Surface Markers of Mesenchymal Stem CellsMesenchymal stem cells (MSCs) are a kind of adult stem cells that exist in various tissues (such as bone marrow, umbilical cord blood and umbilical cord tissue, placental tissue, adipose tissue, etc.) and have multidirec...
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Identify Treg Cells. You Can Do This.The immune system can accurately identify "self" and "non-self", make the body produce protective immune response and realize the monitoring of tumor. Treg cells are regulatory T cells, which are the basic ce...
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CD46, A Complement RegulatorCD46 was discovered in 1986 by Cole et al. using C3b affinity chromatography on peripheral blood lymphocytes [1]. CD46, also known as membrane co-protein (MCP), is a membrane protein. The nucleotide sequence of MCP is ho...
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63.9% Objective Response Rate! B7-H3 Targeted Therapy Transforms Small Cell Lung Cancer Treatment, Domestic Players Compete in Hundred-Billion-Yuan MarketB7-H3 (CD276), the "dual-faced immune sentinel," reached a watershed moment in 2025. In January 2025, Roche committed an upfront payment of $570 million to secure YL201, an ADC drug from Yilian Bio. That December, its Ph...
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PD-1-- An Important Immune CheckpointProgrammed death-1 (PD-1), also known as CD279, is another important negative costimulatory molecule following the discovery of CTLA4. Its ligand is PD-L1, also known as CD274, which, like PD-1, belongs to the CD28/B7 fa...
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A groundbreaking breakthrough! Domestic "sandwich" regimen boosts 2-year survival rate to 97% in B-ALL patients, as the CD22 target achieves another success.In recent years, with the breakthrough progress of CAR-T cell therapy in the treatment of B-cell malignancies, improving efficacy while overcoming challenges such as antigen escape and T-cell exhaustion has become a cent...
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Surface Markers of Natural Killer CellsNK cells, also known as natural killer cells, are a type of cytotoxic lymphocyte that is essential for the innate immune system. It was discovered and named in 1975 for its morphological specificity and was developed fro...
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Glial Fibrillary Acidic Protein - Astrocyte Specific MarkerGlial fibrillary acidic protein (GFAP) belongs to class III intermediate filaments (IFs) and is specifically expressed in the cytoplasm of central nervous system astrocytes (AS). It acts as an astrocyte-specific marker. ...
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Homeobox Transcription Factor- NANOGEmbryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo. Self-renewal and pluripotency are two distinctive characteristics of undifferentiated embryonic stem cells ...
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Oct4 -- The Gatekeeper of Pluripotency of Embryonic Stem CellsOct4 (octamer-binding transcription factor) is named for its ability to bind to the DNA of the Octamer motif. It is also known as Oct3, POU5F1, Oct-3/4, Otf3 or NF-A3. It is encoded by the POU5F1 gene and belongs to POU ...
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