BCL2A1 Research Reagents

Bcl-2-related protein A1 is a protein in humans that is encoded by BCL2A1 gene. Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).

The following BCL2A1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BCL2A1 Antibodies

BCL2A1 Antibodies for Homo sapiens (Human)

BCL2A1 Proteins

BCL2A1 Proteins for Homo sapiens (Human)

BCL2A1 Proteins for Bos taurus (Bovine)

BCL2A1 ELISA Kit

BCL2A1 ELISA Kit for Homo sapiens (Human)

BCL2A1 Background

Bcl-2-related protein A1 also called Bcl-2 related gene expressed in fetal liver (Bfl-1), is a protein in humans that is encoded by the BCL2A1 gene on chromosome 15q24.3 [1]. BCL2A1 possesses four BH-domain: BH1-BH4. Crystal structures of BCL2A1 in complex with BH3-peptides revealed that it displays a similar hydrophobic groove as observed on all related anti-apoptotic Bcl-2 (B-cell lymphoma 2) proteins [2]. Although BCL2A1 does not exhibit a well-defined C-terminal transmembrane domain identified in other anti-apoptotic Bcl-2 proteins, its C-terminus is essential for the anti-apoptotic function and the subcellular localization of BCL2A1 [3]. BCL2A1 protein is particularly important in the hematopoietic system [10] and executes its anti-apoptotic function by sequestering pro-apoptotic BCL2 proteins [4]. The transcription of BCL2A1 is induced by NF-kappa B[5], retinoic X receptors (RXR) agonists [6], and WT-1 [7], but inhibited by the plasma cell transcription factor PRDI-BF1/Blimp-1 [8]. The identification of BCL2A1 as an NF-κB target gene shows that the formation of inflammasomes may also induce the expression of BCL2A1, thus promoting the survival of the pro-inflammatory cells during inflammation. The stability of BCL2A1 protein is regulated by proteasomal degradation [9]. BCL2A1 overexpression has been found in various hematological malignancies [10] as well as solid tumors [11] and seems to be notably associated with advanced or metastatic disease stages [12]. Besides a potential role in tumorigenesis, BCL2A1 overexpression is also involved in the resistance for chemotherapy.

[1] Choi SS, Park SH, et al. Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3 [J]. Mamm Genome 1997; 8: 781-782.
[2] Herman MD, Nyman T, et al. Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim & FEBS Lett 2008; 582: 3590-3594.
[3] Brien G, Debaud AL, et al. C-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1 [J]. J Biol Chem 2009; 284: 30257-30263.
[4] M Vogler. BCL2A1: the underdog in the BCL2 family [J]. Cell Death & Differentiation volume 19, 2012, pages67-74.
[5] Zong WX, Edelstein et al. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis [J]. Genes Dev 1999; 13: 382-387.
[6] Rasooly R, Schuster GU, et al. Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes [J]. J Immunol 2005; 175: 7916-7929.
[7] Simpson LA, Burwell EA, et al. The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy. [J]. Blood 2006; 107: 4695-4702.
[8] Shaffer AL, Lin KI, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. [J]. Immunity 2002; 17: 51-62.
[9] Herold MJ, Zeitz J, et al. The stability and anti-apoptotic function of A1 are controlled by its C terminus [J]. J Biol Chem 2006; 281: 13663-13671.
[10] Choi SS, Park IC, et al. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow [J]. Oncogene 1995; 11: 1693-1698.
[11] Park IC, Lee SH, et al. Expression of a novel Bcl-2 related gene, Bfl-1, in various human cancers and cancer cell lines [J]. Anticancer Res 1997; 17: 4619-4622.
[12] Yoon HS, Hong SH, et al. Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors [J]. J Korean Med Sci 2003; 18: 225-230.

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