Recombinant Human Platelet-derived Growth Factor-BB(PDGFB),partial (Active) (GMP)

In StockGMP
Code CSB-AP005941HU
Product Type Growth Factor
Size $5107Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P01127
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Alias PDGF subunit B PDGF-2 Platelet-derived growth factor B chain Platelet-derived growth factor beta polypeptide Proto-oncogene c-Sis INN: Becaplermin
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of > 3.3 × 105 IU/mg.
Purity > 98 % by SDS-PAGE and HPLC analyses.
Endotoxin Less than 0.01 EU/μg of rHuPDGF-BB GMP as determined by LAL method.
Sequence M+SLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPV
Research Area Cancer
Source E.Coli
Gene Names PDGFB
Expression Region 82-190aa
Tag Info Tag-Free
Mol. Weight 12.4kDa
Protein Description Partial
PubMed ID 6740330; 4033772; 2991848; 3472769; 3517869; 15461802; 10591208; 15489334; 7659502; 8988177; 6327048; 3456904; 6306471; 6844921; 6329745; 1661670; 1317862; 11331882; 12660034; 26599395; 18483217; 1396586; 20534510; 23913003
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Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin
Involvement in disease Basal ganglia calcification, idiopathic, 5 (IBGC5)
Subcellular Location Secreted
Protein Families PDGF/VEGF growth factor family
Tissue Specificity Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Database Links

HGNC: 8800

OMIM: 190040

KEGG: hsa:5155

STRING: 9606.ENSP00000330382

UniGene: Hs.1976

Pathway Jak-STAT signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Ras signaling pathway
Phospholipase D signaling pathway
Rap1 signaling pathway

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