The discovery of mitochondrial to nuclear messenger protein
The discovery of mitochondrial to nuclear messenger proteinResearchers have identified a protein, G-protein pathway inhibitor 2, also known as GPS2, which moves from the mitochondria of cells to the nucleus in response to stress and fat cell differentiation. Although proteins wi...
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Enzyme USP15 regulates DNA homologous recombination repair and cancer cells response to PARP inhibitors
Enzyme USP15 regulates DNA homologous recombination repair and cancer cells response to PARP inhibitorsResearchers at George Washington University's (GW) cancer center have found that the enzyme USP15 may lead to new treatments for breast and pancreatic cancer. Their findings are published in Nature Communications. ...
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Skin repair may eliminate chronic diseases associated with inflammatory aging
Skin repair may eliminate chronic diseases associated with inflammatory agingThe skin covers the whole body and is the largest organ of the human body. It mainly plays the role of protecting the body, perspiration, feeling cold and heat. The skin has two barrier functions: on the one hand, it pre...
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Researchers have developed a new molecule that can stop the progression of heart failure
Researchers have developed a new molecule that can stop the progression of heart failureHeart failure occurs when the heart is unable to pump enough blood and oxygen to support the body's other organs due to its systolic and (or) diastolic functions are impaired. Heart failure is a serious disease. But it d...
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A pregnant protein could treat geriatric diseases
A pregnant protein could treat geriatric diseasesRecent research conducted by Dr. Amy Wyatt from Flinders University in South Australia has shown that a protein occurred during pregnancy could prevent and treat a series of diseases associated with age, such as Alzheime...
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A protein could be a boimaker in the blood test for early-stage liver disease
A protein could be a boimaker in the blood test for early-stage liver disease Nonalcoholic fatty liver disease (NAFLD) is a condition that affects the liver in the people who do not drink or consume a little alcohol. As the name suggests, NAFLD is characterized by excess storage of fat in liver ce...
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Preventing brain tumors from repairing themselves by blocking a protein
Preventing brain tumors from repairing themselves by blocking a proteinGlioblastoma multiform (GBM) is a rare and highly invasive brain tumor. The tumor is located under the cortex and grows infiltrated. It often attacks several lobes and deep structures and can spread to the contralateral ...
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Trapping pathological proteins that cause many neurodegenerative disorders
Trapping pathological proteins that cause many neurodegenerative disordersTDP-43, short for trans-activation response DNA-binding protein 43, is a versatile DNA and RNA binding protein that functions in intracellular RNA transcription, alternative splicing, and regulation of mRNA stability. RN...
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The possible role for FOXP1 protein in the control of autoimmune diseases has been identified
The possible role for FOXP1 protein in the control of autoimmune diseases has been identifiedResearchers at the Russian Academy of Sciences' Institute of Bioorganic Chemistry (IBCh RAS) and Memorial Sloan Kettering Cancer Center have created a genetic model to help understand how the body inhibits autoimmune and...
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Inhibiting oncogenic proteins can prevent scleroderma fibrosis
Inhibiting oncogenic proteins can prevent scleroderma fibrosisScleroderma is an autoimmune disease of connective tissue, which is characterized by hard and thickened skin, spontaneous scabs, and sometimes in other organs of the body. And it may also cause vascular disease and varyi...
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Researchers have discovered the mechanism of how diabetes causes muscle loss
Researchers have discovered the mechanism of how diabetes causes muscle lossDiabetes is a metabolic disease characterized by hyperglycemia. Due to long-lasting hyperglycemia, diabetes causes chronic damage and dysfunction to various tissues, especially eyes, kidney, heart, blood vessels and nerv...
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A novel checkpoint protein provides a new strategy for cancer immune therapy
A novel checkpoint protein provides a new strategy for cancer immune therapyA study published in the journal Cell characterized a new checkpoint protein on the immune system cells is active in tumors. And the researchers from an international team of Vanderbilt successfully blocked it in combina...
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How do blood vessels protect the brain during inflammation?
How do blood vessels protect the brain during inflammation?Recently, researchers at the University of British Columbia have found how blood vessels protect the brain during inflammation. This finding may lead to new treatments for neurodegenrative diseases such as stroke, multip...
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Can a nerve injury induce amyotrophic lateral sclerosis?
Can a nerve injury induce amyotrophic lateral sclerosis?What is amyotrophic lateral sclerosis?Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Motor neu...
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Gene therapy can durably reverse congenital deafness in mice
Gene therapy can durably reverse congenital deafness in miceCongenital deafness is deafness that is already present after birth and is classified into hereditary and non-hereditary. Nonsyndromic in hereditary deafness accounts for about 80%. Most patients with non-syndromic conge...
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Discover new deadly factors against melanoma in mice
Discover new deadly factors against melanoma in miceMelanoma is a common skin tumor caused by abnormal hyperplasia of melanocytes, which is extremely malignant and accounts for a large part of skin tumor deaths. It occurs mostly on the skin or near the mucous membrane of ...
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Discovery of a protein that causes racial differences in prostate cancer
Discovery of a protein that causes racial differences in prostate cancer The prostate is a male-specific gonad. The prostate is as big as a chestnut, with its bottom facing up to the bladder and the sharp point pointing downwards to the urogenital ridge. It secretes prostatic fluid, which is ...
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The core of Alzheimer's disease is
The core of Alzheimer's disease is "lack of cleanness" in the brain cellsAs all we know, Alzheimer's disease (AD) is the common neurodegenerative disease, which is mainly characterized by failure of memory. And there has been no cure for AD so far. It is one of the global health concerns. The...
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How do neuroactive steroids suppress inflammatory signals in the immune system and brain?
How do neuroactive steroids suppress inflammatory signals in the immune system and brain?A study published in Nature Scientific Reports, in collaboration with UNC medical school and the University of Maryland, have shown how the neurosteroid allopregnanolone blocks the activation of pro-inflammatory proteins...
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How does sleep affect cardiovascular diseases?
How does sleep affect cardiovascular diseases?About one-third of one's lifespan is spent on sleep. When we sleep, our brain and body can get rest, recuperation and recovery. However, when our sleep is not enough or we suffer from sleep disorders, various diseases wi...
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The unexpected discovery about rheumatoid arthritis offers a novel therapy for joint inflammation
The unexpected discovery about rheumatoid arthritis offers a novel therapy for joint inflammationRheumatoid arthritis (RA) is an autoimmune disease in which the body's immune system mistakenly attacks the joints. The immune system normally protects its health by attacking foreign substances like bacteria and viruses...
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The proteins released by fat after exercise can improve glucose
The proteins released by fat after exercise can improve glucose As we all know, exercise make us stronger and healthier. But do you learn how exercise helps us healthy on a molecular level?  Researchers at Joslin Diabetes Center answered the question in a study that...
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The protein YTHDF1 enhances the anti-tumor response
The protein YTHDF1 enhances the anti-tumor responseOne reason that cancer cells can thrive is that they are able to escape from your immune system. Immunotherapy is a type of biological therapy that helps your immune system fight cancer. The immune system plays an import...
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The Superb Journal CA(IF=244.59) Once Again Released an Article -Speed Reading on American Cancer Data
The Superb Journal CA(IF=244.59) Once Again Released an Article -Speed Reading on American Cancer DataA CANCER JOURNAL FOR CLINICIANS (CA, IF=244.59), is a review, peer-reviewed academic journal sponsored by the American Cancer Society, covering cancer diagnosis, treatment, and prevention. Its impact factor has been a...
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Latest neuroscience SCI impact factor summary in 2018
Latest neuroscience SCI impact factor summary in 2018Impact Factor (IF) is a data item in the Journal Citation Reports (JCR) produced by Thomson Reuters. It refers to the total number of citations for papers published during the two preceding years in the year of the Journ...
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Essential reading|Ranking No.1 Impact Factor (IF244.59) Superb Periodical CA-2018 	 Latest Global Cancer Statistics
Essential reading|Ranking No.1 Impact Factor (IF244.59) Superb Periodical CA-2018 Latest Global Cancer StatisticsA CANCER JOURNAL FOR CLINICIANS(CA,IF=244.59)is a summarized Academic periodicals which is directed by American Cancer Society and performs peer review. The papers cover cancer diagnosis, treatment and prevention. ...
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The Ultimate Guide for A High Impact SCI Paper
The Ultimate Guide for A High Impact SCI PaperWe cannot put too much emphasis on the importance of publishing several high impact SCI papers successfully. If the journals are top ones like Nature, Science, Cell, Advanced Materials, it couldn't be better. However, it...
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Myocardial Infarction
Myocardial InfarctionCoronary heart disease (CHD) is a leading cause of death worldwide. Among the CHD, myocardial infarction (MI) is the most common form. Data from the United States indicates that about 25% of deaths in the United States a...
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Hemophilia and Coagulation Factors
Hemophilia and Coagulation FactorsWorld Hemophilia Day is celebrated annually on April 17 to raise awareness of hemophilia and other bleeding disorders. Hemophilia was once considered a royal disease in Europe [1]. It took many years for hemophilia to be...
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What Is the Cause of Amyotrophic Lateral Sclerosis?
What Is the Cause of Amyotrophic Lateral Sclerosis?"Don't be sad! The wheelchair is too tiny and I am just back to the universe". Stephen William Hawking said this on his deathbed. Hawking was diagnosed with amyotrophic Lateral Sclerosis in 1963 at 21 and was told that h...
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How Does Alzheimer's Disease Happen?
How Does Alzheimer's Disease Happen?Bill Gates, one of the world's richest men and founder of Microsoft, announced a $100 million research grant in the fall of 2017 to help with Alzheimer's research. September 21st is World Alzheimer's Disease Day...
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Histone demethylases: LSD and JmjC Families
Histone demethylases: LSD and JmjC FamiliesIn the eukaryotic nucleus, histone H2A and H2B interact closely to form dimers, H3 and H4 form tetramers, and two H2A, H2B dimers and one H3 and H4 tetramer form core histone octamers. DNA entangles with the core histone...
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What Is Hepatitis B Virus?
What Is Hepatitis B Virus?According to the statistics from the World Health Organization (WHO), approximately 300 million people worldwide suffer from hepatitis B. Hepatitis B-caused liver complications including cirrhosis, liver failure, and hep...
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An Overview of Leukemia
An Overview of LeukemiaSeptember 4 annually is the World Leukemia Awareness Day. According to foreign statistics of 2021, leukemia was one of the top 10 most common cancers among men and women in the United States, and its mortality rate was a...
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New finding of the role of TM4SF1
New finding of the role of TM4SF1Recently, the research group of Dr. Hua Gao and Dr. Filippo G. Giancotti discovered a new TM4SF1-involving signaling pathway of breast cancer metastasis. TM4SF1 couples with collagen receptor DDR1 (tyrosine-protein kinas...
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Fighting between Immune Cells and Cancer Cells
Fighting between Immune Cells and Cancer CellsThe body's immune cells and a variety of pathogens are in a war all the time. Probably the most daunting war is the fighting between immune cells and cancer cells. The formation, transfer and spreading of cancer cells ar...
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Mycobacterium tuberculosis
Mycobacterium tuberculosisAccording to data released by World Health Organization(WHO) in 2015, nearly 2 billion people in the world had been infected with mycobacterium tuberculosis (TB), 10% of them developed to be TB patients. About 9.6 millio...
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Nestin, the GPS in Human Body
Nestin, the GPS in Human BodyRecently, findings from Jiancheng Wang et al. revealed a pro-fibrotic function of nestin partially through promoting Rab11-dependent recycling of TβRI and provided a potential therapeutic target for the treatment of pul...
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Latest Studies on CTSB — A Multi-functional Protein
Latest Studies on CTSB — A Multi-functional ProteinCTSB (Cathepsin B) is a lysosomal cysteine protease that plays a role in protein degradation, tissue remodeling, and immune response. Recent research has highlighted its potential involvement in diseases such as Alzheime...
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Swimming???  Epstein-Barr Virus!!!
Swimming??? Epstein-Barr Virus!!!Recently it is reported that, in Harbin, more than 200 children have been infected EB virus when swimming. What is EB virus? How about these children now? The number is known to reach 225 according to those parents spont...
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Periostin, the Accomplice of Cancer and Asthma
Periostin, the Accomplice of Cancer and AsthmaHafez RA et al. found that Egyptian patients' serum periostin is significantly related to asthma and positively associated with IL13 level supporting its utility as a diagnostic biomarker in a 2022 study [1]. Accumulatin...
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 NEDD8, An Important Target in Adipogenesis and Cancer Treatment
NEDD8, An Important Target in Adipogenesis and Cancer TreatmentWith the continuous improvement of living standards, obesity has become one of the major problems troubling many people. Losing weight is a lifetime compulsory course for many people. A finding found by H. S. Park et al....
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The naughty gene – MCR-1
The naughty gene – MCR-1On our planet, there are a variety of plants and animals; there are beneficial microbes and harmful microbes; for humans, we are similar but different in individual. All things are diverse on this planet but share a simi...
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The Secret Life of Brain
The Secret Life of BrainEveryone seems familiar and also unfamiliar with his brain on the neck. Why A is so smart? Why B is a bit dull? Why C's reaction is so quick? How does your brain control your movements? Why the things we see are not the ...
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The Battle of Helicobacter Pylori
The Battle of Helicobacter PyloriHelicobacter pylori (HP) are micro-aerobic bacteria that survive in each area of the stomach and duodenum. HP were discovered by Barry Marshall and Robin Warren, and because of this, they won the 2005 Nobel Prize in Phys...
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The Monologue of Anti-cancer Drugs
The Monologue of Anti-cancer DrugsMy name is anti-cancer drugs. You all might be familiar with me. Most people don't want to have anything to do with me, all because of my opponent - the cancer cells, which are very horrible. However, as the old Chinese ...
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PHGDH - An Enzyme Related to Cancer Progression and Metastasis
PHGDH - An Enzyme Related to Cancer Progression and MetastasisThe high mortality of cancer is mainly due to the metastatic growth of cancer cells. Cancer metastasis initiates when cellular programs that enable dissemination and seeding in the distant organs are transiently acti...
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