FCGR3A: A Key Receptor for Immune Regulation1. The Role and Importance of FCGR3A in the Immune System Immunoglobulin G Fc segment receptor III A (FCGR3A, also known as CD16a) is a crucial activating receptor expressed on the surface of Natural Killer (...
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CRLF2 (TSLPR): A Key Target Linking Type 2 Inflammation to Hematologic MalignanciesThe thymic stromal lymphopoietin receptor (TSLPR, also known as CRLF2) is a key receptor subunit that mediates signaling by the epithelial-derived cytokine TSLP. Together with IL-7Rα, it forms a functional receptor comp...
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The Multifaceted World of ADAM9: Beyond Proteolytic Function1. An Overview of ADAM9: Structure and Biological Functions ADAM9, a transmembrane multidomain protein, exhibits both disintegrin and metalloproteinase activities. These functions allow it to modulate a ...
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PDGFRA: A Hub in Cellular Signaling and a Therapeutic TargetPlatelet-derived growth factor receptor alpha (PDGFRA) is a receptor tyrosine kinase that plays a critical role in embryonic development, cell proliferation, migration, and differentiation. Its aberrant activation is clo...
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BTLA: An Emerging Target in Immunotherapy – New Insights into Cancer and Autoimmune Diseases1. The Emerging Role of BTLA in Immune Regulation The advent of immune checkpoint inhibitors (ICIs) marks a major breakthrough in cancer treatment, significantly improving outcomes for patients with vari...
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Macrophage Migration Inhibitory Factor (MIF): A Pleiotropic Target Linking Inflammation and Cancer1. MIF Background: Structure, Expression Regulation, and Basic Biological Characteristics Macrophage migration inhibitory factor (MIF), initially named for its ability to inhibit macrophage migration, is...
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A Novel Target for Cancer Therapy: FAP – From Tumor Microenvironment Regulation to TheranosticsFibroblast activation protein (FAP), a key regulator in the tumor microenvironment, is emerging as a critical focus in cancer diagnostics and therapeutics. This article systematically elucidates the dual mechanisms of FA...
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GPR20: From "Orphan" to a Promising Novel Target for Overcoming Drug-Resistant GISTIn the field of cancer therapy, overcoming drug resistance remains a significant challenge for researchers. GPR20, a long-silent "orphan" GPCR, is emerging into the spotlight due to its unique profile in drug-resistant g...
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IL1RAP: Background, Research Mechanisms, Signaling Pathways, Related Diseases, and Latest Advances in Drug Development1. Background and Significance of IL1RAP Research Interleukin-1 receptor accessory protein (IL1RAP) is a key co-receptor in the IL-1 family signaling pathways, extensively involved in immune and inflamma...
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Western Blotting: Principles, Step-by-Step Workflow, and Troubleshooting GuideSince its development in 1979 by Towbin and colleagues, Western blotting (WB) has become an indispensable tool for detecting specific proteins in a complex sample [1]. Its enduring value lies in its ability to provide in...
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