BTN3A1 (CD277) Target: γδ T Cell Immune Recognition Mechanism and Cancer Immunotherapy Research ProgressBTN3A1 (also known as CD277) is a key molecule for human Vγ9Vδ2 T cells to recognize phosphoantigens (pAg), and an important node connecting metabolic abnormality sensing, immune activation and therapeutic translation....
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CCN2 (CTGF) Target: Core Molecule of Fibrosis and Tumor Stroma Regulation | Disease Treatment Research ProgressCCN2 (also known as connective tissue growth factor, CTGF) is an important multifunctional matricellular protein that plays a key role in tissue development, homeostasis maintenance, fibrosis, cancer and various patholog...
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CD28: Molecular Mechanism and Therapeutic Progress of the Core Co-Stimulatory Receptor in T CellsT cell activation generally follows the classical "two-signal model": after the T cell receptor (TCR) recognizes an antigen, a second signal from co-stimulatory molecules is required to allow naive T cells to exit the qu...
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Overview of CCR4 Target: Core Roles in Physiological Functions and Pathological Regulation1. Overview of CCR4 targets: The core role of physiological function and pathological regulation C-C chemokine receptor 4 (CCR4) is an important member of the G protein-coupled receptor family, primarily...
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CDH1/E-cadherin: Research Progress on a Core Target from Adhesion Regulation to Tumor TherapyE-cadherin, encoded by the CDH1 gene, is a calcium-dependent cell adhesion molecule in epithelial cells, playing a central role in maintaining epithelial structural integrity, intercellular communication, and tissue home...
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BDNF/Brain-Derived Neurotrophic Factor: From Neuroplasticity Regulation to Core Target for Neuropsychiatric Disease TherapyBrain-derived neurotrophic factor (BDNF) is the most widely studied core member of the neurotrophin family, playing an irreplaceable role in central nervous system development, neuronal survival, and synaptic plasticity ...
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B2M/β2-Microglobulin: From Antigen Presentation Core to Key Target for Immunotherapy and Disease Predictionβ2-microglobulin (B2M), as the light chain subunit of MHC-I molecules, is a core component of the endogenous antigen presentation pathway and plays an irreplaceable role in CD8+ T cell recognition of viral and tumor ant...
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ASGR1: From Hepatic Clearance Receptor to Novel Target for Metabolic and Cardiovascular Disease TherapyASGR1 is the main functional subunit of the asialoglycoprotein receptor (ASGPR), which is almost specifically expressed in hepatocytes, giving it unique value in liver physiological regulation and targeted therapy. On on...
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Spanning Eight Major Cancers: Why Has Transmembrane Mucin MUC13 Become a New Focus in Precision Tumor Therapy?Transmembrane mucin MUC13（Mucin 13）It is an important component of the epithelial barrier and a signaling regulatory protein of great interest in tumor biology. Its structure includes a highly glycosylated extracellu...
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From "Physical Barrier" to "Signaling Hub": How Mucin MUC1 Drives Tumor Progression1. Structural Background and Physiological Functions of MUC1 The mucin family comprises several members, including transmembrane types (such as MUC1, MUC4, MUC16), secreted types, and soluble mucins. Amo...
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