CD70 (CD27L/TNFSF7): a TNF Receptor Member, a “Star” Target for Clinical Research in Systemic Lupus Erythematosus (SLE), Arthritis, and Tumors!
CD70 (CD27L/TNFSF7): a TNF Receptor Member, a “Star” Target for Clinical Research in Systemic Lupus Erythematosus (SLE), Arthritis, and Tumors!On January 27, 2024, a study published in the Journal of Autoimmunity explored the impact of CD70 methylation on systemic lupus erythematosus (SLE), revealing elevated levels in SLE patients' CD4+ T cells, potentially li...
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Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research!
Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research!In January 2024, a research paper titled "Remyelinating effect driven by transferrin-loaded extracellular vesicles" was included in the Scholar database [1]. The study explored using extracellular vesicles (EVs) as carri...
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Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research?
Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research?Myosin-regulated light chains (MLCs/MRLCs) constitute crucial elements within Myosin II, exerting significant influence on diverse life processes such as muscle contraction and cell division. Recent investigations have u...
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CCR9: A Member of the Chemokine Receptor Family, an Emerging Target for Numerous Tumor Researches!
CCR9: A Member of the Chemokine Receptor Family, an Emerging Target for Numerous Tumor Researches!Chemokine receptors, a type of G protein-coupled receptors, are increasingly recognized for their role in various biological processes. They impact normal growth, development, inflammatory responses, immunity, and diseas...
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Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer!
Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer!On January 3, 2024, a recent review titled "Research progress on the role of tumor-associated macrophages in tumor development and their use as molecular targets" sheds light on the pivotal role of tumor-associated macro...
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ACVRL1 (Alk1): a Member of the TGF-β Receptor Family, a Novel Target for Anti-Angiogenic Drug Research!
ACVRL1 (Alk1): a Member of the TGF-β Receptor Family, a Novel Target for Anti-Angiogenic Drug Research!Lately, the journal Nature Communications published a paper entitled "Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis" [1], emphasizing the importance of TG...
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Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research!
Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research!The journal Cancers recently published a paper titled "Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases" [1]. This paper highlights CD81 as a crucial targe...
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CTRAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family!
CTRAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family!CRTAM is a recently discovered member of the immunoglobulin superfamily (Ig-SF), a group of proteins crucial for immune system formation, response, and cell interactions. It functions as a cell-surface transmembrane prot...
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TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target?
TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target?In recent years, TM4SF1 has become a key target for many cancers. As part of the TM4SF protein family, TM4SF1 interacts within and outside cells, influencing vital processes like signaling and cell movement. Studies reve...
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Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!
Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!Pharmacokinetic (PK) assays play a pivotal role in pharmacology, offering essential insights into how drugs are absorbed, distributed, metabolized, and excreted in the body. They provide crucial understanding regarding d...
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