NAD-dependent protein deacetylase sirtuin-6 is a protein in humans that is encoded by SIRT6 gene. NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability.
The following SIRT6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SIRT6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021344GA01HU | SIRT6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA854057ESR2HU | SIRT6 Antibody | Human | ELISA |
CSB-PA959450 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
CSB-PA113703 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
SIRT6 Antibodies for Drosophila melanogaster (Fruit fly)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA263741XA01DLU | Sirt6 Antibody | Drosophila melanogaster (Fruit fly) | ELISA, WB (ensure identification of antigen) |
SIRT6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP021344MO CSB-EP021344MO CSB-BP021344MO CSB-MP021344MO CSB-EP021344MO-B |
Recombinant Mouse NAD-dependent protein deacetylase sirtuin-6 (Sirt6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SIRT6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP854057HU CSB-BP854057HU CSB-MP854057HU CSB-EP854057HU-B |
Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP854057HU | Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | E.coli |
SIRT6 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E17018h | Human NAD-dependent deacetylase sirtuin-6 (SIRT6/SIR2L6) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.78 pg/mL |