Mmp2 Antibody

1. there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family PMID: 28300207
2. inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration PMID: 29563183
3. Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes. PMID: 28192468
4. We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger. PMID: 26473732
5. Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells. PMID: 25695427
6. As a Wnt signaling antagonist, MMP2 cleaves the glypican, reducing the ability of Dlp to interact with the Wnt ligand and promote its distribution. PMID: 25267296
7. Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila PMID: 21978772
8. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. PMID: 21471368
9. Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes PMID: 20412776
10. Mmp2 expression in the developing air sac is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling. PMID: 20152186
11. complete base sequence given for a 758 residue polypeptide PMID: 11967260
12. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. PMID: 12530966
13. MMP activity is essential for embryonic motor axon fasciculation PMID: 18045838
14. findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix PMID: 19751719

Show More

Hide All

KEGG: dme:Dmel_CG1794

STRING: 7227.FBpp0087585

UniGene: Dm.11246