Homeobox Transcription Factor- NANOGEmbryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo. Self-renewal and pluripotency are two distinctive characteristics of undifferentiated embryonic stem cells ...
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Oct4 -- The Gatekeeper of Pluripotency of Embryonic Stem CellsOct4 (octamer-binding transcription factor) is named for its ability to bind to the DNA of the Octamer motif. It is also known as Oct3, POU5F1, Oct-3/4, Otf3 or NF-A3. It is encoded by the POU5F1 gene and belongs to POU ...
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How Do You Get Exosomes?Exosomes were originally regarded as cellular metabolic waste. With the discovery of the antigen-presenting exosomes secreted by B lymphocytes involving anti-tumor responses in 1996 [1]and the exchange of genetic materia...
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How to Inquire and Utilize the Signal Pathway on KEGGThe signal pathway was first known as signal transmission. M. Rodbell proposed the concept of signal transduction in 1980 and has since been widely used. Signaling pathways refer to a series of enzymatic reactio...
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CD146, A Powerful Tumor MarkerCD146 is a membrane glycoprotein of a Ca2+-independent cell adhesion molecule that was first identified as a tumor marker because CD146 is highly expressed in melanoma but not in the corresponding normal control group. I...
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About Thyroid Tumor, This Information You Must Know!The thyroid gland is part of the endocrine system and is a hormone-producing gland that regulates the body's functions. Thyroid cancer (TC), which occurs in thyroid cells, is the most common endocrine - related cancer, a...
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Mesothelin: A Rising Star of Cancer ImmunotherapyMesothelin, also known as MSLN, is a cell surface glycoprotein encoded by the MSLN gene. The MSLN gene encodes a precursor protein that is enzymatically decomposed into two products: megakaryocyte-potentiating factor (MP...
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OMA1-A Potential Cancer Therapy TargetThe mitochondria are double-membrane-bound organelles found in most eukaryotic organisms and are the main energizing organelles of cells. The most prominent roles of mitochondria are to produce the energy currency of the...
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EphA3-A Regulator of Cell Adhesion and MigrationReceptor tyrosine kinase (RTKs) is a type I transmembrane glycoprotein that regulates cell growth, differentiation and migration. The Eph receptor family (erythropoietin-producing human hepatocellular carcinoma) is the l...
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A Comprehensive Overview of Ovarian CancerOvarian cancer, as a gynecological malignancy, exerts a significant impact on women's health. Its highly invasive nature and the challenge of early detection pose a threat to the quality and longevity of women's lives. ...
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