Growth Hormone - Not Only Promotes Height IncreaseGrowth hormone 1, also known as somatotropin, or growth hormone (GH). It is a member of the growth hormone/prolactin family. It is a single peptide chain protein hormone secreted by pituitary gland. The role of this horm...
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TROP2, An Important Target for Cancer ResearchTROP2 belongs to the TACSTD family and is a cell surface glycoprotein encoded by the TACSTD2 gene. It is also known as tumor-associated calcium signal transducer 2 (TACSTD2), epidermal glycoprotein 1 (EGP-1), and gastroi...
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PD-1/PD-L1, What a Powerful Immune CheckpointImmune checkpoint therapy, mainly including anti-CTLA-4 therapy and anti-PD-1/PD-L1 therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses by blocking the inhibitory signals of the im...
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CD31- A Complex Function MoleculeAt the 2015 ASCO Annual Meeting, the team of Michael J. Birrer, MD, et al. proposed that CD31 is a potential biomarker for bevacizumab in ovarian cancer. Because the effect of bevacizumab on progression-free survival (PF...
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CD14, A Membrane Receptor for Bacterial LipopolysaccharidesCD14 (cluster of differentiation 14), formerly known as MY23 antigen, is a surface antigen and is a member of the cell surface glycoprotein family. The protein encoded by the CD14 gene is preferentially expressed in mono...
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CD44- A Powerful Bridge Between CellsLast year, one study from Kanazawa University showed new emerging role of osteopontin in HCV-related hepatocellular carcinoma. As the study mentioned, CD44 has been identified as the most common marker for cancer stem ce...
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Dual Role of TNFRSF14 in ImmunologyTumor necrosis factor receptor superfamily member 14 (TNFRSF14) is a member of the TNF receptor superfamily, also known as herpesvirus entry mediator (HVEM), CD270. In addition, it is also known as another TRAF-related r...
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Does TNF Superfamily Inhibit Cancer or Promote Its Development?The tumor necrosis factor superfamily (TNFSF) consists of 19 ligands and 29 receptors. TNF superfamily members induce a variety of biological effects, including cell growth, differentiation, and death by the interaction ...
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CD19-The Most Popular Target with CAR T-Cell TherapyAs the article named CAR-T Cell Therapy-An Useful Treatment to Cancer mentioned, CAR T-cell therapy is a type of treatment that involves collecting a patient's own immune T-cells and modifying them to produce a chimeric ...
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Tumor Necrosis Factor Receptor Superfamily and ApoptosisTumor necrosis factor receptor superfamily (TNFRSF) belongs to the transmembrane protein receptor, and its characteristic structure is its extracellular domain cysteine-rich domain (CRDs), which usually contains 6 cystei...
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