Human Macrophage Inflammatory Protein-3β,MIP-3β ELISA kit

Code CSB-E04670h
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. Q99731
Lead Time 3-5 working days
Protein Biological Process 2 chemokine
Abbreviation CCL19
Protein Biological Process 1 Immunity
Target Name chemokine (C-C motif) ligand 19
Alias RP11-195F19.11, CKb11, ELC, MGC34433, MIP-3b, MIP3B, SCYA19, CC chemokine ligand 19|CK beta-11|EBI1-ligand chemokine|beta chemokine exodus-3|exodus-3|macrophage inflammatory protein 3-beta|small ind
Species Homo sapiens (Human)
Protein Biological Process 3 Chemotaxis
Sample Types serum, plasma, tissue homogenates
Detection Range 39 pg/ml-2500 pg/ml
Sensitivity 9.75 pg/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target Details This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
HGNC 10617
RGD 1310336
MGI 1346316
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Function May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
Database Links

HGNC: 10617

OMIM: 602227

KEGG: hsa:6363

STRING: 9606.ENSP00000308815

UniGene: Hs.50002

Pathway Chemokine signaling pathway
NF-kappa B signaling pathway

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