frequently lose their normal ability to control growth and thus continue to differentiate and proliferate. So tumors need to provide cancer cells with more energy supplement for their rapid growth...
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A fresh mechanism related to bone formation is found
A fresh mechanism related to bone formation is foundIn the early development of the embryo, mesodermal mesenchymal cells transform to pre-osteoblasts in the location that will be formed into bone, then pre-osteoblasts divide into osteoblasts, lastly, osteoblasts mature in...
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A new bellwether for anti-cancer antibodies
A new bellwether for anti-cancer antibodiesWhen people talk about cancer, they often feel panicked and powerless. Because cancer starts hidden, its malignancy degree is high and state of an illness change is fast, the survival rate of the people suffered from can...
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Do you know how your muscles develop?
Do you know how your muscles develop?Muscles are an important part of our bodies, they play an indispensable role in the movement. Although we are not strange to muscles, do you really know how your muscles form? Things of one kind come togethe...
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Cancer cells lacked tumor protein p53 can survive better in the unfavorable environment
Cancer cells lacked tumor protein p53 can survive better in the unfavorable environmentA fresh finding published in eLife revealed that loss of tumor protein p53 is helpful to cancer cells' growth in a hostile environment. When a cell divides, its genetic material, DNA is replicated, then the two copies...
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Zinc is involved in the development of autism
Zinc is involved in the development of autismAutism is a developmental disease that induced by the imbalance of nervous system formation. The latest statistics show that the incidence of autism in China is on the rise. In other words, more and more peo...
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A new mechanism for regulating the sleep of fruit flies
A new mechanism for regulating the sleep of fruit fliesSleep is a form of rest. Almost one-third of our life is spent within sleep. Sleep can help us remove tiredness, restore the spirit and the function of the brain, conserve energy, enhance the memory and immunity. Sleep i...
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Gut bacteria can control animals' motion
Gut bacteria can control animals' motionA fresh research has been published in the magazine "Nature" recently. The result revealed that gut bacteria can get command of the motion of fruit flies and recognize the neurons involved in these response. ...
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The boys have social interaction and neural defects when their mothers take cannabinoids during pregnancy
The boys have social interaction and neural defects when their mothers take cannabinoids during pregnancyA research published on the eLife showed that gravidae took cannabinoids during pregnancy could cause their male offspring social interaction and neural defects, but the female ones can escape from the influence. ...
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Discovery of a new antiviral agent
Discovery of a new antiviral agent Researchers at the University of Eastern Finland have found new compounds that can target bacterial infections, potentially providing the solution to solving antibiotic resistance. In recent years, studies h...
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A genetic network relevant for autism have been found
A genetic network relevant for autism have been found The researchers from Donnelly center published an essay about the genetic network linked to autism. The result will contribute to developing a new treatment for autism. The postdoctoral researcher Thomas Gonatopoul...
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Scientists are searching for a novel way to fight tuberculosis in the soil
Scientists are searching for a novel way to fight tuberculosis in the soilTuberculosis also called TB, is a disease caused by a mycobacteria infection. TB usually causes lung infections, it can infect other parts of the body as well. Most people are asymptoma...
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UA scientists aim to identify drug targets for rhabdomyosarcoma
UA scientists aim to identify drug targets for rhabdomyosarcomaRhabdomyosarcoma (RMS) is a rare type of skeletal muscle cancer known as RMS, which primarily affects pediatric patients.RMS has serious effects on children’s health. Despite in-depth studies on the...
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A new strategy-blocking tumor immunosuppression
A new strategy-blocking tumor immunosuppressionThe team, from UCLouvain, WELBIO, VIB and Ghent University, analyzed the three-dimensional structure of key proteins that inhibit immune cells, showing how the proteins are accurately assembled in cells, and also explain...
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Study deepens understanding of pulmonary fibrosis
Study deepens understanding of pulmonary fibrosisA new study (PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production) in Science Translational Medicine has shown that existing drugs may be repurposed to treat...
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A preventive strategy for diabetes
A preventive strategy for diabetesDiabetes is a pandemic of major public health importance. Many factors have been found to increase the risk of diabetes. Among them, obesity is the most significant risk factor for type 2 diabetes and other metabolic con...
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Novel therapy may benefit some patients with triple-negative breast cancer
Novel therapy may benefit some patients with triple-negative breast cancerBreast cancer is one of the most common invasive cancers in women. There are many types of breast cancer. Among them, triple-negative breast cancer is relatively hard to treat. Triple-negative breast cancer defined as ca...
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Exercise improves muscle function by enhancing autophagy
Exercise improves muscle function by enhancing autophagyIf conditions permit, regular exercise is recommended to help you stay healthy. Now a new study provides further proof of how exercise benefits your body. Described in Scientific Reports, a paper (Exercise p...
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How does cancer get so much energy to support rapid growth?
How does cancer get so much energy to support rapid growth?Cancer is characterized by uncontrolled cell growth and proliferation. To support such rapid growth, cancer needs a larger amount of energy. The major source of energy for cells is glucose. Cancer consumes so much glucos...
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Study shows how inflammation is regulated by the biological clock
Study shows how inflammation is regulated by the biological clockFindings of a new study would have implications for the treatment of inflammatory disorders. The study, entitled "Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2," is published in PNAS. ...
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Dietary fiber has neurological benefits
Dietary fiber has neurological benefitsDuring aging, microglia -- a type of neuronal support cells occurring in the central nervous system that functions primarily as immune cells -- become inflamed and hypersensitive to signals from the peripheral immune sys...
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Nanoparticle-based gene therapy shows promise in treating prostate cancer
Nanoparticle-based gene therapy shows promise in treating prostate cancerMany anti-cancer drugs work by targeting the proteins or pathways that are overactive. A new study now tries an alternative way: targeting those that are lost in cancer. Tumor suppressors are a group of gene...
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The hormone cortisol is involved in AML
The hormone cortisol is involved in AMLDescribed in the journal "Cellular & Molecular Immunology", a study (Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression) has shown that an important huma...
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Malaria protein helps diagnose cancer
Malaria protein helps diagnose cancerCancer is a hot research topic, as it's responsible for large number deaths each year. A cancer diagnosis is often considered a death sentence. But in fact, there are many strategies to help people with cancer live longe...
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Understanding of pathogen-host interactions assists development of anti-TB drugs
Understanding of pathogen-host interactions assists development of anti-TB drugsA new study identifies novel interactions between the bacterium Mycobacterium tuberculosis (Mtb) and host cells. The study (An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiv...
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Why do some people with Alzheimer's signs do not develop dementia?
Why do some people with Alzheimer's signs do not develop dementia? Why do some individuals with hallmarks of Alzheimer's disease do not show disease symptoms? Now, researchers from the University of Texas Medical Branch and Oregon Health and Science University have found the answer to t...
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A chaperone protein could be targeted to treat Parkinson's disease, study finds
A chaperone protein could be targeted to treat Parkinson's disease, study findsA study led by researchers from the University of Alabama at Birmingham has shown that a chaperone protein, named 14-3-3, would be the key to understanding the pathogenesis of Parkinson's disease and developing therapeut...
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Splicing alterations in CPEB4 may correlate with autism
Splicing alterations in CPEB4 may correlate with autismAutism, or autism spectrum disorder (ASD), is a heritable disorder. In addition to genetic factors, environmental factors are also very important during its development. Up to now, a large number of genes have been found...
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New research may reduce the need for liver transplants
New research may reduce the need for liver transplantsA multinational team has found that suppressing a process called senescence can restore the regenerative ability of injured liver, preventing death from liver damage. The liver is an important organ. Its mai...
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Potential therapeutic for low platelets
Potential therapeutic for low plateletsPlatelets, a specific type of blood cell, are very important to our health. When we bleed, the platelets in our bodies exert their clotting function and stop bleeding. However, some people suffering from thrombocytopenia...
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SMURF1 protein may be the key to cocaine relapse
SMURF1 protein may be the key to cocaine relapseDrug abuse is a big social problem. It affects not only the drug users themselves, but also their families and other people. For example, certain infectious diseases are more prevalent among drug users, and drug users ar...
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Scientists identified a genetic cause of pachygyria
Scientists identified a genetic cause of pachygyriaA new research has identified a mutation in a gene called CTNNA2 that is responsible for pachygyria, a severe developmental brain disorder. The finding provides insights into molecular processes that control brain develo...
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