NOD2 Research Reagents

Nucleotide-binding oligomerization domain-containing protein 2 is a protein in humans that is encoded by NOD2 gene. Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages.

The following NOD2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NOD2 Antibodies

NOD2 Antibodies for Homo sapiens (Human)

NOD2 Antibodies for Bos taurus (Bovine)

NOD2 Proteins

NOD2 Proteins for Hylobates lar (Common gibbon) (White-handed gibbon)

NOD2 Proteins for Pan troglodytes (Chimpanzee)

NOD2 Proteins for Bos taurus (Bovine)

NOD2 Proteins for Mus musculus (Mouse)

NOD2 Proteins for Homo sapiens (Human)

NOD2 Proteins for BO-Bos taurus (Bovine)


NOD2 ELISA Kit for Homo sapiens (Human)

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