How do Th1 and Th2 Cells Differentiate?Depending on the cytokines they synthesize and secrete, CD4+ helper T cells (Th) can be divided into two subgroups, type I helper T lymphocytes (Thl) and type II helper T cells (Th2) [1]. Both types of cells are differen...
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TCGA Database- A Good Partner of ResearchersThe Cancer Genome Atlas (TCGA) is a project collaboratively monitored by the National Cancer Institute (NCI) and the National Human Genome Research Institute in the United States (NHGRI) that has generated comprehensive,...
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Unraveling the Dynamic World of Histone Modifications: Implications in Gene Regulation and Disease PathogenesisHistone modification is a captivating and intricate field of epigenetics that delves into the dynamic changes in chromatin structure. This remarkable process profoundly impacts gene expression, transcriptional regulation...
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Histone modification and CancerHistone modification is an epigenetic mechanism by which more than 100 different post-translational modifications may occur at the amino-terminal ends of the histone tails in nucleosomes. Such modifications contain methy...
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How to Measure Histone Modification?Currently, in the research of histone modification, the most frequent and important issue is how to measure histone modification. And compared with the analysis of DNA methylomes, the implementation of epigenomic technol...
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How Does Histone Modification Affect Gene Expression?As mentioned in the article entitled "What a Powerful Artifact of DNA Compression - Histone", a histone modification is a series of post-translational modification (PTM) to histone proteins including methylation, phospho...
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Epigenetic Histone Modifications PathwayDisease and disorder research has been conducted in relation to the histone modifications pathway and malignant neoplasms, carcinogenesis, cell transformation, neoplastic, carcinoma. The histone modifications pathway has...
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What a Powerful Artifact of DNA Compression - HistoneDo you know that every cell in your body has almost six feet of DNA? The diameter of the largest human cell is just about the width of a hair. Is that thing amazing? Are you interested in how does all that DNA fit inside...
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Introduction of Hepatocellular Carcinoma Related Signaling PathwaysHepatocellular carcinoma (HCC) is the third most common death-related cancer in the world and the sixth most common tumor. The major risk factors for liver cancer include chronic viral hepatitis, alcoholism, carcinogens ...
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What A Paradoxical TNF Signaling Pathway-Based on Different ReceptorsTNF (Tumor Necrosis Factor), a type II transmembrane protein, is a 34kDa multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Connecting a wide variety of ...
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