Activation-induced cytidine deaminase (AICDA) is an enzyme that mediates affinity maturation and promotes DNA demethylation in germinal center (GC) B cells, essential for the pathogenesis of DLBCL. The structural features of AICDA enable it to catalyze mutations in specific DNA sequences during the immune response of B cells. Overexpression of AICDA can lead to a more aggressive form of BCL2-driven mouse lymphoma. In addition to AICDA's role in modifying cytosine methylation during GC responses, it is also an important source of epigenetic heterogeneity in DLBCL. The epigenetic heterogeneity associated with AICDA is primarily related to the relative loss of cytosine methylation, which is consistent with AICDA's known mechanism of action in cytosine deamination. The epigenetic heterogeneity induced by AICDA increases plasticity, allowing cancer cells to exhibit greater population diversity and enhance the overall tumor's adaptability. AICDA plays a pivotal role in B-cell immune regulation. It promotes antibody diversity and specificity by inducing somatic hypermutation and class switch recombination of immunoglobulin genes. Therefore, AICDA recombinant protein holds significant importance in the study of disease mechanisms and the development of potential therapeutic approaches.
Recombinant Human Single-stranded DNA cytosine deaminase (AICDA)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following Aicda reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Aicda Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA001487GA01HU | AICDA Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA006133 | AICDA Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA001487LA01HU | AICDA Antibody |
Human, Mouse | ELISA, WB |
CSB-PA001487LB01HU | AICDA Antibody, HRP conjugated |
Human | ELISA |
Aicda Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP001487HU CSB-EP001487HU CSB-MP001487HU CSB-EP001487HU-B |
Recombinant Human Single-stranded DNA cytosine deaminase (AICDA) |
Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP001487HU | Recombinant Human Single-stranded DNA cytosine deaminase (AICDA) |
Baculovirus |