SEZ6: A New Therapeutic Target for Neuroendocrine Tumors with Multiple ADCs in Clinical Development1. What is SEZ6？ Seizure-related 6 homolog (SEZ6) is a transmembrane protein initially discovered due to its association with epilepsy [1]. The gene is located on chromosome 17q21.33 and encodes a prot...
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Targeting the "Hidden Target" ROR1: A Breakthrough for Broad-Spectrum Cancer Therapy?1. What is ROR1？ Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transmembrane glycoprotein belonging to the ROR family. Its structure comprises extracellular immunoglobulin-like domains, cystei...
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Parathyroid Hormone (PTH): A Key Target for Regulating Calcium-Phosphate Metabolism and Skeletal Health1. What is PTH Parathyroid hormone (PTH) is the principal hormone secreted by the parathyroid glands and is essential for maintaining calcium-phosphate homeostasis. It critically regulates bone metabolis...
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LAG3: The Next Frontier in Tumor Immunotherapy1. What is LAG3？ Lymphocyte-activation gene 3 (LAG3, CD223) is an important immune checkpoint molecule that was first cloned in 1990. Its gene shares approximately 20% homology with the CD4 gene, encod...
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Interleukin-2 (IL2): The "Double-Edged Sword" of the Immune System1. What is Interleukin-2 (IL2)? Interleukin-2 (IL2) is a key immunoregulatory cytokine initially discovered for its ability to promote T cell proliferation. It plays a “double-edged sword” role in th...
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TSLP: A Key Target in Allergic and Inflammatory DiseasesThymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine primarily secreted by epithelial cells in response to environmental stimuli such as allergens, viruses, or pollutants. It plays a pivotal role in immune regul...
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LYPD3: An Emerging Star in Solid Tumor Therapy1. Overview of LYPD3 LYPD3 (Ly6/PLAUR Domain-Containing Protein 3), also known as C4.4A, is a glycosylphosphatidylinositol (GPI)-anchored cell membrane protein that plays a key role in tumor progression,...
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MICA: key regulatory molecule for tumor immune surveillance and its therapeutic target potential1. What is MICA MICA (Major Histocompatibility Complex Class I-Related Chain A) is an important stress-inducing cell surface glycoprotein belonging to the MHC class I related protein family. The gene is ...
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MICB: a key molecule that bridges cellular stress and immune responses1. What is MICB 1.1 Molecular structure and localization Major histocompatibility complex class I chain-related protein B (MICB) is located on the short arm of human chromosome 6...
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B7-H6: A Key Ligand of NK Cell Immune Checkpoints Reshaping the Landscape of Tumor ImmunotherapyB7-H6, also known as Natural Cytotoxicity Triggering Receptor 3 Ligand 1 (NCR3LG1), is a unique member of the B7 co-stimulatory/inhibitory molecule family. It is not constitutively expressed in normal tissues but is sign...
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