fru Antibody

1. We find four times more male-biased than female-biased genes in TRAP mRNAs from fru P1-expressing neurons. This suggests a potential mechanism to generate dimorphism in behavior PMID: 27247289
2. Enhanced male-male courtship, a fru mutant "hallmark," disappears when fru-mutant males are raised in isolation; neural fru expression is induced by neural activities in the adult invites the supposition that Fru as a chromatin regulator mediates experience-dependent epigenetic modification, which underlies the neural and behavioral plasticity. [Review] PMID: 27880074
3. results highlight two feed-forward regulatory mechanisms with both developmentally hardwired and olfactory receptor activity-dependent components that establish and maintain fru expression in ORNs PMID: 27093619
4. This study found that a 1.5-2-kb genomic fragment located 4-6-kb upstream of the P1 promoter in D. subobscura but not that of D. melanogaster permits MOL formation in females. PMID: 25518733
5. Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation. PMID: 24642956
6. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development. PMID: 25483248
7. A small subset of fruitless subesophageal neurons modulate early courtship in Drosophila. PMID: 24740138
8. These data map specific aspects of Drosphila courtship behavior to the level of single fru isoforms and fru(+) cell types PMID: 24440391
9. These findings suggest that Fru isoform diversity facilitates both redundancy and specificity in gene expression PMID: 24440396
10. This study elucidates the different regulatory and DNA binding activities of three Fru male specific isoforms on a genome-wide scale and identifies genes regulated by these isoforms. PMID: 24074028
11. Study shows that such fru(M) null males acquire the potential for courtship when grouped with other flies; they apparently learn to court flies with which they were grouped, irrespective of sex or species and retain this behavior for at least a week. PMID: 24439379
12. The male courtship circuitry is the fruitless (fru) gene play a key role of courtship behaviour in Drosophila. PMID: 24052176
13. Fru determines the level of masculinization of neurons by orchestrating the transcription of a set of downstream genes, which remain to be identified. PMID: 19012071
14. This chapter reviews the role of fruitless and the neurons that express it in the regulation of courtship behavior. PMID: 21906537
15. Male courtship is initiated by direct activation of fru-expressing neurons in the absence of a courtship target. PMID: 21315260
16. Transgenic expression of an RNAi construct directed against male-specific fruitless (fru(M)) transcripts resulted in normal wing extension, but highly defective courtship song, with 58% of males failing to generate detectable courtship song. PMID: 20919857
17. one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS PMID: 12524343
18. mechanisms of enhancer-dependent regulation of alternative 5'-splice sites PMID: 12646561
19. Phenotypic analyses and rescue experiments provide evidence that one of the sex-nonspecific functions of the fru gene is the maintenance of neuronal identity rather than establishment of a neuron's initial fate. PMID: 12672012
20. Gal4 expression in neurites innervating male reproductive structures are hypothesized to be targets of fruitless function. PMID: 15211467
21. spliced differently in males and females, determines male courtship behavior PMID: 15935764
22. FruM proteins specify the neural substrates of male courtship PMID: 15959468
23. Fru expression can produce a male-specific neural circuit, probably used during heterosexual courtship, by preventing cell death in identifiable neurons PMID: 16281036
24. Distinctive reproductive behaviors of males and females are mediated by a common fru neural circuit. PMID: 16713940
25. Complex behaviors can be controlled by the single fruitless locus through multiple isoforms regulating both developmental and physiological pathways in different neuronal substrates. PMID: 16753560
26. Sex-specific splicing of the fruitless gene plays a critical role in determining who and how a fly fights, and whether a dominance relationship forms. PMID: 17115036
27. dsx required for specifying a sexually dimorphic population of fru-expressing neurons in the mesothoracic ganglion PMID: 17716899
28. fruitless and doublesex genes are both required in thoracic neurons to generate normal male lovesongs. PMID: 17925211
29. Fru expression is absent when flies fight like females and present when flies fight like males, thereby beginning a separation between courtship and aggression among these neurons. PMID: 18042702

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KEGG: dme:Dmel_CG14307

STRING: 7227.FBpp0290499

UniGene: Dm.4626