Mmp2 Antibody

Code CSB-PA238276XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Mmp2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Mmp2 antibody; CG1794Matrix metalloproteinase-2 antibody; Dm2-MMP antibody; EC 3.4.24.- antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Mmp2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Has metalloproteinase activity. Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue. Required for growth of the dorsal air sac primordium and development of the dorsal air sacs. Promotes embryonic motor axon fasciculation. Cleaves and activates frac to promote motor axon bundling during outgrowth. Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow. Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation. Plays a role in wound healing. Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions. Required for posterior follicle cell degradation and ovulation.
Gene References into Functions
  1. there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family PMID: 28300207
  2. inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration PMID: 29563183
  3. Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes. PMID: 28192468
  4. We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger. PMID: 26473732
  5. Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells. PMID: 25695427
  6. As a Wnt signaling antagonist, MMP2 cleaves the glypican, reducing the ability of Dlp to interact with the Wnt ligand and promote its distribution. PMID: 25267296
  7. Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila PMID: 21978772
  8. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. PMID: 21471368
  9. Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes PMID: 20412776
  10. Mmp2 expression in the developing air sac is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling. PMID: 20152186
  11. complete base sequence given for a 758 residue polypeptide PMID: 11967260
  12. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. PMID: 12530966
  13. MMP activity is essential for embryonic motor axon fasciculation PMID: 18045838
  14. findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix PMID: 19751719

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Peptidase M10A family
Tissue Specificity
Widely expressed during embryogenesis including in the mesoderm, developing gut, central and peripheral nervous systems and imaginal disks. In the embryonic nervous system, expressed in neurons and glia. In third instar larvae, strongly expressed in the m
Database Links

KEGG: dme:Dmel_CG1794

STRING: 7227.FBpp0087585

UniGene: Dm.11246

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