CCR8: a Specific Marker on Tregs Cells, the Next Promising Candidate for Antitumor Drugs!Accompanied by great success of PD-(L)1, immunotherapy become the next revolution in cancer treatment, but tumor tissue is commonly infiltrated with a large number of immunosuppressive cells, leading to the unsatisfactor...
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Approaches to Determinate Protein ConcentrationAccurate protein quantification is a critical step in most experiments and workflows where proteins are extracted, isolated, and analyzed by biochemical methods. Analyzing the interactions between biological molecules ...
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GFRAL: A Promising Metabolic Target for Improving Obesity and Anorexia/CachexiaGlobally, nearly 400 million people worldwide are obese and 19.3 million patients have been diagnosed of cancer, according to the statistics of World Health Organization. Each year, tens of thousands of people suffer fro...
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How to Properly Reconstitute Lyophilized Proteins?In scientific research, proteins need to be added to the culture system or injected into the animal body in the form of a liquid with a certain concentration. However, many protein products are provided lyophilized to ...
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GCGR: A Regulator of Energy Balance Holds a Potential in Treatment DiabetesWith the increase in the number of diagnosed diabetes, the diabetes drugs market is estimated to grow year by year. The new drugs design over diabetes treatment has soaked up more ink and excited more passion in recent y...
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Cross-reactivity of Antibody: Beneficial or Harmful?In 1796, English physician Edward Jenner made history by inoculating 8-year-old James Phipps with cowpox to protect him from deadly smallpox. This revolutionary first vaccine worked not by magic, but by a little-understo...
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TNFRSF9: A Potent Immune-Stimulator in CancerLast month, a study published on Nature Communications pointed that combining TNFRSF9 agonists with PD-L1 increases anti-tumor activity [1]. In recent years, TNFRSF9 has received much attention as a therapeutic target fo...
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The Overview of One Category of Important Cell Receptors: Receptor Tyrosine KinasesMulticellular organisms live in a complex milieu where signaling pathways play a key role in their survival. As important mediators of this signal cascade, tyrosine kinases exert critical effects in various biological ...
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An Overview of Cell Death: Necrosis and ApoptosisIn every human tissue, new cells are constantly being created while existing cells are constantly dying, so as to keep the total number of cells within the physiologically appropriate range. Cells in the human body hav...
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CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe?On July 4, 2021, an article published in the journal Frontiers in immunology (IF: 7.561) entitled "Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibit...
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