ACVR1C/ALK7: An Emerging Target in Metabolic Diseases and Cancer TherapyACVR1C/ALK7, as a key member of the TGF-β superfamily, has recently garnered significant attention due to its dual roles in metabolic regulation and tumor progression. It not only plays crucial roles in adipose tissue d...
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Beyond PD-1? The Potential and Breakthroughs of the Emerging Immune Checkpoint BTLAImmune checkpoint inhibitors, particularly those targeting the PD-1/PD-L1 pathway, have achieved groundbreaking progress in the field of cancer therapy. However, their limited response rates, the emergence of resistance,...
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2026 Trends in Macromolecular Drug Targets: GLP-1 Deepening, Cardiovascular Remodeling, Immune Combinations, and the "Post-PD-1" EraIn the field of macromolecular drug development, one change is becoming increasingly evident: It's not that molecules can't be made, but rather that selecting targets is becoming increasingly difficult. ...
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FCGR3A: A Key Receptor for Immune Regulation1. The Role and Importance of FCGR3A in the Immune System Immunoglobulin G Fc segment receptor III A (FCGR3A, also known as CD16a) is a crucial activating receptor expressed on the surface of Natural Killer (...
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CRLF2 (TSLPR): A Key Target Linking Type 2 Inflammation to Hematologic MalignanciesThe thymic stromal lymphopoietin receptor (TSLPR, also known as CRLF2) is a key receptor subunit that mediates signaling by the epithelial-derived cytokine TSLP. Together with IL-7Rα, it forms a functional receptor comp...
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The Multifaceted World of ADAM9: Beyond Proteolytic Function1. An Overview of ADAM9: Structure and Biological Functions ADAM9, a transmembrane multidomain protein, exhibits both disintegrin and metalloproteinase activities. These functions allow it to modulate a ...
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PDGFRA: A Hub in Cellular Signaling and a Therapeutic TargetPlatelet-derived growth factor receptor alpha (PDGFRA) is a receptor tyrosine kinase that plays a critical role in embryonic development, cell proliferation, migration, and differentiation. Its aberrant activation is clo...
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BTLA: An Emerging Target in Immunotherapy – New Insights into Cancer and Autoimmune Diseases1. The Emerging Role of BTLA in Immune Regulation The advent of immune checkpoint inhibitors (ICIs) marks a major breakthrough in cancer treatment, significantly improving outcomes for patients with vari...
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Macrophage Migration Inhibitory Factor (MIF): A Pleiotropic Target Linking Inflammation and Cancer1. MIF Background: Structure, Expression Regulation, and Basic Biological Characteristics Macrophage migration inhibitory factor (MIF), initially named for its ability to inhibit macrophage migration, is...
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A Novel Target for Cancer Therapy: FAP – From Tumor Microenvironment Regulation to TheranosticsFibroblast activation protein (FAP), a key regulator in the tumor microenvironment, is emerging as a critical focus in cancer diagnostics and therapeutics. This article systematically elucidates the dual mechanisms of FA...
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