NAD-dependent protein deacetylase sirtuin-6 is a protein in humans that is encoded by SIRT6 gene. NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability.

SIRT6 Antibodies

SIRT6 Antibodies for Homo sapiens (Human)

SIRT6 Antibodies for Drosophila melanogaster (Fruit fly)

SIRT6 Proteins

SIRT6 Proteins for Mus musculus (Mouse)

SIRT6 Proteins for Homo sapiens (Human)


SIRT6 ELISA Kit for Homo sapiens (Human)


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1