Streptococcus pneumoniae, a Primary Cause of PneumoniaStreptococcus pneumoniae (S. pneumoniae) is a major cause of pneumonia, meningitis, sepsis and other serious illnesses worldwide. In November 2010, the WHO announced that between 700,000 and 1 million children under the ...
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The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in CancerRecently, CD38 causes fresh concerns in the field of anti-aging because two articles published in Nature Metabolis point that CD38 attributes to the NAD+ consumption [1-2]. NAD support is called by some as the "immortali...
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Exploring Biological Landscape of Cervical Cancer: A Comprehensive Overview for ResearchersCancer of the uterine cervix, also called cervical cancer, is among the most preventable human malignancies, yet it remains a leading cause of death among women worldwide [1] [2]. According to the data from World Health ...
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An Overview of CD226 and Its Promising Role in Cancer ImmunotherapyNowadays, ample evidence has shown the roles of immune checkpoints in cancer immunotherapy. Intriguingly, CD226, a well-known active receptor, it is increasingly being recognized and researched through the two articles p...
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Twice Halted in One Year! Is Akeso's CD73 Monoclonal Antibody in Jeopardy Again? Is PD-1's Golden Partner Still Worth It?In tumor immunotherapy, the limited response rate of PD-1/L1 inhibitors as monotherapies has made the search for a "golden partner" a central focus. CD73 was once regarded as one of the most promising immunometabolic tar...
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With the High Potential in Cancer Immunotherapy, CD40 Is Triggering AttentionLast month saw the newest FDA-approved orphan drug APX005M, an anti-CD40 agonist antibody. The company Apexigen announced that FDA has granted orphan drug designation status to APX005M for the treatment esophageal and ga...
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CD47, A New Target for Tumor ImmuneCD47, a classic "don't eat me" signal molecule, has long been recognized primarily for its role in regulating innate immune cells such as macrophages in tumor immunity. However, recent studies have revealed that CD47 is ...
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New Mechanism, NRP1 Enhances the Ability of SARS-CoV-2 InfectionAn outbreak of SARS-CoV-2 infections has caused a pandemic associated with COVID-19. As the research on the mechanism of the virus invasion is deepening, some potential mechanisms have been revealed. In early February, t...
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Hematopoietic Stem Cell Surface MarkerHematopoietic stem cells (HSC) are a type of adult stem cells with the characteristics of stem cells: self-renewal and differentiation potential. Hematopoietic stem cells are a kind of pluripotent stem cells der...
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Surface Markers of Mesenchymal Stem CellsMesenchymal stem cells (MSCs) are a kind of adult stem cells that exist in various tissues (such as bone marrow, umbilical cord blood and umbilical cord tissue, placental tissue, adipose tissue, etc.) and have multidirec...
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