NCAN Antibody

1. NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. PMID: 27887608
2. This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. PMID: 26758378
3. NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation PMID: 25801500
4. current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects. PMID: 25220293
5. The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%). PMID: 24946282
6. NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia. PMID: 23795679
7. Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD). PMID: 24978903
8. NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis. PMID: 23594525
9. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia. PMID: 23198940
10. In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity. PMID: 22952076
11. The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia. PMID: 22497794
12. High neurocan is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
13. Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups. PMID: 22208664
14. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder. PMID: 21353194

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HGNC: 2465

OMIM: 600826

KEGG: hsa:1463

STRING: 9606.ENSP00000252575

UniGene: Hs.169047