How to Inquire and Utilize the Signal Pathway on KEGGThe signal pathway was first known as signal transmission. M. Rodbell proposed the concept of signal transduction in 1980 and has since been widely used. Signaling pathways refer to a series of enzymatic reactio...
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CD146, A Powerful Tumor MarkerCD146 is a membrane glycoprotein of a Ca2+-independent cell adhesion molecule that was first identified as a tumor marker because CD146 is highly expressed in melanoma but not in the corresponding normal control group. I...
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About Thyroid Tumor, This Information You Must Know!The thyroid gland is part of the endocrine system and is a hormone-producing gland that regulates the body's functions. Thyroid cancer (TC), which occurs in thyroid cells, is the most common endocrine - related cancer, a...
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Mesothelin: A Rising Star of Cancer ImmunotherapyMesothelin, also known as MSLN, is a cell surface glycoprotein encoded by the MSLN gene. The MSLN gene encodes a precursor protein that is enzymatically decomposed into two products: megakaryocyte-potentiating factor (MP...
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OMA1-A Potential Cancer Therapy TargetThe mitochondria are double-membrane-bound organelles found in most eukaryotic organisms and are the main energizing organelles of cells. The most prominent roles of mitochondria are to produce the energy currency of the...
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EphA3-A Regulator of Cell Adhesion and MigrationReceptor tyrosine kinase (RTKs) is a type I transmembrane glycoprotein that regulates cell growth, differentiation and migration. The Eph receptor family (erythropoietin-producing human hepatocellular carcinoma) is the l...
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A Comprehensive Overview of Ovarian CancerOvarian cancer, as a gynecological malignancy, exerts a significant impact on women's health. Its highly invasive nature and the challenge of early detection pose a threat to the quality and longevity of women's lives. ...
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Growth Hormone - Not Only Promotes Height IncreaseGrowth hormone 1, also known as somatotropin, or growth hormone (GH). It is a member of the growth hormone/prolactin family. It is a single peptide chain protein hormone secreted by pituitary gland. The role of this horm...
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TROP2, An Important Target for Cancer ResearchTROP2 belongs to the TACSTD family and is a cell surface glycoprotein encoded by the TACSTD2 gene. It is also known as tumor-associated calcium signal transducer 2 (TACSTD2), epidermal glycoprotein 1 (EGP-1), and gastroi...
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PD-1/PD-L1, What a Powerful Immune CheckpointImmune checkpoint therapy, mainly including anti-CTLA-4 therapy and anti-PD-1/PD-L1 therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses by blocking the inhibitory signals of the im...
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